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GH vs. MDLN: Guardant Health vs. Medline Stock Comparison

How do Guardant Health (GH) and Medline (MDLN) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Guardant Health (GH) and Medline (MDLN) both fall under the Health Care Equipment & Services industry group, but GH is classified in Health Care Providers & Services while MDLN is classified in Health Care Equipment & Supplies.

Guardant Health (GH) has been public since October 4, 2018 with a meaningfully longer listed history, while Medline (MDLN) only listed on December 17, 2025 — long-window metrics on the MDLN side should be interpreted with caution.

Company profile comparison for Guardant Health (GH) and Medline (MDLN)
Profile ItemGHMDLN
NameGuardant Health, Inc.Medline Inc. Class A Common Stock
Country/RegionUnited StatesUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupHealth Care Equipment & ServicesHealth Care Equipment & Services
GICS IndustryHealth Care Providers & ServicesHealth Care Equipment & Supplies
GICS Sub-IndustryHealth Care ServicesHealth Care Supplies
Market Capitalization20.41 billion USD52.17 billion USD
CurrencyUSDUSD
ExchangeNasdaqNasdaq
Listing DateOctober 4, 2018December 17, 2025
Security TypeCommon StockCommon Stock

Price Performance

Cumulative Growth

GH
MDLN
GSPC
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Guardant Health (GH) vs. Medline (MDLN), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Guardant Health (GH) and Medline (MDLN). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Guardant Health (GH) and Medline (MDLN). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Guardant Health (GH) and Medline (MDLN)
MetricGHMDLN
Total Return (1Y)66.53%--
Total Return (3Y, Annualized)92.76%--
Total Return (5Y, Annualized)8.36%--

Risk Profile

Drawdown History

GH
MDLN
GSPC
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Guardant Health (GH) vs. Medline (MDLN), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Guardant Health (GH) and Medline (MDLN). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Medline (MDLN) reports a negative beta of -0.93, suggesting inverse market sensitivity over the measurement window. That is uncommon for ordinary equities and can reflect commodity-linked or hedge-like exposure, but it can also come from statistical noise. Guardant Health (GH) has a non-negative beta of 1.69.

Risk profile metrics for Guardant Health (GH) and Medline (MDLN)
MetricGHMDLN
Volatility (1Y, Annualized)53.23%47.93%
Beta (5Y)1.69-0.93
Max Drawdown (5Y)-85.09%-36.71%
Avg. Volume (3M)1.97M8.63M

Risk-Adjusted Performance

Risk-Return Positioning

Both GH and MDLN need 1-year volatility and 1-year return to plot risk-return positioning.

Risk-Adjusted Metrics

Risk-adjusted metrics for Guardant Health (GH) and Medline (MDLN)
MetricGHMDLN
Sharpe Ratio (1Y)1.17--
Sortino Ratio (1Y)1.84--

Profitability

ROE (TTM)

Capital efficiency shows on one side only: Medline (MDLN) earns 4.85% on shareholders’ equity, ranked against its industry; Guardant Health (GH) has no ROE this period.

GH

Health Care Equipment & Services industry group

--

Max
47.61%
Q3
14.36%
Median
5.45%
Q1
-10.67%
Min
-47.01%
GH
--

MDLN

Health Care Equipment & Services industry group

4.85%

Max
47.61%
Q3
14.36%
Median
5.45%
MDLN
4.85%
Q1
-10.67%
Min
-47.01%
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Guardant Health (GH) vs. Medline (MDLN): GH does not report ROE, so it has no value marker; MDLN is benchmarked against the Health Care Equipment & Services industry group.

Net Margin (TTM)

Guardant Health (GH) reports a negative net margin of -37.93%, usually indicating a net loss over the period. Meanwhile Medline (MDLN) reports 1.85%, ranking against industry peers normally.

GH

Health Care Equipment & Services industry group

-37.93%

Max
29.35%
Q3
9.33%
Median
2.18%
Q1
-6.29%
Min
-28.46%
GH
-37.93%

MDLN

Health Care Equipment & Services industry group

1.85%

Max
29.35%
Q3
9.33%
Median
2.18%
MDLN
1.85%
Q1
-6.29%
Min
-28.46%
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Guardant Health (GH) vs. Medline (MDLN): A comparison of their net margin against the Health Care Equipment & Services industry group benchmark.

Operating Margin (TTM)

Guardant Health (GH) reports a negative operating margin of -37.06%, usually indicating that operating costs exceeded revenue at the operating-income line. Meanwhile Medline (MDLN) reports 5.22%, ranking against industry peers normally.

GH

Health Care Equipment & Services industry group

-37.06%

Max
35.43%
Q3
14.14%
Median
6.81%
Q1
-0.28%
Min
-16.29%
GH
-37.06%

MDLN

Health Care Equipment & Services industry group

5.22%

Max
35.43%
Q3
14.14%
Median
6.81%
MDLN
5.22%
Q1
-0.28%
Min
-16.29%
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Guardant Health (GH) vs. Medline (MDLN): A comparison of their operating margin against the Health Care Equipment & Services industry group benchmark.

Profitability Metrics

Profitability metrics for Guardant Health (GH) and Medline (MDLN)
MetricGHMDLN
ROE (TTM)--4.85%
ROA (TTM)-19.92%2.70%
Net Margin (TTM)-37.93%1.85%
Operating Margin (TTM)-37.06%5.22%
Gross Margin (TTM)65.19%24.42%

Growth

Revenue Growth

Only one side can be read here: Guardant Health (GH) reports revenue growth of 32.88%, ranked against its industry; Medline (MDLN) has no revenue growth figure this period.

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Guardant Health (GH) vs. Medline (MDLN): A comparison of their Revenue Growth across different time periods.

