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INSM vs. PFE: Insmed vs. Pfizer Stock Comparison

How do Insmed (INSM) and Pfizer (PFE) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Insmed (INSM) and Pfizer (PFE) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but INSM is classified in Biotechnology while PFE is classified in Pharmaceuticals.

Company profile comparison for Insmed (INSM) and Pfizer (PFE)
Profile ItemINSMPFE
NameInsmed IncorporatedPfizer Inc.
Country/RegionUnited StatesUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnologyPharmaceuticals
GICS Sub-IndustryBiotechnologyPharmaceuticals
Market Capitalization25.10 billion USD167.52 billion USD
CurrencyUSDUSD
ExchangeNasdaqNYSE
Listing DateJune 1, 2000June 1, 1972
Security TypeCommon StockCommon Stock

Price Performance

Cumulative Growth

INSM
PFE
GSPC
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Insmed (INSM) vs. Pfizer (PFE), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Insmed (INSM) and Pfizer (PFE). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Insmed (INSM) and Pfizer (PFE). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Insmed (INSM) and Pfizer (PFE)
MetricINSMPFE
Total Return (1Y)-39.17%28.65%
Total Return (3Y, Annualized)70.17%6.41%
Total Return (5Y, Annualized)28.96%-3.98%

Risk Profile

Drawdown History

INSM
PFE
GSPC
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Insmed (INSM) vs. Pfizer (PFE), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Insmed (INSM) and Pfizer (PFE). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for Insmed (INSM) and Pfizer (PFE)
MetricINSMPFE
Volatility (1Y, Annualized)63.09%21.72%
Beta (5Y)0.800.35
Max Drawdown (5Y)-56.54%-58.96%
Avg. Volume (3M)2.76M33.67M

Risk-Adjusted Performance

Risk-Return Positioning

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INSM and PFE are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Insmed (INSM) and Pfizer (PFE)
MetricINSMPFE
Sharpe Ratio (1Y)-0.691.12
Sortino Ratio (1Y)-1.041.73

Profitability

ROE (TTM)

Insmed (INSM) reports a negative ROE of -72.45%; negative ROE can reflect losses or negative shareholders’ equity, so it is harder to read as capital efficiency. Meanwhile Pfizer (PFE) reports 4.47%, ranking against industry peers normally.

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-72.45%

Max
109.18%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
INSM
-72.45%
Min
-167.77%

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.47%

Max
109.18%
Q3
6.23%
PFE
4.47%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Insmed (INSM) vs. Pfizer (PFE): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Insmed (INSM) reports a negative net margin of -39.85%, usually indicating a net loss over the period. Meanwhile Pfizer (PFE) reports 6.34%, ranking against industry peers normally.

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-39.85%

Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
INSM
-39.85%

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

6.34%

Max
18.05%
PFE
6.34%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Insmed (INSM) vs. Pfizer (PFE): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Insmed (INSM) reports a negative operating margin of -15.60%, usually indicating that operating costs exceeded revenue at the operating-income line. Meanwhile Pfizer (PFE) reports 33.38%, ranking against industry peers normally.

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-15.60%

Max
83.12%
Q3
14.77%
Median
0.00%
INSM
-15.60%
Q1
-78.82%
Min
-207.40%

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

33.38%

Max
83.12%
PFE
33.38%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Insmed (INSM) vs. Pfizer (PFE): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Insmed (INSM) and Pfizer (PFE)
MetricINSMPFE
ROE (TTM)-72.45%4.47%
ROA (TTM)-17.25%5.59%
Net Margin (TTM)-39.85%6.34%
Operating Margin (TTM)-15.60%33.38%
Gross Margin (TTM)84.40%74.90%

Growth

Revenue Growth

Insmed (INSM) at 66.73% sits in the top revenue growth quartile, while Pfizer (PFE) at -1.65% is in the bottom quartile, showing a clear gap in revenue momentum.

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Insmed (INSM) vs. Pfizer (PFE): A comparison of their Revenue Growth across different time periods.

