INCY vs. TAK: Incyte vs. Takeda Pharmaceutical Stock Comparison
How do Incyte (INCY) and Takeda Pharmaceutical (TAK) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.
Company Profile
Incyte (INCY) and Takeda Pharmaceutical (TAK) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but INCY is classified in Biotechnology while TAK is classified in Pharmaceuticals.
Incyte (INCY) trades as ordinary local shares, while Takeda Pharmaceutical (TAK) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.
| Profile Item | INCY | TAK |
|---|---|---|
| Name | Incyte Corp. | Takeda Pharmaceutical Co Ltd ADR |
| Country/Region | United States | Japan |
| GICS Sector | Health Care | Health Care |
| GICS Industry Group | Pharmaceuticals, Biotechnology & Life Sciences | Pharmaceuticals, Biotechnology & Life Sciences |
| GICS Industry | Biotechnology | Pharmaceuticals |
| GICS Sub-Industry | Biotechnology | Pharmaceuticals |
| Market Capitalization | 24.39 billion USD | 67.16 billion USD |
| Currency | USD | USD |
| Exchange | Nasdaq | NYSE |
| Listing Date | November 4, 1993 | January 5, 2010 |
| Security Type | Common Stock | ADR |
Price Performance
Cumulative Growth
Trailing Returns
Calendar-Year Returns
Performance Metrics
| Metric | INCY | TAK |
|---|---|---|
| Total Return (1Y) | 14.06% | 54.54% |
| Total Return (3Y, Annualized) | 32.03% | 18.39% |
| Total Return (5Y, Annualized) | 12.69% | 9.29% |
Risk Profile
Drawdown History
Return Distribution
Risk Metrics
Takeda Pharmaceutical (TAK) reports a negative beta of -0.01, suggesting inverse market sensitivity over the measurement window. That is uncommon for ordinary equities and can reflect commodity-linked or hedge-like exposure, but it can also come from statistical noise. Incyte (INCY) has a non-negative beta of 0.78.
| Metric | INCY | TAK |
|---|---|---|
| Volatility (1Y, Annualized) | 33.19% | 21.45% |
| Beta (5Y) | 0.78 | -0.01 |
| Max Drawdown (5Y) | -40.50% | -24.83% |
| Avg. Volume (3M) | 1.58M | 2.61M |
Risk-Adjusted Performance
Risk-Return Positioning
Risk-Adjusted Metrics
| Metric | INCY | TAK |
|---|---|---|
| Sharpe Ratio (1Y) | 0.29 | 2.34 |
| Sortino Ratio (1Y) | 0.46 | 3.88 |
Profitability
ROE (TTM)
Incyte (INCY) at 7.84% sits in the top ROE quartile, while Takeda Pharmaceutical (TAK) at 0.56% is closer to the peer norm — stronger capital efficiency for INCY.
INCY
Pharmaceuticals, Biotechnology & Life Sciences industry group
7.84%
- Max
- 109.18%
- INCY
- 7.84%
- Q3
- 6.23%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.56%
- Max
- 109.18%
- Q3
- 6.23%
- TAK
- 0.56%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
Net Margin (TTM)
Incyte (INCY) at 6.71% retains a top-quartile share of revenue as profit, ahead of Takeda Pharmaceutical (TAK) at 0.87%, which keeps about the industry-typical share.
INCY
Pharmaceuticals, Biotechnology & Life Sciences industry group
6.71%
- Max
- 18.05%
- INCY
- 6.71%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.87%
- Max
- 18.05%
- Q3
- 4.78%
- TAK
- 0.87%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
Operating Margin (TTM)
Both Incyte (INCY) at 33.72% and Takeda Pharmaceutical (TAK) at 24.55% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.
INCY
Pharmaceuticals, Biotechnology & Life Sciences industry group
33.72%
- Max
- 83.12%
- INCY
- 33.72%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
24.55%
- Max
- 83.12%
- TAK
- 24.55%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
Profitability Metrics
| Metric | INCY | TAK |
|---|---|---|
| ROE (TTM) | 7.84% | 0.56% |
| ROA (TTM) | 17.78% | 3.27% |
| Net Margin (TTM) | 6.71% | 0.87% |
| Operating Margin (TTM) | 33.72% | 24.55% |
| Gross Margin (TTM) | 56.02% | 64.77% |
Growth
Revenue Growth
Incyte (INCY) at 21.22% is around its peer norm for revenue growth, while Takeda Pharmaceutical (TAK) at -1.66% drops into the bottom quartile, signaling weaker demand or pricing momentum.
