ISRG vs. PEN: Intuitive Surgical vs. Penumbra Stock Comparison

November 11, 2026

How do Intuitive Surgical (ISRG) and Penumbra (PEN) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Intuitive Surgical (ISRG) and Penumbra (PEN) are both classified in the Health Care Equipment sub-industry within the broader Health Care Equipment & Supplies industry, placing them in the closest GICS peer bucket.

Company profile comparison for Intuitive Surgical (ISRG) and Penumbra (PEN)
Profile Item	ISRG	PEN
Name	Intuitive Surgical Inc.	Penumbra Inc.
Country/Region	United States	United States
GICS Sector	Health Care	Health Care
GICS Industry Group	Health Care Equipment & Services	Health Care Equipment & Services
GICS Industry	Health Care Equipment & Supplies	Health Care Equipment & Supplies
GICS Sub-Industry	Health Care Equipment	Health Care Equipment
Market Capitalization	159.96 billion USD	12.58 billion USD
Currency	USD	USD
Exchange	Nasdaq	NYSE
Listing Date	June 16, 2000	September 18, 2015
Security Type	Common Stock	Common Stock

Price Performance

Cumulative Growth

ISRG

PEN

GSPC

Intuitive Surgical (ISRG) vs. Penumbra (PEN), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Intuitive Surgical (ISRG) and Penumbra (PEN). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Intuitive Surgical (ISRG) and Penumbra (PEN). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Intuitive Surgical (ISRG) and Penumbra (PEN)
Metric	ISRG	PEN
Total Return (1Y)	-17.61%	20.52%
Total Return (3Y, Annualized)	19.20%	20.38%
Total Return (5Y, Annualized)	4.85%	3.15%

Risk Profile

Drawdown History

ISRG

PEN

GSPC

Intuitive Surgical (ISRG) vs. Penumbra (PEN), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Intuitive Surgical (ISRG) and Penumbra (PEN). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Intuitive Surgical (ISRG) has an aggressive beta of 1.41, indicating higher sensitivity to broad-market moves, while Penumbra (PEN) is defensive at 0.68 and tends to be less market-sensitive — they sit on opposite ends of the beta spectrum.

Risk profile metrics for Intuitive Surgical (ISRG) and Penumbra (PEN)
Metric	ISRG	PEN
Volatility (1Y, Annualized)	35.53%	19.78%
Beta (5Y)	1.41	0.68
Max Drawdown (5Y)	-49.88%	-59.60%
Avg. Volume (3M)	2.43M	348.64K

Risk-Adjusted Performance

Risk-Return Positioning

ISRG and PEN are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Intuitive Surgical (ISRG) and Penumbra (PEN)
Metric	ISRG	PEN
Sharpe Ratio (1Y)	-0.62	0.82
Sortino Ratio (1Y)	-0.83	1.56

Profitability

ROE (TTM)

Intuitive Surgical (ISRG) at 17.93% sits in the top ROE quartile, while Penumbra (PEN) at 10.67% is closer to the peer norm — stronger capital efficiency for ISRG.

ISRG

Health Care Equipment & Services industry group

17.93%

Max: 47.61%
ISRG: 17.93%
Q3: 14.36%
Median: 5.45%
Q1: -10.67%
Min: -47.01%

PEN

Health Care Equipment & Services industry group

10.67%

Max: 47.61%
Q3: 14.36%
PEN: 10.67%
Median: 5.45%
Q1: -10.67%
Min: -47.01%

Intuitive Surgical (ISRG) vs. Penumbra (PEN): A comparison of their ROE against the Health Care Equipment & Services industry group benchmark.

Net Margin (TTM)

For every dollar of sales, both Intuitive Surgical (ISRG) at 25.54% and Penumbra (PEN) at 10.06% retain more as net profit than most peers, landing in the top net margin quartile of their industries.

