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NTRA vs. TEM: Natera vs. Tempus AI Stock Comparison

How do Natera (NTRA) and Tempus AI (TEM) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Natera (NTRA) and Tempus AI (TEM) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but NTRA is classified in Biotechnology while TEM is classified in Life Sciences Tools & Services.

Natera (NTRA) has been public since July 1, 2015, giving it a longer listed trading history, while Tempus AI (TEM) listed on June 14, 2024 and still has a shorter public-market record.

Company profile comparison for Natera (NTRA) and Tempus AI (TEM)
Profile ItemNTRATEM
NameNatera, Inc.Tempus AI Inc Class A Common Stock
Country/RegionUnited StatesUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnologyLife Sciences Tools & Services
GICS Sub-IndustryBiotechnologyLife Sciences Tools & Services
Market Capitalization45.05 billion USD13.87 billion USD
CurrencyUSDUSD
ExchangeNasdaqNasdaq
Listing DateJuly 1, 2015June 14, 2024
Security TypeCommon StockCommon Stock

Price Performance

Cumulative Growth

NTRA
TEM
GSPC
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Natera (NTRA) vs. Tempus AI (TEM), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Natera (NTRA) and Tempus AI (TEM). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Natera (NTRA) and Tempus AI (TEM). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Natera (NTRA) and Tempus AI (TEM)
MetricNTRATEM
Total Return (1Y)61.03%16.25%
Total Return (3Y, Annualized)92.02%--
Total Return (5Y, Annualized)23.20%--

Risk Profile

Drawdown History

NTRA
TEM
GSPC
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Natera (NTRA) vs. Tempus AI (TEM), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Natera (NTRA) and Tempus AI (TEM). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for Natera (NTRA) and Tempus AI (TEM)
MetricNTRATEM
Volatility (1Y, Annualized)52.30%76.08%
Beta (5Y)1.583.34
Max Drawdown (5Y)-75.72%-59.76%
Avg. Volume (3M)1.68M7.20M

Risk-Adjusted Performance

Risk-Return Positioning

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NTRA and TEM are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Natera (NTRA) and Tempus AI (TEM)
MetricNTRATEM
Sharpe Ratio (1Y)1.090.16
Sortino Ratio (1Y)1.630.26

Profitability

ROE (TTM)

Both Natera (NTRA) at -10.55% and Tempus AI (TEM) at -37.55% report negative ROE values. Negative ROE can reflect losses or negative shareholders’ equity, so both readings need extra context.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

-10.55%

Max
109.18%
Q3
6.23%
NTRA
-10.55%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-37.55%

Max
109.18%
Q3
6.23%
Median
-26.66%
TEM
-37.55%
Q1
-64.05%
Min
-167.77%
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Natera (NTRA) vs. Tempus AI (TEM): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Both Natera (NTRA) at -5.66% and Tempus AI (TEM) at -12.54% report negative net margin values, usually indicating net losses over the period.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

-5.66%

Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
NTRA
-5.66%
Min
-17.05%

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-12.54%

Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
TEM
-12.54%
Min
-17.05%
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Natera (NTRA) vs. Tempus AI (TEM): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Natera (NTRA) at -7.64% and Tempus AI (TEM) at -13.82% report negative operating margin values, usually indicating operating losses over the period.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

-7.64%

Max
83.12%
Q3
14.77%
Median
0.00%
NTRA
-7.64%
Q1
-78.82%
Min
-207.40%

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-13.82%

Max
83.12%
Q3
14.77%
Median
0.00%
TEM
-13.82%
Q1
-78.82%
Min
-207.40%
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Natera (NTRA) vs. Tempus AI (TEM): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Natera (NTRA) and Tempus AI (TEM)
MetricNTRATEM
ROE (TTM)-10.55%-37.55%
ROA (TTM)-6.79%-7.36%
Net Margin (TTM)-5.66%-12.54%
Operating Margin (TTM)-7.64%-13.82%
Gross Margin (TTM)65.14%64.46%

Growth

Revenue Growth

Tempus AI (TEM) at 83.41% sits in the top revenue growth quartile, while Natera (NTRA) at 35.90% is closer to the peer norm — faster top-line expansion for TEM.