EPS Growth

Only one side can be read here: Pfizer (PFE) reports EPS growth of -3.55%, ranked against its industry; Insmed (INSM) has no EPS growth figure this period.

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Insmed (INSM) vs. Pfizer (PFE): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Insmed (INSM) and Pfizer (PFE)
MetricINSMPFE
Revenue Growth (YoY)66.73%-1.65%
Revenue Growth (3Y CAGR)35.20%-14.80%
EPS Growth (YoY)---3.55%
EPS Growth (3Y CAGR)---37.12%

Financial Strength

Current Ratio (MRQ)

Insmed (INSM) at 2.86 keeps current ratio within its industry’s typical mid-range, while Pfizer (PFE) at 1.42 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for PFE.

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.86

Max
25.13
Q3
12.13
Median
5.52
INSM
2.86
Q1
2.47
Min
0.10

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.42

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
PFE
1.42
Min
0.10
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Insmed (INSM) vs. Pfizer (PFE): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Both Insmed (INSM) at 1.01 and Pfizer (PFE) at 0.71 lean more heavily on debt funding than most peers, landing in the higher-leverage quartile of their industries.

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.01

Max
1.42
INSM
1.01
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.71

Max
1.42
PFE
0.71
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
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Insmed (INSM) vs. Pfizer (PFE): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Insmed (INSM) and Pfizer (PFE)
MetricINSMPFE
Current Ratio (MRQ)2.861.42
Debt / Equity (MRQ)1.010.71
Net Debt / EBITDA--1.97

Dividends

Dividend Yield (TTM)

Insmed (INSM) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Pfizer (PFE) reports a yield of 7.30%, ranking against industry peers normally.

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

INSM
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.30%

PFE
7.30%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Insmed (INSM) vs. Pfizer (PFE): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Pfizer (PFE) reports payout ratio above 100% at 245.71%, meaning dividends exceeded current-period earnings; Insmed (INSM) pays no dividend (payout 0.00%).

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

INSM
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

245.71%

PFE
245.71%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Insmed (INSM) vs. Pfizer (PFE): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Insmed (INSM) and Pfizer (PFE)
MetricINSMPFE
Dividend Yield (TTM)0.00%7.30%
Dividend Payout Ratio (TTM)0.00%245.71%

Valuation

P/E Ratio (TTM)

An earnings multiple is available for just one side: Pfizer (PFE) trades at 41.99 times trailing earnings, ranked against its peers, while Insmed (INSM) has no P/E ratio this period.

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

--

Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07
INSM
--

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

41.99

Max
85.34
Q3
43.46
PFE
41.99
Median
26.69
Q1
13.30
Min
0.07
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Insmed (INSM) vs. Pfizer (PFE): INSM does not report P/E ratio, so it has no value marker; PFE is benchmarked against the Pharmaceuticals, Biotechnology & Life Sciences industry group.

P/S Ratio (TTM)

Pfizer (PFE) at 2.63 sits in the cheaper P/S ratio quartile while Insmed (INSM) at 16.52 prices around its industry’s middle — PFE costs less per dollar of sales, though read it alongside growth and margins.

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

16.52

Max
58.18
Q3
25.77
INSM
16.52
Median
7.30
Q1
3.01
Min
0.01

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.63

Max
58.18
Q3
25.77
Median
7.30
Q1
3.01
PFE
2.63
Min
0.01
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Insmed (INSM) vs. Pfizer (PFE): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Pfizer (PFE) at 1.88 sits near its industry’s typical P/B ratio, while Insmed (INSM) at 34.55 prices above its benchmark range — INSM looks rich relative to book.

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

34.55

INSM
34.55
Max
13.53
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59

PFE

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.88

Max
13.53
Q3
6.54
Median
3.25
PFE
1.88
Q1
1.69
Min
-5.59
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Insmed (INSM) vs. Pfizer (PFE): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Insmed (INSM) and Pfizer (PFE)
MetricINSMPFE
P/E Ratio (TTM)--41.99
P/S Ratio (TTM)16.522.63
P/B Ratio (MRQ)34.551.88
Free Cash Flow Yield (TTM)-1.82%7.76%