ISRG

Health Care Equipment & Services industry group

25.54%

Max: 29.35%
ISRG: 25.54%
Q3: 9.33%
Median: 2.18%
Q1: -6.29%
Min: -28.46%

PEN

Health Care Equipment & Services industry group

10.06%

Max: 29.35%
PEN: 10.06%
Q3: 9.33%
Median: 2.18%
Q1: -6.29%
Min: -28.46%

Intuitive Surgical (ISRG) vs. Penumbra (PEN): A comparison of their net margin against the Health Care Equipment & Services industry group benchmark.

Operating Margin (TTM)

Intuitive Surgical (ISRG) at 33.29% operates in the top operating margin quartile, ahead of Penumbra (PEN) at 12.37%, which runs around its industry’s norm.

ISRG

Health Care Equipment & Services industry group

33.29%

Max: 35.43%
ISRG: 33.29%
Q3: 14.14%
Median: 6.81%
Q1: -0.28%
Min: -16.29%

PEN

Health Care Equipment & Services industry group

12.37%

Max: 35.43%
Q3: 14.14%
PEN: 12.37%
Median: 6.81%
Q1: -0.28%
Min: -16.29%

Intuitive Surgical (ISRG) vs. Penumbra (PEN): A comparison of their operating margin against the Health Care Equipment & Services industry group benchmark.

Profitability Metrics

Profitability metrics for Intuitive Surgical (ISRG) and Penumbra (PEN)
Metric	ISRG	PEN
ROE (TTM)	17.93%	10.67%
ROA (TTM)	11.86%	6.28%
Net Margin (TTM)	25.54%	10.06%
Operating Margin (TTM)	33.29%	12.37%
Gross Margin (TTM)	66.64%	67.99%

Growth

Revenue Growth

Intuitive Surgical (ISRG) at 20.51% sits in the top revenue growth quartile, while Penumbra (PEN) at 17.50% is closer to the peer norm — faster top-line expansion for ISRG.

Intuitive Surgical (ISRG) vs. Penumbra (PEN): A comparison of their Revenue Growth across different time periods.

EPS Growth

Penumbra (PEN) at 1,155.56% clears its industry range for EPS growth, a much stronger earnings trajectory than Intuitive Surgical (ISRG) at 22.59%, which is closer to a typical peer reading.

Intuitive Surgical (ISRG) vs. Penumbra (PEN): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Intuitive Surgical (ISRG) and Penumbra (PEN)
Metric	ISRG	PEN
Revenue Growth (YoY)	20.51%	17.50%
Revenue Growth (3Y CAGR)	17.39%	18.33%
EPS Growth (YoY)	22.59%	1,155.56%
EPS Growth (3Y CAGR)	29.19%	--

Financial Strength

Current Ratio (MRQ)

Intuitive Surgical (ISRG) at 3.33 keeps current ratio within its industry’s typical mid-range, while Penumbra (PEN) at 5.89 sits above its industry’s typical mid-range — comfortable liquidity, though possibly with more idle current assets relative to peers.

ISRG

Health Care Equipment & Services industry group

3.33

Max: 7.59
Q3: 4.00
ISRG: 3.33
Median: 1.98
Q1: 1.37
Min: 0.30

PEN

Health Care Equipment & Services industry group

5.89

Max: 7.59
PEN: 5.89
Q3: 4.00
Median: 1.98
Q1: 1.37
Min: 0.30

Intuitive Surgical (ISRG) vs. Penumbra (PEN): A comparison of their current ratio against the Health Care Equipment & Services industry group benchmark.

Debt / Equity (MRQ)

Only one side’s leverage can be read here: Penumbra (PEN) carries debt-to-equity ratio of 0.13 against its industry range, while Intuitive Surgical (ISRG) reports no figure this period.

ISRG

Health Care Equipment & Services industry group

Max: 1.88
Q3: 0.91
Median: 0.58
Q1: 0.16
Min: 0.00
ISRG: --

PEN

Health Care Equipment & Services industry group

0.13

Max: 1.88
Q3: 0.91
Median: 0.58
Q1: 0.16
PEN: 0.13
Min: 0.00

Intuitive Surgical (ISRG) vs. Penumbra (PEN): ISRG does not report debt-to-equity ratio, so it has no value marker; PEN is benchmarked against the Health Care Equipment & Services industry group.

