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HALO vs. ILMN: Halozyme Therapeutics vs. Illumina Stock Comparison

How do Halozyme Therapeutics (HALO) and Illumina (ILMN) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Halozyme Therapeutics (HALO) and Illumina (ILMN) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but HALO is classified in Biotechnology while ILMN is classified in Life Sciences Tools & Services.

Company profile comparison for Halozyme Therapeutics (HALO) and Illumina (ILMN)
Profile ItemHALOILMN
NameHalozyme Therapeutics Inc.Illumina Inc.
Country/RegionUnited StatesUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnologyLife Sciences Tools & Services
GICS Sub-IndustryBiotechnologyLife Sciences Tools & Services
Market Capitalization11.81 billion USD32.23 billion USD
CurrencyUSDUSD
ExchangeNasdaqNasdaq
Listing DateMarch 16, 2004July 28, 2000
Security TypeCommon StockCommon Stock

Price Performance

Cumulative Growth

HALO
ILMN
GSPC
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Halozyme Therapeutics (HALO) and Illumina (ILMN). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Halozyme Therapeutics (HALO) and Illumina (ILMN). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Halozyme Therapeutics (HALO) and Illumina (ILMN)
MetricHALOILMN
Total Return (1Y)50.94%79.70%
Total Return (3Y, Annualized)41.08%28.16%
Total Return (5Y, Annualized)21.68%-10.65%

Risk Profile

Drawdown History

HALO
ILMN
GSPC
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Halozyme Therapeutics (HALO) and Illumina (ILMN). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for Halozyme Therapeutics (HALO) and Illumina (ILMN)
MetricHALOILMN
Volatility (1Y, Annualized)41.19%48.47%
Beta (5Y)0.961.46
Max Drawdown (5Y)-49.06%-82.95%
Avg. Volume (3M)2.29M2.77M

Risk-Adjusted Performance

Risk-Return Positioning

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HALO and ILMN are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Halozyme Therapeutics (HALO) and Illumina (ILMN)
MetricHALOILMN
Sharpe Ratio (1Y)1.131.56
Sortino Ratio (1Y)1.782.25

Profitability

ROE (TTM)

Both companies show strong equity returns, but Halozyme Therapeutics (HALO) at 216.38% is the standout with ROE above its industry range; Illumina (ILMN) at 32.39% also sits in the top quartile.

HALO

Pharmaceuticals, Biotechnology & Life Sciences industry group

216.38%

HALO
216.38%
Max
109.18%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

ILMN

Pharmaceuticals, Biotechnology & Life Sciences industry group

32.39%

Max
109.18%
ILMN
32.39%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Both Halozyme Therapeutics (HALO) at 26.93% and Illumina (ILMN) at 19.72% keep an unusually large share of revenue as bottom-line profit — each net margin clears its industry’s benchmark range.

HALO

Pharmaceuticals, Biotechnology & Life Sciences industry group

26.93%

HALO
26.93%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%

ILMN

Pharmaceuticals, Biotechnology & Life Sciences industry group

19.72%

ILMN
19.72%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Halozyme Therapeutics (HALO) at 59.84% and Illumina (ILMN) at 20.02% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

HALO

Pharmaceuticals, Biotechnology & Life Sciences industry group

59.84%

Max
83.12%
HALO
59.84%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

ILMN

Pharmaceuticals, Biotechnology & Life Sciences industry group

20.02%

Max
83.12%
ILMN
20.02%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Halozyme Therapeutics (HALO) and Illumina (ILMN)
MetricHALOILMN
ROE (TTM)216.38%32.39%
ROA (TTM)22.42%8.32%
Net Margin (TTM)26.93%19.72%
Operating Margin (TTM)59.84%20.02%
Gross Margin (TTM)77.74%67.68%

Growth

Revenue Growth

Halozyme Therapeutics (HALO) at 37.55% is around its peer norm for revenue growth, while Illumina (ILMN) at -0.66% drops into the bottom quartile, signaling weaker demand or pricing momentum.

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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): A comparison of their Revenue Growth across different time periods.

