GH vs. SYK: Guardant Health vs. Stryker Stock Comparison

November 11, 2026

How do Guardant Health (GH) and Stryker (SYK) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Guardant Health (GH) and Stryker (SYK) both fall under the Health Care Equipment & Services industry group, but GH is classified in Health Care Providers & Services while SYK is classified in Health Care Equipment & Supplies.

Company profile comparison for Guardant Health (GH) and Stryker (SYK)
Profile Item	GH	SYK
Name	Guardant Health, Inc.	Stryker Corp.
Country/Region	United States	United States
GICS Sector	Health Care	Health Care
GICS Industry Group	Health Care Equipment & Services	Health Care Equipment & Services
GICS Industry	Health Care Providers & Services	Health Care Equipment & Supplies
GICS Sub-Industry	Health Care Services	Health Care Equipment
Market Capitalization	20.41 billion USD	124.06 billion USD
Currency	USD	USD
Exchange	Nasdaq	NYSE
Listing Date	October 4, 2018	March 17, 1980
Security Type	Common Stock	Common Stock

Price Performance

Cumulative Growth

SYK

GSPC

Guardant Health (GH) vs. Stryker (SYK), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Guardant Health (GH) and Stryker (SYK). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Guardant Health (GH) and Stryker (SYK). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Guardant Health (GH) and Stryker (SYK)
Metric	GH	SYK
Total Return (1Y)	66.53%	-6.99%
Total Return (3Y, Annualized)	92.76%	7.60%
Total Return (5Y, Annualized)	8.36%	4.64%

Risk Profile

Drawdown History

SYK

GSPC

Guardant Health (GH) vs. Stryker (SYK), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Guardant Health (GH) and Stryker (SYK). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for Guardant Health (GH) and Stryker (SYK)
Metric	GH	SYK
Volatility (1Y, Annualized)	53.23%	32.80%
Beta (5Y)	1.69	0.72
Max Drawdown (5Y)	-85.09%	-32.47%
Avg. Volume (3M)	1.97M	2.81M

Risk-Adjusted Performance

Risk-Return Positioning

GH and SYK are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Guardant Health (GH) and Stryker (SYK)
Metric	GH	SYK
Sharpe Ratio (1Y)	1.17	-0.34
Sortino Ratio (1Y)	1.84	-0.49

Profitability

ROE (TTM)

Capital efficiency shows on one side only: Stryker (SYK) earns 16.02% on shareholders’ equity, ranked against its industry; Guardant Health (GH) has no ROE this period.

GH

Health Care Equipment & Services industry group

Max: 47.61%
Q3: 14.36%
Median: 5.45%
Q1: -10.67%
Min: -47.01%
GH: --

SYK

Health Care Equipment & Services industry group

16.02%

Max: 47.61%
SYK: 16.02%
Q3: 14.36%
Median: 5.45%
Q1: -10.67%
Min: -47.01%

Guardant Health (GH) vs. Stryker (SYK): GH does not report ROE, so it has no value marker; SYK is benchmarked against the Health Care Equipment & Services industry group.

Net Margin (TTM)

Guardant Health (GH) reports a negative net margin of -37.93%, usually indicating a net loss over the period. Meanwhile Stryker (SYK) reports 13.78%, ranking against industry peers normally.

GH

Health Care Equipment & Services industry group

-37.93%

Max: 29.35%
Q3: 9.33%
Median: 2.18%
Q1: -6.29%
Min: -28.46%
GH: -37.93%

SYK

Health Care Equipment & Services industry group

13.78%

Max: 29.35%
SYK: 13.78%
Q3: 9.33%
Median: 2.18%
Q1: -6.29%
Min: -28.46%

Guardant Health (GH) vs. Stryker (SYK): A comparison of their net margin against the Health Care Equipment & Services industry group benchmark.

Operating Margin (TTM)

Guardant Health (GH) reports a negative operating margin of -37.06%, usually indicating that operating costs exceeded revenue at the operating-income line. Meanwhile Stryker (SYK) reports 22.96%, ranking against industry peers normally.

GH

Health Care Equipment & Services industry group

-37.06%

Max: 35.43%
Q3: 14.14%
Median: 6.81%
Q1: -0.28%
Min: -16.29%
GH: -37.06%

SYK

Health Care Equipment & Services industry group

22.96%

Max: 35.43%
SYK: 22.96%
Q3: 14.14%
Median: 6.81%
Q1: -0.28%
Min: -16.29%

Guardant Health (GH) vs. Stryker (SYK): A comparison of their operating margin against the Health Care Equipment & Services industry group benchmark.

Profitability Metrics

Profitability metrics for Guardant Health (GH) and Stryker (SYK)
Metric	GH	SYK
ROE (TTM)	--	16.02%
ROA (TTM)	-19.92%	8.36%
Net Margin (TTM)	-37.93%	13.78%
Operating Margin (TTM)	-37.06%	22.96%
Gross Margin (TTM)	65.19%	65.70%

Growth

Revenue Growth

Guardant Health (GH) at 32.88% sits in the top revenue growth quartile, while Stryker (SYK) at 11.16% is closer to the peer norm — faster top-line expansion for GH.

Guardant Health (GH) vs. Stryker (SYK): A comparison of their Revenue Growth across different time periods.

EPS Growth

Only one side can be read here: Stryker (SYK) reports EPS growth of 8.25%, ranked against its industry; Guardant Health (GH) has no EPS growth figure this period.

