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NTRA vs. ONC: Natera vs. BeOne Medicines Stock Comparison

How do Natera (NTRA) and BeOne Medicines (ONC) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Natera (NTRA) and BeOne Medicines (ONC) are both classified in the Biotechnology sub-industry within the broader Biotechnology industry, placing them in the closest GICS peer bucket.

Natera (NTRA) trades as ordinary local shares, while BeOne Medicines (ONC) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.

Company profile comparison for Natera (NTRA) and BeOne Medicines (ONC)
Profile ItemNTRAONC
NameNatera, Inc.BeOne Medicines Ltd. American Depositary Shares
Country/RegionUnited StatesSwitzerland
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnologyBiotechnology
GICS Sub-IndustryBiotechnologyBiotechnology
Market Capitalization45.05 billion USD46.49 billion USD
CurrencyUSDUSD
ExchangeNasdaqNasdaq
Listing DateJuly 1, 2015February 3, 2016
Security TypeCommon StockADR

Price Performance

Cumulative Growth

NTRA
ONC
GSPC
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Natera (NTRA) vs. BeOne Medicines (ONC), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Natera (NTRA) and BeOne Medicines (ONC). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Natera (NTRA) and BeOne Medicines (ONC). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Natera (NTRA) and BeOne Medicines (ONC)
MetricNTRAONC
Total Return (1Y)61.03%30.59%
Total Return (3Y, Annualized)92.02%30.15%
Total Return (5Y, Annualized)23.20%2.48%

Risk Profile

Drawdown History

NTRA
ONC
GSPC
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Natera (NTRA) vs. BeOne Medicines (ONC), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Natera (NTRA) and BeOne Medicines (ONC). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Natera (NTRA) has an aggressive beta of 1.58, indicating higher sensitivity to broad-market moves, while BeOne Medicines (ONC) is defensive at 0.59 and tends to be less market-sensitive — they sit on opposite ends of the beta spectrum.

Risk profile metrics for Natera (NTRA) and BeOne Medicines (ONC)
MetricNTRAONC
Volatility (1Y, Annualized)52.30%35.90%
Beta (5Y)1.580.59
Max Drawdown (5Y)-75.72%-68.89%
Avg. Volume (3M)1.68M405.29K

Risk-Adjusted Performance

Risk-Return Positioning

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NTRA and ONC are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Natera (NTRA) and BeOne Medicines (ONC)
MetricNTRAONC
Sharpe Ratio (1Y)1.090.73
Sortino Ratio (1Y)1.631.15

Profitability

ROE (TTM)

Natera (NTRA) reports a negative ROE of -10.55%; negative ROE can reflect losses or negative shareholders’ equity, so it is harder to read as capital efficiency. Meanwhile BeOne Medicines (ONC) reports 18.40%, ranking against industry peers normally.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

-10.55%

Max
109.18%
Q3
6.23%
NTRA
-10.55%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

18.40%

Max
109.18%
ONC
18.40%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Natera (NTRA) vs. BeOne Medicines (ONC): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Natera (NTRA) reports a negative net margin of -5.66%, usually indicating a net loss over the period. Meanwhile BeOne Medicines (ONC) reports 13.86%, ranking against industry peers normally.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

-5.66%

Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
NTRA
-5.66%
Min
-17.05%

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

13.86%

Max
18.05%
ONC
13.86%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Natera (NTRA) vs. BeOne Medicines (ONC): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Natera (NTRA) reports a negative operating margin of -7.64%, usually indicating that operating costs exceeded revenue at the operating-income line. Meanwhile BeOne Medicines (ONC) reports 22.15%, ranking against industry peers normally.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

-7.64%

Max
83.12%
Q3
14.77%
Median
0.00%
NTRA
-7.64%
Q1
-78.82%
Min
-207.40%

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

22.15%

Max
83.12%
ONC
22.15%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Natera (NTRA) vs. BeOne Medicines (ONC): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Natera (NTRA) and BeOne Medicines (ONC)
MetricNTRAONC
ROE (TTM)-10.55%18.40%
ROA (TTM)-6.79%8.42%
Net Margin (TTM)-5.66%13.86%
Operating Margin (TTM)-7.64%22.15%
Gross Margin (TTM)65.14%89.39%

Growth

Revenue Growth

Both Natera (NTRA) at 35.90% and BeOne Medicines (ONC) at 40.23% land near their industries' usual revenue growth ranges, so top-line momentum looks broadly in line with peers on both sides.

