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INCY vs. TAK: Incyte vs. Takeda Pharmaceutical Stock Comparison

How do Incyte (INCY) and Takeda Pharmaceutical (TAK) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Incyte (INCY) and Takeda Pharmaceutical (TAK) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but INCY is classified in Biotechnology while TAK is classified in Pharmaceuticals.

Incyte (INCY) trades as ordinary local shares, while Takeda Pharmaceutical (TAK) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.

Company profile comparison for Incyte (INCY) and Takeda Pharmaceutical (TAK)
Profile ItemINCYTAK
NameIncyte Corp.Takeda Pharmaceutical Co Ltd ADR
Country/RegionUnited StatesJapan
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnologyPharmaceuticals
GICS Sub-IndustryBiotechnologyPharmaceuticals
Market Capitalization24.39 billion USD67.16 billion USD
CurrencyUSDUSD
ExchangeNasdaqNYSE
Listing DateNovember 4, 1993January 5, 2010
Security TypeCommon StockADR

Price Performance

Cumulative Growth

INCY
TAK
GSPC
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Incyte (INCY) and Takeda Pharmaceutical (TAK). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Incyte (INCY) and Takeda Pharmaceutical (TAK). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Incyte (INCY) and Takeda Pharmaceutical (TAK)
MetricINCYTAK
Total Return (1Y)14.06%54.54%
Total Return (3Y, Annualized)32.03%18.39%
Total Return (5Y, Annualized)12.69%9.29%

Risk Profile

Drawdown History

INCY
TAK
GSPC
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Incyte (INCY) and Takeda Pharmaceutical (TAK). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Takeda Pharmaceutical (TAK) reports a negative beta of -0.01, suggesting inverse market sensitivity over the measurement window. That is uncommon for ordinary equities and can reflect commodity-linked or hedge-like exposure, but it can also come from statistical noise. Incyte (INCY) has a non-negative beta of 0.78.

Risk profile metrics for Incyte (INCY) and Takeda Pharmaceutical (TAK)
MetricINCYTAK
Volatility (1Y, Annualized)33.19%21.45%
Beta (5Y)0.78-0.01
Max Drawdown (5Y)-40.50%-24.83%
Avg. Volume (3M)1.58M2.61M

Risk-Adjusted Performance

Risk-Return Positioning

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INCY and TAK are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Incyte (INCY) and Takeda Pharmaceutical (TAK)
MetricINCYTAK
Sharpe Ratio (1Y)0.292.34
Sortino Ratio (1Y)0.463.88

Profitability

ROE (TTM)

Incyte (INCY) at 7.84% sits in the top ROE quartile, while Takeda Pharmaceutical (TAK) at 0.56% is closer to the peer norm — stronger capital efficiency for INCY.

INCY

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.84%

Max
109.18%
INCY
7.84%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.56%

Max
109.18%
Q3
6.23%
TAK
0.56%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Incyte (INCY) at 6.71% retains a top-quartile share of revenue as profit, ahead of Takeda Pharmaceutical (TAK) at 0.87%, which keeps about the industry-typical share.

INCY

Pharmaceuticals, Biotechnology & Life Sciences industry group

6.71%

Max
18.05%
INCY
6.71%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.87%

Max
18.05%
Q3
4.78%
TAK
0.87%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Incyte (INCY) at 33.72% and Takeda Pharmaceutical (TAK) at 24.55% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

INCY

Pharmaceuticals, Biotechnology & Life Sciences industry group

33.72%

Max
83.12%
INCY
33.72%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

24.55%

Max
83.12%
TAK
24.55%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Incyte (INCY) and Takeda Pharmaceutical (TAK)
MetricINCYTAK
ROE (TTM)7.84%0.56%
ROA (TTM)17.78%3.27%
Net Margin (TTM)6.71%0.87%
Operating Margin (TTM)33.72%24.55%
Gross Margin (TTM)56.02%64.77%

Growth

Revenue Growth

Incyte (INCY) at 21.22% is around its peer norm for revenue growth, while Takeda Pharmaceutical (TAK) at -1.66% drops into the bottom quartile, signaling weaker demand or pricing momentum.

