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MRK vs. REGN: Merck vs. Regeneron Pharmaceuticals Stock Comparison

How do Merck (MRK) and Regeneron Pharmaceuticals (REGN) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Merck (MRK) and Regeneron Pharmaceuticals (REGN) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but MRK is classified in Pharmaceuticals while REGN is classified in Biotechnology.

Company profile comparison for Merck (MRK) and Regeneron Pharmaceuticals (REGN)
Profile ItemMRKREGN
NameMerck & Co., Inc.Regeneron Pharmaceuticals, Inc.
Country/RegionUnited StatesUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryPharmaceuticalsBiotechnology
GICS Sub-IndustryPharmaceuticalsBiotechnology
Market Capitalization361.73 billion USD93.55 billion USD
CurrencyUSDUSD
ExchangeNYSENasdaq
Listing DateJanuary 2, 1962April 2, 1991
Security TypeCommon StockCommon Stock

Price Performance

Cumulative Growth

MRK
REGN
GSPC
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Merck (MRK) and Regeneron Pharmaceuticals (REGN). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Merck (MRK) and Regeneron Pharmaceuticals (REGN). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Merck (MRK) and Regeneron Pharmaceuticals (REGN)
MetricMRKREGN
Total Return (1Y)76.14%40.87%
Total Return (3Y, Annualized)16.48%5.15%
Total Return (5Y, Annualized)15.77%8.58%

Risk Profile

Drawdown History

MRK
REGN
GSPC
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Merck (MRK) and Regeneron Pharmaceuticals (REGN). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Merck (MRK) is heavily traded at around 10.24M shares per day, whereas Regeneron Pharmaceuticals (REGN) sees a more moderate 772.95K — larger orders in the latter may require more patience and tighter control over order sizing.

Risk profile metrics for Merck (MRK) and Regeneron Pharmaceuticals (REGN)
MetricMRKREGN
Volatility (1Y, Annualized)30.24%34.08%
Beta (5Y)0.110.10
Max Drawdown (5Y)-43.44%-59.69%
Avg. Volume (3M)10.24M772.95K

Risk-Adjusted Performance

Risk-Return Positioning

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MRK and REGN are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Merck (MRK) and Regeneron Pharmaceuticals (REGN)
MetricMRKREGN
Sharpe Ratio (1Y)2.381.07
Sortino Ratio (1Y)4.331.70

Profitability

ROE (TTM)

Regeneron Pharmaceuticals (REGN) at 14.95% sits in the top ROE quartile, while Merck (MRK) at 5.06% is closer to the peer norm — stronger capital efficiency for REGN.

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.06%

Max
109.18%
Q3
6.23%
MRK
5.06%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

14.95%

Max
109.18%
REGN
14.95%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Regeneron Pharmaceuticals (REGN) at 28.51% converts revenue to bottom-line profit above its industry’s benchmark range, while Merck (MRK) at 3.64% keeps roughly the typical share for its industry.

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.64%

Max
18.05%
Q3
4.78%
MRK
3.64%
Median
0.00%
Q1
-4.14%
Min
-17.05%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

28.51%

REGN
28.51%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Merck (MRK) at 35.22% and Regeneron Pharmaceuticals (REGN) at 40.46% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

35.22%

Max
83.12%
MRK
35.22%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

40.46%

Max
83.12%
REGN
40.46%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Merck (MRK) and Regeneron Pharmaceuticals (REGN)
MetricMRKREGN
ROE (TTM)5.06%14.95%
ROA (TTM)11.29%7.59%
Net Margin (TTM)3.64%28.51%
Operating Margin (TTM)35.22%40.46%
Gross Margin (TTM)75.20%46.73%

Growth

Revenue Growth

Both Merck (MRK) at 1.31% and Regeneron Pharmaceuticals (REGN) at 0.99% land near their industries' usual revenue growth ranges, so top-line momentum looks broadly in line with peers on both sides.

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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their Revenue Growth across different time periods.

