HALO vs. TAK: Halozyme Therapeutics vs. Takeda Pharmaceutical Stock Comparison
How do Halozyme Therapeutics (HALO) and Takeda Pharmaceutical (TAK) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.
Company Profile
Halozyme Therapeutics (HALO) and Takeda Pharmaceutical (TAK) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but HALO is classified in Biotechnology while TAK is classified in Pharmaceuticals.
Halozyme Therapeutics (HALO) trades as ordinary local shares, while Takeda Pharmaceutical (TAK) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.
| Profile Item | HALO | TAK |
|---|---|---|
| Name | Halozyme Therapeutics Inc. | Takeda Pharmaceutical Co Ltd ADR |
| Country/Region | United States | Japan |
| GICS Sector | Health Care | Health Care |
| GICS Industry Group | Pharmaceuticals, Biotechnology & Life Sciences | Pharmaceuticals, Biotechnology & Life Sciences |
| GICS Industry | Biotechnology | Pharmaceuticals |
| GICS Sub-Industry | Biotechnology | Pharmaceuticals |
| Market Capitalization | 11.81 billion USD | 67.16 billion USD |
| Currency | USD | USD |
| Exchange | Nasdaq | NYSE |
| Listing Date | March 16, 2004 | January 5, 2010 |
| Security Type | Common Stock | ADR |
Price Performance
Cumulative Growth
Trailing Returns
Calendar-Year Returns
Performance Metrics
| Metric | HALO | TAK |
|---|---|---|
| Total Return (1Y) | 50.94% | 54.54% |
| Total Return (3Y, Annualized) | 41.08% | 18.39% |
| Total Return (5Y, Annualized) | 21.68% | 9.29% |
Risk Profile
Drawdown History
Return Distribution
Risk Metrics
Takeda Pharmaceutical (TAK) reports a negative beta of -0.01, suggesting inverse market sensitivity over the measurement window. That is uncommon for ordinary equities and can reflect commodity-linked or hedge-like exposure, but it can also come from statistical noise. Halozyme Therapeutics (HALO) has a non-negative beta of 0.96.
| Metric | HALO | TAK |
|---|---|---|
| Volatility (1Y, Annualized) | 41.19% | 21.45% |
| Beta (5Y) | 0.96 | -0.01 |
| Max Drawdown (5Y) | -49.06% | -24.83% |
| Avg. Volume (3M) | 2.29M | 2.61M |
Risk-Adjusted Performance
Risk-Return Positioning
Risk-Adjusted Metrics
| Metric | HALO | TAK |
|---|---|---|
| Sharpe Ratio (1Y) | 1.13 | 2.34 |
| Sortino Ratio (1Y) | 1.78 | 3.88 |
Profitability
ROE (TTM)
Halozyme Therapeutics (HALO) at 216.38% clears its industry range for ROE, a sharper capital-efficiency signal than Takeda Pharmaceutical (TAK) at 0.56%, which is closer to a typical peer reading.
HALO
Pharmaceuticals, Biotechnology & Life Sciences industry group
216.38%
- HALO
- 216.38%
- Max
- 109.18%
- Q3
- 6.23%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.56%
- Max
- 109.18%
- Q3
- 6.23%
- TAK
- 0.56%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
Net Margin (TTM)
Halozyme Therapeutics (HALO) at 26.93% converts revenue to bottom-line profit above its industry’s benchmark range, while Takeda Pharmaceutical (TAK) at 0.87% keeps roughly the typical share for its industry.
HALO
Pharmaceuticals, Biotechnology & Life Sciences industry group
26.93%
- HALO
- 26.93%
- Max
- 18.05%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.87%
- Max
- 18.05%
- Q3
- 4.78%
- TAK
- 0.87%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
Operating Margin (TTM)
Both Halozyme Therapeutics (HALO) at 59.84% and Takeda Pharmaceutical (TAK) at 24.55% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.
HALO
Pharmaceuticals, Biotechnology & Life Sciences industry group
59.84%
- Max
- 83.12%
- HALO
- 59.84%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
24.55%
- Max
- 83.12%
- TAK
- 24.55%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
Profitability Metrics
| Metric | HALO | TAK |
|---|---|---|
| ROE (TTM) | 216.38% | 0.56% |
| ROA (TTM) | 22.42% | 3.27% |
| Net Margin (TTM) | 26.93% | 0.87% |
| Operating Margin (TTM) | 59.84% | 24.55% |
| Gross Margin (TTM) | 77.74% | 64.77% |
Growth
Revenue Growth
Halozyme Therapeutics (HALO) at 37.55% is around its peer norm for revenue growth, while Takeda Pharmaceutical (TAK) at -1.66% drops into the bottom quartile, signaling weaker demand or pricing momentum.