Guardant Health (GH) vs. Stryker (SYK): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Guardant Health (GH) and Stryker (SYK)
Metric	GH	SYK
Revenue Growth (YoY)	32.88%	11.16%
Revenue Growth (3Y CAGR)	29.75%	10.83%
EPS Growth (YoY)	--	8.25%
EPS Growth (3Y CAGR)	--	10.83%

Financial Strength

Current Ratio (MRQ)

Both Guardant Health (GH) at 3.60 and Stryker (SYK) at 2.18 carry current ratio within their industries’ typical mid-ranges, suggesting balanced short-term liquidity relative to peers.

GH

Health Care Equipment & Services industry group

3.60

Max: 7.59
Q3: 4.00
GH: 3.60
Median: 1.98
Q1: 1.37
Min: 0.30

SYK

Health Care Equipment & Services industry group

2.18

Max: 7.59
Q3: 4.00
SYK: 2.18
Median: 1.98
Q1: 1.37
Min: 0.30

Guardant Health (GH) vs. Stryker (SYK): A comparison of their current ratio against the Health Care Equipment & Services industry group benchmark.

Debt / Equity (MRQ)

Only one side’s leverage can be read here: Stryker (SYK) carries debt-to-equity ratio of 0.66 against its industry range, while Guardant Health (GH) reports no figure this period.

GH

Health Care Equipment & Services industry group

Max: 1.88
Q3: 0.91
Median: 0.58
Q1: 0.16
Min: 0.00
GH: --

SYK

Health Care Equipment & Services industry group

0.66

Max: 1.88
Q3: 0.91
SYK: 0.66
Median: 0.58
Q1: 0.16
Min: 0.00

Guardant Health (GH) vs. Stryker (SYK): GH does not report debt-to-equity ratio, so it has no value marker; SYK is benchmarked against the Health Care Equipment & Services industry group.

Financial Strength Metrics

Financial strength metrics for Guardant Health (GH) and Stryker (SYK)
Metric	GH	SYK
Current Ratio (MRQ)	3.60	2.18
Debt / Equity (MRQ)	--	0.66
Net Debt / EBITDA	--	1.62

Dividends

Dividend Yield (TTM)

Guardant Health (GH) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Stryker (SYK) reports a yield of 1.05%, ranking against industry peers normally.

GH

Health Care Equipment & Services industry group

0.00%

GH: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

SYK

Health Care Equipment & Services industry group

1.05%

SYK: 1.05%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

Guardant Health (GH) vs. Stryker (SYK): A comparison of their dividend yield against the Health Care Equipment & Services industry group benchmark.

Dividend Payout Ratio (TTM)

Guardant Health (GH) pays no dividend (payout 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Stryker (SYK) reports a payout of 37.49%, ranking against industry peers normally.

GH

Health Care Equipment & Services industry group

0.00%

GH: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

SYK

Health Care Equipment & Services industry group

37.49%

SYK: 37.49%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

Guardant Health (GH) vs. Stryker (SYK): A comparison of their payout ratio against the Health Care Equipment & Services industry group benchmark.

Dividend Metrics

Dividend metrics for Guardant Health (GH) and Stryker (SYK)
Metric	GH	SYK
Dividend Yield (TTM)	0.00%	1.05%
Dividend Payout Ratio (TTM)	0.00%	37.49%

Valuation

P/E Ratio (TTM)

An earnings multiple is available for just one side: Stryker (SYK) trades at 34.70 times trailing earnings, ranked against its peers, while Guardant Health (GH) has no P/E ratio this period.

GH

Health Care Equipment & Services industry group

Max: 80.41
Q3: 47.62
Median: 29.93
Q1: 21.19
Min: 4.21
GH: --

SYK

Health Care Equipment & Services industry group

34.70

Max: 80.41
Q3: 47.62
SYK: 34.70
Median: 29.93
Q1: 21.19
Min: 4.21

Guardant Health (GH) vs. Stryker (SYK): GH does not report P/E ratio, so it has no value marker; SYK is benchmarked against the Health Care Equipment & Services industry group.

P/S Ratio (TTM)

Both look expensive on sales: Stryker (SYK) at 4.72 sits in the upper P/S ratio quartile, and Guardant Health (GH) at 15.96 prices even higher, above its industry range.

GH

Health Care Equipment & Services industry group

15.96

GH: 15.96
Max: 8.80
Q3: 4.32
Median: 2.13
Q1: 1.10
Min: 0.03

SYK

Health Care Equipment & Services industry group

4.72

Max: 8.80
SYK: 4.72
Q3: 4.32
Median: 2.13
Q1: 1.10
Min: 0.03

Guardant Health (GH) vs. Stryker (SYK): A comparison of their P/S ratio against the Health Care Equipment & Services industry group benchmark.

P/B Ratio (MRQ)

Guardant Health (GH) reports a negative P/B ratio of -73.67, meaning negative book equity — the multiple itself is not meaningful for valuation. Meanwhile Stryker (SYK) reports 5.29, ranking against industry peers normally.

GH

Health Care Equipment & Services industry group

-73.67

Max: 11.68
Q3: 6.12
Median: 3.00
Q1: 1.73
Min: -1.31
GH: -73.67

SYK

Health Care Equipment & Services industry group

5.29

Max: 11.68
Q3: 6.12
SYK: 5.29
Median: 3.00
Q1: 1.73
Min: -1.31

Guardant Health (GH) vs. Stryker (SYK): A comparison of their P/B ratio against the Health Care Equipment & Services industry group benchmark.

Valuation Metrics

Valuation metrics for Guardant Health (GH) and Stryker (SYK)
Metric	GH	SYK
P/E Ratio (TTM)	--	34.70
P/S Ratio (TTM)	15.96	4.72
P/B Ratio (MRQ)	-73.67	5.29
Free Cash Flow Yield (TTM)	-0.30%	2.98%