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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their Revenue Growth across different time periods.

EPS Growth

Both companies show strong earnings momentum, but Incyte (INCY) at 4,173.33% is the standout with EPS growth above its industry range; Takeda Pharmaceutical (TAK) at 77.96% also sits in the top quartile.

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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Incyte (INCY) and Takeda Pharmaceutical (TAK)
MetricINCYTAK
Revenue Growth (YoY)21.22%-1.66%
Revenue Growth (3Y CAGR)14.84%3.81%
EPS Growth (YoY)4,173.33%77.96%
EPS Growth (3Y CAGR)61.56%-16.01%

Financial Strength

Current Ratio (MRQ)

Incyte (INCY) at 3.84 keeps current ratio within its industry’s typical mid-range, while Takeda Pharmaceutical (TAK) at 1.15 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for TAK.

INCY

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.84

Max
25.13
Q3
12.13
Median
5.52
INCY
3.84
Q1
2.47
Min
0.10

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.15

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
TAK
1.15
Min
0.10
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Incyte (INCY) at 0.01 keeps leverage in the lower quartile, while Takeda Pharmaceutical (TAK) at 0.72 sits in the higher-leverage quartile.

INCY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.01

Max
1.42
Q3
0.65
Median
0.15
Q1
0.02
INCY
0.01
Min
0.00

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.72

Max
1.42
TAK
0.72
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Incyte (INCY) and Takeda Pharmaceutical (TAK)
MetricINCYTAK
Current Ratio (MRQ)3.841.15
Debt / Equity (MRQ)0.010.72
Net Debt / EBITDA-1.883.61

Dividends

Dividend Yield (TTM)

Incyte (INCY) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Takeda Pharmaceutical (TAK) reports a yield of 953.28%, ranking against industry peers normally.

INCY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

INCY
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

953.28%

TAK
953.28%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Takeda Pharmaceutical (TAK) reports payout ratio above 100% at 426.53%, meaning dividends exceeded current-period earnings; Incyte (INCY) pays no dividend (payout 0.00%).

INCY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

INCY
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

426.53%

TAK
426.53%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Incyte (INCY) and Takeda Pharmaceutical (TAK)
MetricINCYTAK
Dividend Yield (TTM)0.00%953.28%
Dividend Payout Ratio (TTM)0.00%426.53%

Valuation

P/E Ratio (TTM)

Both look expensive on trailing earnings: Incyte (INCY) at 61.05 sits in the richer P/E ratio quartile, and Takeda Pharmaceutical (TAK) at 300.29 is richer still, above its industry range.

INCY

Pharmaceuticals, Biotechnology & Life Sciences industry group

61.05

Max
85.34
INCY
61.05
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

300.29

TAK
300.29
Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

Takeda Pharmaceutical (TAK) at 0.01 sits in the cheaper P/S ratio quartile while Incyte (INCY) at 4.06 prices around its industry’s middle — TAK costs less per dollar of sales, though read it alongside growth and margins.

INCY

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.06

Max
58.18
Q3
25.77
Median
7.30
INCY
4.06
Q1
3.01
Min
0.01

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.01

Max
58.18
Q3
25.77
Median
7.30
Q1
3.01
TAK
0.01
Min
0.01
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Takeda Pharmaceutical (TAK) at 1.43 sits in the lower P/B ratio quartile against book while Incyte (INCY) at 4.33 is valued near its industry’s middle — TAK is cheaper on assets, though weigh it against ROE and asset quality.

INCY

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.33

Max
13.53
Q3
6.54
INCY
4.33
Median
3.25
Q1
1.69
Min
-5.59

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.43

Max
13.53
Q3
6.54
Median
3.25
Q1
1.69
TAK
1.43
Min
-5.59
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Incyte (INCY) vs. Takeda Pharmaceutical (TAK): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Incyte (INCY) and Takeda Pharmaceutical (TAK)
MetricINCYTAK
P/E Ratio (TTM)61.05300.29
P/S Ratio (TTM)4.060.01
P/B Ratio (MRQ)4.331.43
Free Cash Flow Yield (TTM)5.28%1,014.61%