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Natera (NTRA) vs. BeOne Medicines (ONC): A comparison of their Revenue Growth across different time periods.

EPS Growth

Neither Natera (NTRA) nor BeOne Medicines (ONC) reports a EPS growth value for this period, so a direct comparison isn't possible.

Growth Metrics

Growth metrics for Natera (NTRA) and BeOne Medicines (ONC)
MetricNTRAONC
Revenue Growth (YoY)35.90%40.23%
Revenue Growth (3Y CAGR)41.14%55.69%
EPS Growth (YoY)----
EPS Growth (3Y CAGR)----

Financial Strength

Current Ratio (MRQ)

Both Natera (NTRA) at 2.81 and BeOne Medicines (ONC) at 3.55 carry current ratio within their industries’ typical mid-ranges, suggesting balanced short-term liquidity relative to peers.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.81

Max
25.13
Q3
12.13
Median
5.52
NTRA
2.81
Q1
2.47
Min
0.10

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.55

Max
25.13
Q3
12.13
Median
5.52
ONC
3.55
Q1
2.47
Min
0.10
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Natera (NTRA) vs. BeOne Medicines (ONC): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Both Natera (NTRA) at 0.13 and BeOne Medicines (ONC) at 0.35 fund their balance sheets with roughly industry-typical debt-to-equity mixes.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.13

Max
1.42
Q3
0.65
Median
0.15
NTRA
0.13
Q1
0.02
Min
0.00

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.35

Max
1.42
Q3
0.65
ONC
0.35
Median
0.15
Q1
0.02
Min
0.00
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Natera (NTRA) vs. BeOne Medicines (ONC): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Natera (NTRA) and BeOne Medicines (ONC)
MetricNTRAONC
Current Ratio (MRQ)2.813.55
Debt / Equity (MRQ)0.130.35
Net Debt / EBITDA---2.80

Dividends

Dividend Yield (TTM)

Neither Natera (NTRA) nor BeOne Medicines (ONC) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

NTRA
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ONC
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Natera (NTRA) vs. BeOne Medicines (ONC): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Neither Natera (NTRA) nor BeOne Medicines (ONC) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

NTRA
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ONC
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Natera (NTRA) vs. BeOne Medicines (ONC): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Natera (NTRA) and BeOne Medicines (ONC)
MetricNTRAONC
Dividend Yield (TTM)0.00%0.00%
Dividend Payout Ratio (TTM)0.00%0.00%

Valuation

P/E Ratio (TTM)

An earnings multiple is available for just one side: BeOne Medicines (ONC) trades at 52.17 times trailing earnings, ranked against its peers, while Natera (NTRA) has no P/E ratio this period.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

--

Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07
NTRA
--

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

52.17

Max
85.34
ONC
52.17
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07
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Natera (NTRA) vs. BeOne Medicines (ONC): NTRA does not report P/E ratio, so it has no value marker; ONC is benchmarked against the Pharmaceuticals, Biotechnology & Life Sciences industry group.

P/S Ratio (TTM)

On P/S ratio, both Natera (NTRA) at 15.49 and BeOne Medicines (ONC) at 7.04 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

15.49

Max
58.18
Q3
25.77
NTRA
15.49
Median
7.30
Q1
3.01
Min
0.01

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.04

Max
58.18
Q3
25.77
Median
7.30
ONC
7.04
Q1
3.01
Min
0.01
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Natera (NTRA) vs. BeOne Medicines (ONC): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Both look rich against book: BeOne Medicines (ONC) at 7.98 sits in the upper P/B ratio quartile, and Natera (NTRA) at 23.99 prices even higher, above its industry range.

NTRA

Pharmaceuticals, Biotechnology & Life Sciences industry group

23.99

NTRA
23.99
Max
13.53
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.98

Max
13.53
ONC
7.98
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59
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Natera (NTRA) vs. BeOne Medicines (ONC): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Natera (NTRA) and BeOne Medicines (ONC)
MetricNTRAONC
P/E Ratio (TTM)--52.17
P/S Ratio (TTM)15.497.04
P/B Ratio (MRQ)23.997.98
Free Cash Flow Yield (TTM)0.19%2.21%