ILMN vs. MRK: Illumina vs. Merck Stock Comparison
How do Illumina (ILMN) and Merck (MRK) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.
Company Profile
Illumina (ILMN) and Merck (MRK) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but ILMN is classified in Life Sciences Tools & Services while MRK is classified in Pharmaceuticals.
| Profile Item | ILMN | MRK |
|---|---|---|
| Name | Illumina Inc. | Merck & Co., Inc. |
| Country/Region | United States | United States |
| GICS Sector | Health Care | Health Care |
| GICS Industry Group | Pharmaceuticals, Biotechnology & Life Sciences | Pharmaceuticals, Biotechnology & Life Sciences |
| GICS Industry | Life Sciences Tools & Services | Pharmaceuticals |
| GICS Sub-Industry | Life Sciences Tools & Services | Pharmaceuticals |
| Market Capitalization | 32.23 billion USD | 361.73 billion USD |
| Currency | USD | USD |
| Exchange | Nasdaq | NYSE |
| Listing Date | July 28, 2000 | January 2, 1962 |
| Security Type | Common Stock | Common Stock |
Price Performance
Cumulative Growth
Trailing Returns
Calendar-Year Returns
Performance Metrics
| Metric | ILMN | MRK |
|---|---|---|
| Total Return (1Y) | 79.70% | 76.14% |
| Total Return (3Y, Annualized) | 28.16% | 16.48% |
| Total Return (5Y, Annualized) | -10.65% | 15.77% |
Risk Profile
Drawdown History
Return Distribution
Risk Metrics
Illumina (ILMN) has an aggressive beta of 1.46, indicating higher sensitivity to broad-market moves, while Merck (MRK) is defensive at 0.11 and tends to be less market-sensitive — they sit on opposite ends of the beta spectrum.
| Metric | ILMN | MRK |
|---|---|---|
| Volatility (1Y, Annualized) | 48.47% | 30.24% |
| Beta (5Y) | 1.46 | 0.11 |
| Max Drawdown (5Y) | -82.95% | -43.44% |
| Avg. Volume (3M) | 2.77M | 10.24M |
Risk-Adjusted Performance
Risk-Return Positioning
Risk-Adjusted Metrics
| Metric | ILMN | MRK |
|---|---|---|
| Sharpe Ratio (1Y) | 1.56 | 2.38 |
| Sortino Ratio (1Y) | 2.25 | 4.33 |
Profitability
ROE (TTM)
Illumina (ILMN) at 32.39% sits in the top ROE quartile, while Merck (MRK) at 5.06% is closer to the peer norm — stronger capital efficiency for ILMN.
ILMN
Pharmaceuticals, Biotechnology & Life Sciences industry group
32.39%
- Max
- 109.18%
- ILMN
- 32.39%
- Q3
- 6.23%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
MRK
Pharmaceuticals, Biotechnology & Life Sciences industry group
5.06%
- Max
- 109.18%
- Q3
- 6.23%
- MRK
- 5.06%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
Net Margin (TTM)
Illumina (ILMN) at 19.72% converts revenue to bottom-line profit above its industry’s benchmark range, while Merck (MRK) at 3.64% keeps roughly the typical share for its industry.
ILMN
Pharmaceuticals, Biotechnology & Life Sciences industry group
19.72%
- ILMN
- 19.72%
- Max
- 18.05%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
MRK
Pharmaceuticals, Biotechnology & Life Sciences industry group
3.64%
- Max
- 18.05%
- Q3
- 4.78%
- MRK
- 3.64%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
Operating Margin (TTM)
Both Illumina (ILMN) at 20.02% and Merck (MRK) at 35.22% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.
ILMN
Pharmaceuticals, Biotechnology & Life Sciences industry group
20.02%
- Max
- 83.12%
- ILMN
- 20.02%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
MRK
Pharmaceuticals, Biotechnology & Life Sciences industry group
35.22%
- Max
- 83.12%
- MRK
- 35.22%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
Profitability Metrics
| Metric | ILMN | MRK |
|---|---|---|
| ROE (TTM) | 32.39% | 5.06% |
| ROA (TTM) | 8.32% | 11.29% |
| Net Margin (TTM) | 19.72% | 3.64% |
| Operating Margin (TTM) | 20.02% | 35.22% |
| Gross Margin (TTM) | 67.68% | 75.20% |
Growth
Revenue Growth
Merck (MRK) at 1.31% is around its peer norm for revenue growth, while Illumina (ILMN) at -0.66% drops into the bottom quartile, signaling weaker demand or pricing momentum.
