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ONC vs. PFE: BeOne Medicines vs. Pfizer Stock Comparison

How do BeOne Medicines (ONC) and Pfizer (PFE) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

BeOne Medicines (ONC) and Pfizer (PFE) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but ONC is classified in Biotechnology while PFE is classified in Pharmaceuticals.

Pfizer (PFE) trades as ordinary local shares, while BeOne Medicines (ONC) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.

Company profile comparison for BeOne Medicines (ONC) and Pfizer (PFE)
Profile ItemONCPFE
NameBeOne Medicines Ltd. American Depositary SharesPfizer Inc.
Country/RegionSwitzerlandUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnologyPharmaceuticals
GICS Sub-IndustryBiotechnologyPharmaceuticals
Market Capitalization46.49 billion USD167.52 billion USD
CurrencyUSDUSD
ExchangeNasdaqNYSE
Listing DateFebruary 3, 2016June 1, 1972
Security TypeADRCommon Stock

Price Performance

Cumulative Growth

ONC
PFE
GSPC
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BeOne Medicines (ONC) vs. Pfizer (PFE), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for BeOne Medicines (ONC) and Pfizer (PFE). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for BeOne Medicines (ONC) and Pfizer (PFE). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for BeOne Medicines (ONC) and Pfizer (PFE)
MetricONCPFE
Total Return (1Y)30.59%28.65%
Total Return (3Y, Annualized)30.15%6.41%
Total Return (5Y, Annualized)2.48%-3.98%

Risk Profile

Drawdown History

ONC
PFE
GSPC
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BeOne Medicines (ONC) vs. Pfizer (PFE), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for BeOne Medicines (ONC) and Pfizer (PFE). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Pfizer (PFE) is heavily traded at around 33.67M shares per day, whereas BeOne Medicines (ONC) sees a more moderate 405.29K — larger orders in the latter may require more patience and tighter control over order sizing.

Risk profile metrics for BeOne Medicines (ONC) and Pfizer (PFE)
MetricONCPFE
Volatility (1Y, Annualized)35.90%21.72%
Beta (5Y)0.590.35
Max Drawdown (5Y)-68.89%-58.96%
Avg. Volume (3M)405.29K33.67M

Risk-Adjusted Performance

Risk-Return Positioning

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ONC and PFE are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for BeOne Medicines (ONC) and Pfizer (PFE)
MetricONCPFE
Sharpe Ratio (1Y)0.731.12
Sortino Ratio (1Y)1.151.73

Profitability

ROE (TTM)

BeOne Medicines (ONC) at 18.40% sits in the top ROE quartile, while Pfizer (PFE) at 4.47% is closer to the peer norm — stronger capital efficiency for ONC.

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

18.40%

Max
109.18%
ONC
18.40%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.47%

Max
109.18%
Q3
6.23%
PFE
4.47%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

For every dollar of sales, both BeOne Medicines (ONC) at 13.86% and Pfizer (PFE) at 6.34% retain more as net profit than most peers, landing in the top net margin quartile of their industries.

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

13.86%

Max
18.05%
ONC
13.86%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

6.34%

Max
18.05%
PFE
6.34%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both BeOne Medicines (ONC) at 22.15% and Pfizer (PFE) at 33.38% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

22.15%

Max
83.12%
ONC
22.15%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

33.38%

Max
83.12%
PFE
33.38%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for BeOne Medicines (ONC) and Pfizer (PFE)
MetricONCPFE
ROE (TTM)18.40%4.47%
ROA (TTM)8.42%5.59%
Net Margin (TTM)13.86%6.34%
Operating Margin (TTM)22.15%33.38%
Gross Margin (TTM)89.39%74.90%

Growth

Revenue Growth

BeOne Medicines (ONC) at 40.23% is around its peer norm for revenue growth, while Pfizer (PFE) at -1.65% drops into the bottom quartile, signaling weaker demand or pricing momentum.

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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their Revenue Growth across different time periods.

EPS Growth

Only one side can be read here: Pfizer (PFE) reports EPS growth of -3.55%, ranked against its industry; BeOne Medicines (ONC) has no EPS growth figure this period.

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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for BeOne Medicines (ONC) and Pfizer (PFE)
MetricONCPFE
Revenue Growth (YoY)40.23%-1.65%
Revenue Growth (3Y CAGR)55.69%-14.80%
EPS Growth (YoY)---3.55%
EPS Growth (3Y CAGR)---37.12%

Financial Strength

Current Ratio (MRQ)

BeOne Medicines (ONC) at 3.55 keeps current ratio within its industry’s typical mid-range, while Pfizer (PFE) at 1.42 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for PFE.

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.55

Max
25.13
Q3
12.13
Median
5.52
ONC
3.55
Q1
2.47
Min
0.10

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.42

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
PFE
1.42
Min
0.10
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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

BeOne Medicines (ONC) at 0.35 carries an industry-typical debt-to-equity mix, while Pfizer (PFE) at 0.71 uses more debt funding than most peers.

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.35

Max
1.42
Q3
0.65
ONC
0.35
Median
0.15
Q1
0.02
Min
0.00

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.71

Max
1.42
PFE
0.71
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for BeOne Medicines (ONC) and Pfizer (PFE)
MetricONCPFE
Current Ratio (MRQ)3.551.42
Debt / Equity (MRQ)0.350.71
Net Debt / EBITDA-2.801.97

Dividends

Dividend Yield (TTM)

BeOne Medicines (ONC) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Pfizer (PFE) reports a yield of 7.30%, ranking against industry peers normally.

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ONC
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.30%

PFE
7.30%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Pfizer (PFE) reports payout ratio above 100% at 245.71%, meaning dividends exceeded current-period earnings; BeOne Medicines (ONC) pays no dividend (payout 0.00%).

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ONC
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

245.71%

PFE
245.71%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for BeOne Medicines (ONC) and Pfizer (PFE)
MetricONCPFE
Dividend Yield (TTM)0.00%7.30%
Dividend Payout Ratio (TTM)0.00%245.71%

Valuation

P/E Ratio (TTM)

Pfizer (PFE) at 41.99 is near its industry’s usual P/E ratio, while BeOne Medicines (ONC) at 52.17 sits in the richer quartile — ONC needs stronger growth or earnings quality to justify the premium.

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

52.17

Max
85.34
ONC
52.17
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

41.99

Max
85.34
Q3
43.46
PFE
41.99
Median
26.69
Q1
13.30
Min
0.07
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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

Pfizer (PFE) at 2.63 sits in the cheaper P/S ratio quartile while BeOne Medicines (ONC) at 7.04 prices around its industry’s middle — PFE costs less per dollar of sales, though read it alongside growth and margins.

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.04

Max
58.18
Q3
25.77
Median
7.30
ONC
7.04
Q1
3.01
Min
0.01

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.63

Max
58.18
Q3
25.77
Median
7.30
Q1
3.01
PFE
2.63
Min
0.01
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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Pfizer (PFE) at 1.88 is valued about in line with its industry on P/B ratio, while BeOne Medicines (ONC) at 7.98 carries an above-peer premium to book — ONC is pricier on assets.

ONC

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.98

Max
13.53
ONC
7.98
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.88

Max
13.53
Q3
6.54
Median
3.25
PFE
1.88
Q1
1.69
Min
-5.59
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BeOne Medicines (ONC) vs. Pfizer (PFE): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for BeOne Medicines (ONC) and Pfizer (PFE)
MetricONCPFE
P/E Ratio (TTM)52.1741.99
P/S Ratio (TTM)7.042.63
P/B Ratio (MRQ)7.981.88
Free Cash Flow Yield (TTM)2.21%7.76%