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PFE vs. REGN: Pfizer vs. Regeneron Pharmaceuticals Stock Comparison

How do Pfizer (PFE) and Regeneron Pharmaceuticals (REGN) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Pfizer (PFE) and Regeneron Pharmaceuticals (REGN) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but PFE is classified in Pharmaceuticals while REGN is classified in Biotechnology.

Company profile comparison for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN)
Profile ItemPFEREGN
NamePfizer Inc.Regeneron Pharmaceuticals, Inc.
Country/RegionUnited StatesUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryPharmaceuticalsBiotechnology
GICS Sub-IndustryPharmaceuticalsBiotechnology
Market Capitalization167.52 billion USD93.55 billion USD
CurrencyUSDUSD
ExchangeNYSENasdaq
Listing DateJune 1, 1972April 2, 1991
Security TypeCommon StockCommon Stock

Price Performance

Cumulative Growth

PFE
REGN
GSPC
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN)
MetricPFEREGN
Total Return (1Y)28.65%40.87%
Total Return (3Y, Annualized)6.41%5.15%
Total Return (5Y, Annualized)-3.98%8.58%

Risk Profile

Drawdown History

PFE
REGN
GSPC
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Pfizer (PFE) is heavily traded at around 33.67M shares per day, whereas Regeneron Pharmaceuticals (REGN) sees a more moderate 772.95K — larger orders in the latter may require more patience and tighter control over order sizing.

Risk profile metrics for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN)
MetricPFEREGN
Volatility (1Y, Annualized)21.72%34.08%
Beta (5Y)0.350.10
Max Drawdown (5Y)-58.96%-59.69%
Avg. Volume (3M)33.67M772.95K

Risk-Adjusted Performance

Risk-Return Positioning

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PFE and REGN are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN)
MetricPFEREGN
Sharpe Ratio (1Y)1.121.07
Sortino Ratio (1Y)1.731.70

Profitability

ROE (TTM)

Regeneron Pharmaceuticals (REGN) at 14.95% sits in the top ROE quartile, while Pfizer (PFE) at 4.47% is closer to the peer norm — stronger capital efficiency for REGN.

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.47%

Max
109.18%
Q3
6.23%
PFE
4.47%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

14.95%

Max
109.18%
REGN
14.95%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Regeneron Pharmaceuticals (REGN) at 28.51% keeps the most of each sales dollar — above its industry’s net margin range — and Pfizer (PFE) at 6.34% also retains a top-quartile share.

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

6.34%

Max
18.05%
PFE
6.34%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

28.51%

REGN
28.51%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Pfizer (PFE) at 33.38% and Regeneron Pharmaceuticals (REGN) at 40.46% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

33.38%

Max
83.12%
PFE
33.38%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

40.46%

Max
83.12%
REGN
40.46%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN)
MetricPFEREGN
ROE (TTM)4.47%14.95%
ROA (TTM)5.59%7.59%
Net Margin (TTM)6.34%28.51%
Operating Margin (TTM)33.38%40.46%
Gross Margin (TTM)74.90%46.73%

Growth

Revenue Growth

Regeneron Pharmaceuticals (REGN) at 0.99% is around its peer norm for revenue growth, while Pfizer (PFE) at -1.65% drops into the bottom quartile, signaling weaker demand or pricing momentum.

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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their Revenue Growth across different time periods.

EPS Growth

Both Pfizer (PFE) at -3.55% and Regeneron Pharmaceuticals (REGN) at 8.19% land near their industries' usual EPS growth ranges, so bottom-line momentum looks broadly in line with peers on both sides.

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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN)
MetricPFEREGN
Revenue Growth (YoY)-1.65%0.99%
Revenue Growth (3Y CAGR)-14.80%5.62%
EPS Growth (YoY)-3.55%8.19%
EPS Growth (3Y CAGR)-37.12%2.77%

Financial Strength

Current Ratio (MRQ)

Regeneron Pharmaceuticals (REGN) at 3.35 keeps current ratio within its industry’s typical mid-range, while Pfizer (PFE) at 1.42 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for PFE.

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.42

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
PFE
1.42
Min
0.10

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.35

Max
25.13
Q3
12.13
Median
5.52
REGN
3.35
Q1
2.47
Min
0.10
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Regeneron Pharmaceuticals (REGN) at 0.08 carries an industry-typical debt-to-equity mix, while Pfizer (PFE) at 0.71 uses more debt funding than most peers.

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.71

Max
1.42
PFE
0.71
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.08

Max
1.42
Q3
0.65
Median
0.15
REGN
0.08
Q1
0.02
Min
0.00
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN)
MetricPFEREGN
Current Ratio (MRQ)1.423.35
Debt / Equity (MRQ)0.710.08
Net Debt / EBITDA1.97-1.17

Dividends

Dividend Yield (TTM)

Both Pfizer (PFE) at 7.30% and Regeneron Pharmaceuticals (REGN) at 0.41% yield above their industries’ entire benchmark ranges — high enough that dividend safety, not income, becomes the first question.

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.30%

PFE
7.30%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.41%

REGN
0.41%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Pfizer (PFE) reports payout ratio above 100% at 245.71%, meaning dividends exceeded current-period earnings and sustainability needs extra context. Meanwhile Regeneron Pharmaceuticals (REGN) reports 8.18%, ranking against industry peers normally.

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

245.71%

PFE
245.71%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

8.18%

REGN
8.18%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN)
MetricPFEREGN
Dividend Yield (TTM)7.30%0.41%
Dividend Payout Ratio (TTM)245.71%8.18%

Valuation

P/E Ratio (TTM)

Both Pfizer (PFE) at 41.99 and Regeneron Pharmaceuticals (REGN) at 19.99 land around their industries’ usual P/E ratio levels — neither is getting a clear earnings-multiple discount or premium versus peers.

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

41.99

Max
85.34
Q3
43.46
PFE
41.99
Median
26.69
Q1
13.30
Min
0.07

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

19.99

Max
85.34
Q3
43.46
Median
26.69
REGN
19.99
Q1
13.30
Min
0.07
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

Pfizer (PFE) at 2.63 sits in the cheaper P/S ratio quartile while Regeneron Pharmaceuticals (REGN) at 5.54 prices around its industry’s middle — PFE costs less per dollar of sales, though read it alongside growth and margins.

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.63

Max
58.18
Q3
25.77
Median
7.30
Q1
3.01
PFE
2.63
Min
0.01

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.54

Max
58.18
Q3
25.77
Median
7.30
REGN
5.54
Q1
3.01
Min
0.01
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

On P/B ratio, both Pfizer (PFE) at 1.88 and Regeneron Pharmaceuticals (REGN) at 2.71 are valued close to their industries’ norm against book — neither stands out from peers.

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.88

Max
13.53
Q3
6.54
Median
3.25
PFE
1.88
Q1
1.69
Min
-5.59

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.71

Max
13.53
Q3
6.54
Median
3.25
REGN
2.71
Q1
1.69
Min
-5.59
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Pfizer (PFE) vs. Regeneron Pharmaceuticals (REGN): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Pfizer (PFE) and Regeneron Pharmaceuticals (REGN)
MetricPFEREGN
P/E Ratio (TTM)41.9919.99
P/S Ratio (TTM)2.635.54
P/B Ratio (MRQ)1.882.71
Free Cash Flow Yield (TTM)7.76%2.76%