EPS Growth
Only one side can be read here: Merck (MRK) reports EPS growth of 8.01%, ranked against its industry; Illumina (ILMN) has no EPS growth figure this period.
Growth Metrics
| Metric | ILMN | MRK |
|---|---|---|
| Revenue Growth (YoY) | -0.66% | 1.31% |
| Revenue Growth (3Y CAGR) | -1.78% | 3.12% |
| EPS Growth (YoY) | -- | 8.01% |
| EPS Growth (3Y CAGR) | -- | 8.43% |
Financial Strength
Current Ratio (MRQ)
Illumina (ILMN) at 2.63 keeps current ratio within its industry’s typical mid-range, while Merck (MRK) at 1.35 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for MRK.
ILMN
Pharmaceuticals, Biotechnology & Life Sciences industry group
2.63
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- ILMN
- 2.63
- Q1
- 2.47
- Min
- 0.10
MRK
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.35
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- Q1
- 2.47
- MRK
- 1.35
- Min
- 0.10
Debt / Equity (MRQ)
Both Illumina (ILMN) at 0.74 and Merck (MRK) at 1.20 lean more heavily on debt funding than most peers, landing in the higher-leverage quartile of their industries.
ILMN
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.74
- Max
- 1.42
- ILMN
- 0.74
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
MRK
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.20
- Max
- 1.42
- MRK
- 1.20
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
Financial Strength Metrics
| Metric | ILMN | MRK |
|---|---|---|
| Current Ratio (MRQ) | 2.63 | 1.35 |
| Debt / Equity (MRQ) | 0.74 | 1.20 |
| Net Debt / EBITDA | 0.85 | 1.50 |
Dividends
Dividend Yield (TTM)
Illumina (ILMN) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Merck (MRK) reports a yield of 2.29%, ranking against industry peers normally.
ILMN
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- ILMN
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
MRK
Pharmaceuticals, Biotechnology & Life Sciences industry group
2.29%
- MRK
- 2.29%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Payout Ratio (TTM)
Merck (MRK) reports payout ratio above 100% at 343.43%, meaning dividends exceeded current-period earnings; Illumina (ILMN) pays no dividend (payout 0.00%).
ILMN
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- ILMN
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
MRK
Pharmaceuticals, Biotechnology & Life Sciences industry group
343.43%
- MRK
- 343.43%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Metrics
| Metric | ILMN | MRK |
|---|---|---|
| Dividend Yield (TTM) | 0.00% | 2.29% |
| Dividend Payout Ratio (TTM) | 0.00% | 343.43% |
Valuation
P/E Ratio (TTM)
Illumina (ILMN) at 36.68 is near its industry’s usual P/E ratio, while Merck (MRK) at 148.21 sits above its peer range — an unusually expensive price for MRK’s trailing earnings.
ILMN
Pharmaceuticals, Biotechnology & Life Sciences industry group
36.68
- Max
- 85.34
- Q3
- 43.46
- ILMN
- 36.68
- Median
- 26.69
- Q1
- 13.30
- Min
- 0.07
MRK
Pharmaceuticals, Biotechnology & Life Sciences industry group
148.21
- MRK
- 148.21
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- Q1
- 13.30
- Min
- 0.07
P/S Ratio (TTM)
On P/S ratio, both Illumina (ILMN) at 7.10 and Merck (MRK) at 5.37 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.
ILMN
Pharmaceuticals, Biotechnology & Life Sciences industry group
7.10
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- ILMN
- 7.10
- Q1
- 3.01
- Min
- 0.01
MRK
Pharmaceuticals, Biotechnology & Life Sciences industry group
5.37
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- MRK
- 5.37
- Q1
- 3.01
- Min
- 0.01
P/B Ratio (MRQ)
Both Illumina (ILMN) at 10.30 and Merck (MRK) at 8.06 carry a premium to book value versus peers, sitting in the upper P/B ratio quartile of their industries.
ILMN
Pharmaceuticals, Biotechnology & Life Sciences industry group
10.30
- Max
- 13.53
- ILMN
- 10.30
- Q3
- 6.54
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
MRK
Pharmaceuticals, Biotechnology & Life Sciences industry group
8.06
- Max
- 13.53
- MRK
- 8.06
- Q3
- 6.54
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
Valuation Metrics
| Metric | ILMN | MRK |
|---|---|---|
| P/E Ratio (TTM) | 36.68 | 148.21 |
| P/S Ratio (TTM) | 7.10 | 5.37 |
| P/B Ratio (MRQ) | 10.30 | 8.06 |
| Free Cash Flow Yield (TTM) | 2.67% | 3.88% |