RVMD vs. TEM: Revolution Medicines vs. Tempus AI Stock Comparison

November 11, 2026

How do Revolution Medicines (RVMD) and Tempus AI (TEM) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Revolution Medicines (RVMD) and Tempus AI (TEM) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but RVMD is classified in Biotechnology while TEM is classified in Life Sciences Tools & Services.

Company profile comparison for Revolution Medicines (RVMD) and Tempus AI (TEM)
Profile Item	RVMD	TEM
Name	Revolution Medicines, Inc.	Tempus AI Inc Class A Common Stock
Country/Region	United States	United States
GICS Sector	Health Care	Health Care
GICS Industry Group	Pharmaceuticals, Biotechnology & Life Sciences	Pharmaceuticals, Biotechnology & Life Sciences
GICS Industry	Biotechnology	Life Sciences Tools & Services
GICS Sub-Industry	Biotechnology	Life Sciences Tools & Services
Market Capitalization	41.59 billion USD	13.87 billion USD
Currency	USD	USD
Exchange	Nasdaq	Nasdaq
Listing Date	February 13, 2020	June 14, 2024
Security Type	Common Stock	Common Stock

Price Performance

Cumulative Growth

RVMD

TEM

GSPC

Revolution Medicines (RVMD) vs. Tempus AI (TEM), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Revolution Medicines (RVMD) and Tempus AI (TEM). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Revolution Medicines (RVMD) and Tempus AI (TEM). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Revolution Medicines (RVMD) and Tempus AI (TEM)
Metric	RVMD	TEM
Total Return (1Y)	224.80%	16.25%
Total Return (3Y, Annualized)	114.71%	--
Total Return (5Y, Annualized)	43.47%	--

Risk Profile

Drawdown History

RVMD

TEM

GSPC

Revolution Medicines (RVMD) vs. Tempus AI (TEM), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Revolution Medicines (RVMD) and Tempus AI (TEM). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for Revolution Medicines (RVMD) and Tempus AI (TEM)
Metric	RVMD	TEM
Volatility (1Y, Annualized)	68.29%	76.08%
Beta (5Y)	1.42	3.34
Max Drawdown (5Y)	-55.71%	-59.76%
Avg. Volume (3M)	2.06M	7.20M

Risk-Adjusted Performance

Risk-Return Positioning

RVMD and TEM are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Revolution Medicines (RVMD) and Tempus AI (TEM)
Metric	RVMD	TEM
Sharpe Ratio (1Y)	3.23	0.16
Sortino Ratio (1Y)	6.92	0.26

Profitability

ROE (TTM)

Both Revolution Medicines (RVMD) at -93.56% and Tempus AI (TEM) at -37.55% report negative ROE values. Negative ROE can reflect losses or negative shareholders’ equity, so both readings need extra context.

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

-93.56%

Max: 109.18%
Q3: 6.23%
Median: -26.66%
Q1: -64.05%
RVMD: -93.56%
Min: -167.77%

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-37.55%

Max: 109.18%
Q3: 6.23%
Median: -26.66%
TEM: -37.55%
Q1: -64.05%
Min: -167.77%

Revolution Medicines (RVMD) vs. Tempus AI (TEM): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Tempus AI (TEM) reports a negative net margin of -12.54%, usually indicating a net loss over the period. Meanwhile Revolution Medicines (RVMD) reports 0.00%, ranking against industry peers normally.

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

Max: 18.05%
Q3: 4.78%
RVMD: 0.00%
Median: 0.00%
Q1: -4.14%
Min: -17.05%

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-12.54%

Max: 18.05%
Q3: 4.78%
Median: 0.00%
Q1: -4.14%
TEM: -12.54%
Min: -17.05%

Revolution Medicines (RVMD) vs. Tempus AI (TEM): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Revolution Medicines (RVMD) at -188.88% and Tempus AI (TEM) at -13.82% report negative operating margin values, usually indicating operating losses over the period.

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

-188.88%

Max: 83.12%
Q3: 14.77%
Median: 0.00%
Q1: -78.82%
RVMD: -188.88%
Min: -207.40%

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-13.82%

Max: 83.12%
Q3: 14.77%
Median: 0.00%
TEM: -13.82%
Q1: -78.82%
Min: -207.40%

Revolution Medicines (RVMD) vs. Tempus AI (TEM): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Revolution Medicines (RVMD) and Tempus AI (TEM)
Metric	RVMD	TEM
ROE (TTM)	-93.56%	-37.55%
ROA (TTM)	-32.13%	-7.36%
Net Margin (TTM)	0.00%	-12.54%
Operating Margin (TTM)	-188.88%	-13.82%
Gross Margin (TTM)	0.00%	64.46%

Growth

Revenue Growth

Only one side can be read here: Tempus AI (TEM) reports revenue growth of 83.41%, ranked against its industry; Revolution Medicines (RVMD) has no revenue growth figure this period.