EPS Growth
Both companies show strong earnings momentum, but Incyte (INCY) at 4,173.33% is the standout with EPS growth above its industry range; Takeda Pharmaceutical (TAK) at 77.96% also sits in the top quartile.
Growth Metrics
| Metric | INCY | TAK |
|---|---|---|
| Revenue Growth (YoY) | 21.22% | -1.66% |
| Revenue Growth (3Y CAGR) | 14.84% | 3.81% |
| EPS Growth (YoY) | 4,173.33% | 77.96% |
| EPS Growth (3Y CAGR) | 61.56% | -16.01% |
Financial Strength
Current Ratio (MRQ)
Incyte (INCY) at 3.84 keeps current ratio within its industry’s typical mid-range, while Takeda Pharmaceutical (TAK) at 1.15 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for TAK.
INCY
Pharmaceuticals, Biotechnology & Life Sciences industry group
3.84
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- INCY
- 3.84
- Q1
- 2.47
- Min
- 0.10
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.15
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- Q1
- 2.47
- TAK
- 1.15
- Min
- 0.10
Debt / Equity (MRQ)
Incyte (INCY) at 0.01 keeps leverage in the lower quartile, while Takeda Pharmaceutical (TAK) at 0.72 sits in the higher-leverage quartile.
INCY
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.01
- Max
- 1.42
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- INCY
- 0.01
- Min
- 0.00
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.72
- Max
- 1.42
- TAK
- 0.72
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
Financial Strength Metrics
| Metric | INCY | TAK |
|---|---|---|
| Current Ratio (MRQ) | 3.84 | 1.15 |
| Debt / Equity (MRQ) | 0.01 | 0.72 |
| Net Debt / EBITDA | -1.88 | 3.61 |
Dividends
Dividend Yield (TTM)
Incyte (INCY) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Takeda Pharmaceutical (TAK) reports a yield of 953.28%, ranking against industry peers normally.
INCY
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- INCY
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
953.28%
- TAK
- 953.28%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Payout Ratio (TTM)
Takeda Pharmaceutical (TAK) reports payout ratio above 100% at 426.53%, meaning dividends exceeded current-period earnings; Incyte (INCY) pays no dividend (payout 0.00%).
INCY
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- INCY
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
426.53%
- TAK
- 426.53%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Metrics
| Metric | INCY | TAK |
|---|---|---|
| Dividend Yield (TTM) | 0.00% | 953.28% |
| Dividend Payout Ratio (TTM) | 0.00% | 426.53% |
Valuation
P/E Ratio (TTM)
Both look expensive on trailing earnings: Incyte (INCY) at 61.05 sits in the richer P/E ratio quartile, and Takeda Pharmaceutical (TAK) at 300.29 is richer still, above its industry range.
INCY
Pharmaceuticals, Biotechnology & Life Sciences industry group
61.05
- Max
- 85.34
- INCY
- 61.05
- Q3
- 43.46
- Median
- 26.69
- Q1
- 13.30
- Min
- 0.07
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
300.29
- TAK
- 300.29
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- Q1
- 13.30
- Min
- 0.07
P/S Ratio (TTM)
Takeda Pharmaceutical (TAK) at 0.01 sits in the cheaper P/S ratio quartile while Incyte (INCY) at 4.06 prices around its industry’s middle — TAK costs less per dollar of sales, though read it alongside growth and margins.
INCY
Pharmaceuticals, Biotechnology & Life Sciences industry group
4.06
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- INCY
- 4.06
- Q1
- 3.01
- Min
- 0.01
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.01
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- Q1
- 3.01
- TAK
- 0.01
- Min
- 0.01
P/B Ratio (MRQ)
Takeda Pharmaceutical (TAK) at 1.43 sits in the lower P/B ratio quartile against book while Incyte (INCY) at 4.33 is valued near its industry’s middle — TAK is cheaper on assets, though weigh it against ROE and asset quality.
INCY
Pharmaceuticals, Biotechnology & Life Sciences industry group
4.33
- Max
- 13.53
- Q3
- 6.54
- INCY
- 4.33
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.43
- Max
- 13.53
- Q3
- 6.54
- Median
- 3.25
- Q1
- 1.69
- TAK
- 1.43
- Min
- -5.59
Valuation Metrics
| Metric | INCY | TAK |
|---|---|---|
| P/E Ratio (TTM) | 61.05 | 300.29 |
| P/S Ratio (TTM) | 4.06 | 0.01 |
| P/B Ratio (MRQ) | 4.33 | 1.43 |
| Free Cash Flow Yield (TTM) | 5.28% | 1,014.61% |