EPS Growth

Only one side can be read here: Medline (MDLN) reports EPS growth of 117.38%, ranked against its industry; Guardant Health (GH) has no EPS growth figure this period.

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Guardant Health (GH) vs. Medline (MDLN): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Guardant Health (GH) and Medline (MDLN)
MetricGHMDLN
Revenue Growth (YoY)32.88%--
Revenue Growth (3Y CAGR)29.75%--
EPS Growth (YoY)--117.38%
EPS Growth (3Y CAGR)----

Financial Strength

Current Ratio (MRQ)

Guardant Health (GH) at 3.60 keeps current ratio within its industry’s typical mid-range, while Medline (MDLN) at 4.04 sits above its industry’s typical mid-range — comfortable liquidity, though possibly with more idle current assets relative to peers.

GH

Health Care Equipment & Services industry group

3.60

Max
7.59
Q3
4.00
GH
3.60
Median
1.98
Q1
1.37
Min
0.30

MDLN

Health Care Equipment & Services industry group

4.04

Max
7.59
MDLN
4.04
Q3
4.00
Median
1.98
Q1
1.37
Min
0.30
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Guardant Health (GH) vs. Medline (MDLN): A comparison of their current ratio against the Health Care Equipment & Services industry group benchmark.

Debt / Equity (MRQ)

Only one side’s leverage can be read here: Medline (MDLN) carries debt-to-equity ratio of 0.65 against its industry range, while Guardant Health (GH) reports no figure this period.

GH

Health Care Equipment & Services industry group

--

Max
1.88
Q3
0.91
Median
0.58
Q1
0.16
Min
0.00
GH
--

MDLN

Health Care Equipment & Services industry group

0.65

Max
1.88
Q3
0.91
MDLN
0.65
Median
0.58
Q1
0.16
Min
0.00
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Guardant Health (GH) vs. Medline (MDLN): GH does not report debt-to-equity ratio, so it has no value marker; MDLN is benchmarked against the Health Care Equipment & Services industry group.

Financial Strength Metrics

Financial strength metrics for Guardant Health (GH) and Medline (MDLN)
MetricGHMDLN
Current Ratio (MRQ)3.604.04
Debt / Equity (MRQ)--0.65
Net Debt / EBITDA--3.35

Dividends

Dividend Yield (TTM)

Neither Guardant Health (GH) nor Medline (MDLN) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

GH

Health Care Equipment & Services industry group

0.00%

GH
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

MDLN

Health Care Equipment & Services industry group

0.00%

MDLN
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Guardant Health (GH) vs. Medline (MDLN): A comparison of their dividend yield against the Health Care Equipment & Services industry group benchmark.

Dividend Payout Ratio (TTM)

Neither Guardant Health (GH) nor Medline (MDLN) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

GH

Health Care Equipment & Services industry group

0.00%

GH
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

MDLN

Health Care Equipment & Services industry group

0.00%

MDLN
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Guardant Health (GH) vs. Medline (MDLN): A comparison of their payout ratio against the Health Care Equipment & Services industry group benchmark.

Dividend Metrics

Dividend metrics for Guardant Health (GH) and Medline (MDLN)
MetricGHMDLN
Dividend Yield (TTM)0.00%0.00%
Dividend Payout Ratio (TTM)0.00%0.00%

Valuation

P/E Ratio (TTM)

An earnings multiple is available for just one side: Medline (MDLN) trades at 90.09 times trailing earnings, ranked against its peers, while Guardant Health (GH) has no P/E ratio this period.

GH

Health Care Equipment & Services industry group

--

Max
80.41
Q3
47.62
Median
29.93
Q1
21.19
Min
4.21
GH
--

MDLN

Health Care Equipment & Services industry group

90.09

MDLN
90.09
Max
80.41
Q3
47.62
Median
29.93
Q1
21.19
Min
4.21
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Guardant Health (GH) vs. Medline (MDLN): GH does not report P/E ratio, so it has no value marker; MDLN is benchmarked against the Health Care Equipment & Services industry group.

P/S Ratio (TTM)

Medline (MDLN) at 1.70 prices around its industry’s typical P/S ratio, while Guardant Health (GH) at 15.96 clears its benchmark range — GH looks notably rich on sales.

GH

Health Care Equipment & Services industry group

15.96

GH
15.96
Max
8.80
Q3
4.32
Median
2.13
Q1
1.10
Min
0.03

MDLN

Health Care Equipment & Services industry group

1.70

Max
8.80
Q3
4.32
Median
2.13
MDLN
1.70
Q1
1.10
Min
0.03
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Guardant Health (GH) vs. Medline (MDLN): A comparison of their P/S ratio against the Health Care Equipment & Services industry group benchmark.

P/B Ratio (MRQ)

Guardant Health (GH) reports a negative P/B ratio of -73.67, meaning negative book equity — the multiple itself is not meaningful for valuation. Meanwhile Medline (MDLN) reports 2.95, ranking against industry peers normally.

GH

Health Care Equipment & Services industry group

-73.67

Max
11.68
Q3
6.12
Median
3.00
Q1
1.73
Min
-1.31
GH
-73.67

MDLN

Health Care Equipment & Services industry group

2.95

Max
11.68
Q3
6.12
Median
3.00
MDLN
2.95
Q1
1.73
Min
-1.31
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Guardant Health (GH) vs. Medline (MDLN): A comparison of their P/B ratio against the Health Care Equipment & Services industry group benchmark.

Valuation Metrics

Valuation metrics for Guardant Health (GH) and Medline (MDLN)
MetricGHMDLN
P/E Ratio (TTM)--90.09
P/S Ratio (TTM)15.961.70
P/B Ratio (MRQ)-73.672.95
Free Cash Flow Yield (TTM)-0.30%2.67%