EPS Growth

Both Merck (MRK) at 8.01% and Regeneron Pharmaceuticals (REGN) at 8.19% land near their industries' usual EPS growth ranges, so bottom-line momentum looks broadly in line with peers on both sides.

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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Merck (MRK) and Regeneron Pharmaceuticals (REGN)
MetricMRKREGN
Revenue Growth (YoY)1.31%0.99%
Revenue Growth (3Y CAGR)3.12%5.62%
EPS Growth (YoY)8.01%8.19%
EPS Growth (3Y CAGR)8.43%2.77%

Financial Strength

Current Ratio (MRQ)

Regeneron Pharmaceuticals (REGN) at 3.35 keeps current ratio within its industry’s typical mid-range, while Merck (MRK) at 1.35 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for MRK.

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.35

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
MRK
1.35
Min
0.10

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.35

Max
25.13
Q3
12.13
Median
5.52
REGN
3.35
Q1
2.47
Min
0.10
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Regeneron Pharmaceuticals (REGN) at 0.08 carries an industry-typical debt-to-equity mix, while Merck (MRK) at 1.20 uses more debt funding than most peers.

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.20

Max
1.42
MRK
1.20
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.08

Max
1.42
Q3
0.65
Median
0.15
REGN
0.08
Q1
0.02
Min
0.00
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Merck (MRK) and Regeneron Pharmaceuticals (REGN)
MetricMRKREGN
Current Ratio (MRQ)1.353.35
Debt / Equity (MRQ)1.200.08
Net Debt / EBITDA1.50-1.17

Dividends

Dividend Yield (TTM)

Both Merck (MRK) at 2.29% and Regeneron Pharmaceuticals (REGN) at 0.41% yield above their industries’ entire benchmark ranges — high enough that dividend safety, not income, becomes the first question.

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.29%

MRK
2.29%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.41%

REGN
0.41%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Merck (MRK) reports payout ratio above 100% at 343.43%, meaning dividends exceeded current-period earnings and sustainability needs extra context. Meanwhile Regeneron Pharmaceuticals (REGN) reports 8.18%, ranking against industry peers normally.

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

343.43%

MRK
343.43%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

8.18%

REGN
8.18%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Merck (MRK) and Regeneron Pharmaceuticals (REGN)
MetricMRKREGN
Dividend Yield (TTM)2.29%0.41%
Dividend Payout Ratio (TTM)343.43%8.18%

Valuation

P/E Ratio (TTM)

Regeneron Pharmaceuticals (REGN) at 19.99 is near its industry’s usual P/E ratio, while Merck (MRK) at 148.21 sits above its peer range — an unusually expensive price for MRK’s trailing earnings.

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

148.21

MRK
148.21
Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

19.99

Max
85.34
Q3
43.46
Median
26.69
REGN
19.99
Q1
13.30
Min
0.07
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

On P/S ratio, both Merck (MRK) at 5.37 and Regeneron Pharmaceuticals (REGN) at 5.54 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.37

Max
58.18
Q3
25.77
Median
7.30
MRK
5.37
Q1
3.01
Min
0.01

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.54

Max
58.18
Q3
25.77
Median
7.30
REGN
5.54
Q1
3.01
Min
0.01
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Regeneron Pharmaceuticals (REGN) at 2.71 is valued about in line with its industry on P/B ratio, while Merck (MRK) at 8.06 carries an above-peer premium to book — MRK is pricier on assets.

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

8.06

Max
13.53
MRK
8.06
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.71

Max
13.53
Q3
6.54
Median
3.25
REGN
2.71
Q1
1.69
Min
-5.59
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Merck (MRK) vs. Regeneron Pharmaceuticals (REGN): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Merck (MRK) and Regeneron Pharmaceuticals (REGN)
MetricMRKREGN
P/E Ratio (TTM)148.2119.99
P/S Ratio (TTM)5.375.54
P/B Ratio (MRQ)8.062.71
Free Cash Flow Yield (TTM)3.88%2.76%