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Natera (NTRA) vs. Tempus AI (TEM): A comparison of their Revenue Growth across different time periods.

EPS Growth

Neither Natera (NTRA) nor Tempus AI (TEM) reports a EPS growth value for this period, so a direct comparison isn't possible.

Growth Metrics

Growth metrics for Natera (NTRA) and Tempus AI (TEM)
MetricNTRATEM
Revenue Growth (YoY)35.90%83.41%
Revenue Growth (3Y CAGR)41.14%58.29%
EPS Growth (YoY)----
EPS Growth (3Y CAGR)----

Financial Strength

Current Ratio (MRQ)

Both Natera (NTRA) at 2.81 and Tempus AI (TEM) at 2.61 carry current ratio within their industries’ typical mid-ranges, suggesting balanced short-term liquidity relative to peers.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.81

Max
25.13
Q3
12.13
Median
5.52
NTRA
2.81
Q1
2.47
Min
0.10

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.61

Max
25.13
Q3
12.13
Median
5.52
TEM
2.61
Q1
2.47
Min
0.10
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Natera (NTRA) vs. Tempus AI (TEM): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Natera (NTRA) at 0.13 is near its industry mid-range for debt-to-equity ratio, while Tempus AI (TEM) at 2.86 sits above its benchmark range, pointing to a heavier debt load relative to equity.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.13

Max
1.42
Q3
0.65
Median
0.15
NTRA
0.13
Q1
0.02
Min
0.00

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.86

TEM
2.86
Max
1.42
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
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Natera (NTRA) vs. Tempus AI (TEM): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Natera (NTRA) and Tempus AI (TEM)
MetricNTRATEM
Current Ratio (MRQ)2.812.61
Debt / Equity (MRQ)0.132.86
Net Debt / EBITDA----

Dividends

Dividend Yield (TTM)

Neither Natera (NTRA) nor Tempus AI (TEM) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

NTRA
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

TEM
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Natera (NTRA) vs. Tempus AI (TEM): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Neither Natera (NTRA) nor Tempus AI (TEM) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

NTRA
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

TEM
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Natera (NTRA) vs. Tempus AI (TEM): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Natera (NTRA) and Tempus AI (TEM)
MetricNTRATEM
Dividend Yield (TTM)0.00%0.00%
Dividend Payout Ratio (TTM)0.00%0.00%

Valuation

P/E Ratio (TTM)

Neither Natera (NTRA) nor Tempus AI (TEM) reports a P/E ratio value for this period, so a direct comparison isn’t possible.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

--

Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07
NTRA
--

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

--

Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07
TEM
--
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Natera (NTRA) vs. Tempus AI (TEM): Neither stock reports P/E ratio, so the chart shows available benchmark boxes without value markers.

P/S Ratio (TTM)

On P/S ratio, both Natera (NTRA) at 15.49 and Tempus AI (TEM) at 9.19 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

15.49

Max
58.18
Q3
25.77
NTRA
15.49
Median
7.30
Q1
3.01
Min
0.01

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

9.19

Max
58.18
Q3
25.77
TEM
9.19
Median
7.30
Q1
3.01
Min
0.01
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Natera (NTRA) vs. Tempus AI (TEM): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Measured against book value, both Natera (NTRA) at 23.99 and Tempus AI (TEM) at 27.66 look expensive — each P/B ratio sits above its industry’s benchmark range.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

23.99

NTRA
23.99
Max
13.53
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

27.66

TEM
27.66
Max
13.53
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59
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Natera (NTRA) vs. Tempus AI (TEM): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Natera (NTRA) and Tempus AI (TEM)
MetricNTRATEM
P/E Ratio (TTM)----
P/S Ratio (TTM)15.499.19
P/B Ratio (MRQ)23.9927.66
Free Cash Flow Yield (TTM)0.19%0.30%