Financial Strength Metrics

Financial strength metrics for Intuitive Surgical (ISRG) and Penumbra (PEN)
Metric	ISRG	PEN
Current Ratio (MRQ)	3.33	5.89
Debt / Equity (MRQ)	--	0.13
Net Debt / EBITDA	-0.90	-2.22

Dividends

Dividend Yield (TTM)

Neither Intuitive Surgical (ISRG) nor Penumbra (PEN) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

ISRG

Health Care Equipment & Services industry group

0.00%

ISRG: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

PEN

Health Care Equipment & Services industry group

0.00%

PEN: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

Intuitive Surgical (ISRG) vs. Penumbra (PEN): A comparison of their dividend yield against the Health Care Equipment & Services industry group benchmark.

Dividend Payout Ratio (TTM)

Neither Intuitive Surgical (ISRG) nor Penumbra (PEN) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

ISRG

Health Care Equipment & Services industry group

0.00%

ISRG: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

PEN

Health Care Equipment & Services industry group

0.00%

PEN: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

Intuitive Surgical (ISRG) vs. Penumbra (PEN): A comparison of their payout ratio against the Health Care Equipment & Services industry group benchmark.

Dividend Metrics

Dividend metrics for Intuitive Surgical (ISRG) and Penumbra (PEN)
Metric	ISRG	PEN
Dividend Yield (TTM)	0.00%	0.00%
Dividend Payout Ratio (TTM)	0.00%	0.00%

Valuation

P/E Ratio (TTM)

Both Intuitive Surgical (ISRG) at 54.75 and Penumbra (PEN) at 80.41 sit in the richer earnings-multiple quartile for P/E ratio, so investors are paying more for TTM earnings than they pay for typical peers.

ISRG

Health Care Equipment & Services industry group

54.75

Max: 80.41
ISRG: 54.75
Q3: 47.62
Median: 29.93
Q1: 21.19
Min: 4.21

PEN

Health Care Equipment & Services industry group

80.41

PEN: 80.41
Max: 80.41
Q3: 47.62
Median: 29.93
Q1: 21.19
Min: 4.21

Intuitive Surgical (ISRG) vs. Penumbra (PEN): A comparison of their P/E ratio against the Health Care Equipment & Services industry group benchmark.

P/S Ratio (TTM)

Both look expensive on sales: Penumbra (PEN) at 8.06 sits in the upper P/S ratio quartile, and Intuitive Surgical (ISRG) at 13.82 prices even higher, above its industry range.

ISRG

Health Care Equipment & Services industry group

13.82

ISRG: 13.82
Max: 8.80
Q3: 4.32
Median: 2.13
Q1: 1.10
Min: 0.03

PEN

Health Care Equipment & Services industry group

8.06

Max: 8.80
PEN: 8.06
Q3: 4.32
Median: 2.13
Q1: 1.10
Min: 0.03

Intuitive Surgical (ISRG) vs. Penumbra (PEN): A comparison of their P/S ratio against the Health Care Equipment & Services industry group benchmark.

P/B Ratio (MRQ)

Both Intuitive Surgical (ISRG) at 9.82 and Penumbra (PEN) at 7.95 carry a premium to book value versus peers, sitting in the upper P/B ratio quartile of their industries.

ISRG

Health Care Equipment & Services industry group

9.82

Max: 11.68
ISRG: 9.82
Q3: 6.12
Median: 3.00
Q1: 1.73
Min: -1.31

PEN

Health Care Equipment & Services industry group

7.95

Max: 11.68
PEN: 7.95
Q3: 6.12
Median: 3.00
Q1: 1.73
Min: -1.31

Intuitive Surgical (ISRG) vs. Penumbra (PEN): A comparison of their P/B ratio against the Health Care Equipment & Services industry group benchmark.

Valuation Metrics

Valuation metrics for Intuitive Surgical (ISRG) and Penumbra (PEN)
Metric	ISRG	PEN
P/E Ratio (TTM)	54.75	80.41
P/S Ratio (TTM)	13.82	8.06
P/B Ratio (MRQ)	9.82	7.95
Free Cash Flow Yield (TTM)	2.15%	1.32%