Revolution Medicines (RVMD) vs. Tempus AI (TEM): A comparison of their Revenue Growth across different time periods.

EPS Growth

Neither Revolution Medicines (RVMD) nor Tempus AI (TEM) reports a EPS growth value for this period, so a direct comparison isn't possible.

Growth Metrics

Growth metrics for Revolution Medicines (RVMD) and Tempus AI (TEM)
Metric	RVMD	TEM
Revenue Growth (YoY)	--	83.41%
Revenue Growth (3Y CAGR)	--	58.29%
EPS Growth (YoY)	--	--
EPS Growth (3Y CAGR)	--	--

Financial Strength

Current Ratio (MRQ)

Both Revolution Medicines (RVMD) at 8.36 and Tempus AI (TEM) at 2.61 carry current ratio within their industries’ typical mid-ranges, suggesting balanced short-term liquidity relative to peers.

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

8.36

Max: 25.13
Q3: 12.13
RVMD: 8.36
Median: 5.52
Q1: 2.47
Min: 0.10

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.61

Max: 25.13
Q3: 12.13
Median: 5.52
TEM: 2.61
Q1: 2.47
Min: 0.10

Revolution Medicines (RVMD) vs. Tempus AI (TEM): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Revolution Medicines (RVMD) at 0.50 is near its industry mid-range for debt-to-equity ratio, while Tempus AI (TEM) at 2.86 sits above its benchmark range, pointing to a heavier debt load relative to equity.

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.50

Max: 1.42
Q3: 0.65
RVMD: 0.50
Median: 0.15
Q1: 0.02
Min: 0.00

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.86

TEM: 2.86
Max: 1.42
Q3: 0.65
Median: 0.15
Q1: 0.02
Min: 0.00

Revolution Medicines (RVMD) vs. Tempus AI (TEM): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Revolution Medicines (RVMD) and Tempus AI (TEM)
Metric	RVMD	TEM
Current Ratio (MRQ)	8.36	2.61
Debt / Equity (MRQ)	0.50	2.86
Net Debt / EBITDA	--	--

Dividends

Dividend Yield (TTM)

Neither Revolution Medicines (RVMD) nor Tempus AI (TEM) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

RVMD: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

TEM: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

Revolution Medicines (RVMD) vs. Tempus AI (TEM): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Neither Revolution Medicines (RVMD) nor Tempus AI (TEM) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

RVMD: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

TEM: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

Revolution Medicines (RVMD) vs. Tempus AI (TEM): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Revolution Medicines (RVMD) and Tempus AI (TEM)
Metric	RVMD	TEM
Dividend Yield (TTM)	0.00%	0.00%
Dividend Payout Ratio (TTM)	0.00%	0.00%

Valuation

P/E Ratio (TTM)

Neither Revolution Medicines (RVMD) nor Tempus AI (TEM) reports a P/E ratio value for this period, so a direct comparison isn’t possible.

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

Max: 85.34
Q3: 43.46
Median: 26.69
Q1: 13.30
Min: 0.07
RVMD: --

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

Max: 85.34
Q3: 43.46
Median: 26.69
Q1: 13.30
Min: 0.07
TEM: --

Revolution Medicines (RVMD) vs. Tempus AI (TEM): Neither stock reports P/E ratio, so the chart shows available benchmark boxes without value markers.

P/S Ratio (TTM)

Tempus AI (TEM) at 9.19 prices around its industry’s typical P/S ratio, while Revolution Medicines (RVMD) at 210.51 clears its benchmark range — RVMD looks notably rich on sales.

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

210.51

RVMD: 210.51
Max: 58.18
Q3: 25.77
Median: 7.30
Q1: 3.01
Min: 0.01

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

9.19

Max: 58.18
Q3: 25.77
TEM: 9.19
Median: 7.30
Q1: 3.01
Min: 0.01

Revolution Medicines (RVMD) vs. Tempus AI (TEM): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Measured against book value, both Revolution Medicines (RVMD) at 17.31 and Tempus AI (TEM) at 27.66 look expensive — each P/B ratio sits above its industry’s benchmark range.

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

17.31

RVMD: 17.31
Max: 13.53
Q3: 6.54
Median: 3.25
Q1: 1.69
Min: -5.59

TEM

Pharmaceuticals, Biotechnology & Life Sciences industry group

27.66

TEM: 27.66
Max: 13.53
Q3: 6.54
Median: 3.25
Q1: 1.69
Min: -5.59

Revolution Medicines (RVMD) vs. Tempus AI (TEM): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Revolution Medicines (RVMD) and Tempus AI (TEM)
Metric	RVMD	TEM
P/E Ratio (TTM)	--	--
P/S Ratio (TTM)	210.51	9.19
P/B Ratio (MRQ)	17.31	27.66
Free Cash Flow Yield (TTM)	-2.13%	0.30%