EPS Growth
Takeda Pharmaceutical (TAK) at 77.96% sits in the top EPS growth quartile, while Halozyme Therapeutics (HALO) at -25.36% is closer to the peer norm — faster per-share earnings growth for TAK.
Growth Metrics
| Metric | HALO | TAK |
|---|---|---|
| Revenue Growth (YoY) | 37.55% | -1.66% |
| Revenue Growth (3Y CAGR) | 28.38% | 3.81% |
| EPS Growth (YoY) | -25.36% | 77.96% |
| EPS Growth (3Y CAGR) | 21.14% | -16.01% |
Financial Strength
Current Ratio (MRQ)
Halozyme Therapeutics (HALO) at 3.88 keeps current ratio within its industry’s typical mid-range, while Takeda Pharmaceutical (TAK) at 1.15 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for TAK.
HALO
Pharmaceuticals, Biotechnology & Life Sciences industry group
3.88
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- HALO
- 3.88
- Q1
- 2.47
- Min
- 0.10
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.15
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- Q1
- 2.47
- TAK
- 1.15
- Min
- 0.10
Debt / Equity (MRQ)
Only one side’s leverage can be read here: Takeda Pharmaceutical (TAK) carries debt-to-equity ratio of 0.72 against its industry range, while Halozyme Therapeutics (HALO) reports no figure this period.
HALO
Pharmaceuticals, Biotechnology & Life Sciences industry group
--
- Max
- 1.42
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
- HALO
- --
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.72
- Max
- 1.42
- TAK
- 0.72
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
Financial Strength Metrics
| Metric | HALO | TAK |
|---|---|---|
| Current Ratio (MRQ) | 3.88 | 1.15 |
| Debt / Equity (MRQ) | -- | 0.72 |
| Net Debt / EBITDA | 1.90 | 3.61 |
Dividends
Dividend Yield (TTM)
Halozyme Therapeutics (HALO) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Takeda Pharmaceutical (TAK) reports a yield of 953.28%, ranking against industry peers normally.
HALO
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- HALO
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
953.28%
- TAK
- 953.28%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Payout Ratio (TTM)
Takeda Pharmaceutical (TAK) reports payout ratio above 100% at 426.53%, meaning dividends exceeded current-period earnings; Halozyme Therapeutics (HALO) pays no dividend (payout 0.00%).
HALO
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- HALO
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
426.53%
- TAK
- 426.53%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Metrics
| Metric | HALO | TAK |
|---|---|---|
| Dividend Yield (TTM) | 0.00% | 953.28% |
| Dividend Payout Ratio (TTM) | 0.00% | 426.53% |
Valuation
P/E Ratio (TTM)
Halozyme Therapeutics (HALO) at 25.91 is near its industry’s usual P/E ratio, while Takeda Pharmaceutical (TAK) at 300.29 sits above its peer range — an unusually expensive price for TAK’s trailing earnings.
HALO
Pharmaceuticals, Biotechnology & Life Sciences industry group
25.91
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- HALO
- 25.91
- Q1
- 13.30
- Min
- 0.07
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
300.29
- TAK
- 300.29
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- Q1
- 13.30
- Min
- 0.07
P/S Ratio (TTM)
Takeda Pharmaceutical (TAK) at 0.01 sits in the cheaper P/S ratio quartile while Halozyme Therapeutics (HALO) at 6.55 prices around its industry’s middle — TAK costs less per dollar of sales, though read it alongside growth and margins.
HALO
Pharmaceuticals, Biotechnology & Life Sciences industry group
6.55
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- HALO
- 6.55
- Q1
- 3.01
- Min
- 0.01
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.01
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- Q1
- 3.01
- TAK
- 0.01
- Min
- 0.01
P/B Ratio (MRQ)
Halozyme Therapeutics (HALO) reports a negative P/B ratio of -213.67, meaning negative book equity — the multiple itself is not meaningful for valuation. Meanwhile Takeda Pharmaceutical (TAK) reports 1.43, ranking against industry peers normally.
HALO
Pharmaceuticals, Biotechnology & Life Sciences industry group
-213.67
- Max
- 13.53
- Q3
- 6.54
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
- HALO
- -213.67
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.43
- Max
- 13.53
- Q3
- 6.54
- Median
- 3.25
- Q1
- 1.69
- TAK
- 1.43
- Min
- -5.59
Valuation Metrics
| Metric | HALO | TAK |
|---|---|---|
| P/E Ratio (TTM) | 25.91 | 300.29 |
| P/S Ratio (TTM) | 6.55 | 0.01 |
| P/B Ratio (MRQ) | -213.67 | 1.43 |
| Free Cash Flow Yield (TTM) | 3.48% | 1,014.61% |