EPS Growth

Only one side can be read here: Halozyme Therapeutics (HALO) reports EPS growth of -25.36%, ranked against its industry; Illumina (ILMN) has no EPS growth figure this period.

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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Halozyme Therapeutics (HALO) and Illumina (ILMN)
MetricHALOILMN
Revenue Growth (YoY)37.55%-0.66%
Revenue Growth (3Y CAGR)28.38%-1.78%
EPS Growth (YoY)-25.36%--
EPS Growth (3Y CAGR)21.14%--

Financial Strength

Current Ratio (MRQ)

Both Halozyme Therapeutics (HALO) at 3.88 and Illumina (ILMN) at 2.63 carry current ratio within their industries’ typical mid-ranges, suggesting balanced short-term liquidity relative to peers.

HALO

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.88

Max
25.13
Q3
12.13
Median
5.52
HALO
3.88
Q1
2.47
Min
0.10

ILMN

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.63

Max
25.13
Q3
12.13
Median
5.52
ILMN
2.63
Q1
2.47
Min
0.10
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Only one side’s leverage can be read here: Illumina (ILMN) carries debt-to-equity ratio of 0.74 against its industry range, while Halozyme Therapeutics (HALO) reports no figure this period.

HALO

Pharmaceuticals, Biotechnology & Life Sciences industry group

--

Max
1.42
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
HALO
--

ILMN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.74

Max
1.42
ILMN
0.74
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): HALO does not report debt-to-equity ratio, so it has no value marker; ILMN is benchmarked against the Pharmaceuticals, Biotechnology & Life Sciences industry group.

Financial Strength Metrics

Financial strength metrics for Halozyme Therapeutics (HALO) and Illumina (ILMN)
MetricHALOILMN
Current Ratio (MRQ)3.882.63
Debt / Equity (MRQ)--0.74
Net Debt / EBITDA1.900.85

Dividends

Dividend Yield (TTM)

Neither Halozyme Therapeutics (HALO) nor Illumina (ILMN) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

HALO

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

HALO
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

ILMN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ILMN
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Neither Halozyme Therapeutics (HALO) nor Illumina (ILMN) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

HALO

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

HALO
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

ILMN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ILMN
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Halozyme Therapeutics (HALO) and Illumina (ILMN)
MetricHALOILMN
Dividend Yield (TTM)0.00%0.00%
Dividend Payout Ratio (TTM)0.00%0.00%

Valuation

P/E Ratio (TTM)

Both Halozyme Therapeutics (HALO) at 25.91 and Illumina (ILMN) at 36.68 land around their industries’ usual P/E ratio levels — neither is getting a clear earnings-multiple discount or premium versus peers.

HALO

Pharmaceuticals, Biotechnology & Life Sciences industry group

25.91

Max
85.34
Q3
43.46
Median
26.69
HALO
25.91
Q1
13.30
Min
0.07

ILMN

Pharmaceuticals, Biotechnology & Life Sciences industry group

36.68

Max
85.34
Q3
43.46
ILMN
36.68
Median
26.69
Q1
13.30
Min
0.07
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

On P/S ratio, both Halozyme Therapeutics (HALO) at 6.55 and Illumina (ILMN) at 7.10 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.

HALO

Pharmaceuticals, Biotechnology & Life Sciences industry group

6.55

Max
58.18
Q3
25.77
Median
7.30
HALO
6.55
Q1
3.01
Min
0.01

ILMN

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.10

Max
58.18
Q3
25.77
Median
7.30
ILMN
7.10
Q1
3.01
Min
0.01
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Halozyme Therapeutics (HALO) reports a negative P/B ratio of -213.67, meaning negative book equity — the multiple itself is not meaningful for valuation. Meanwhile Illumina (ILMN) reports 10.30, ranking against industry peers normally.

HALO

Pharmaceuticals, Biotechnology & Life Sciences industry group

-213.67

Max
13.53
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59
HALO
-213.67

ILMN

Pharmaceuticals, Biotechnology & Life Sciences industry group

10.30

Max
13.53
ILMN
10.30
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59
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Halozyme Therapeutics (HALO) vs. Illumina (ILMN): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Halozyme Therapeutics (HALO) and Illumina (ILMN)
MetricHALOILMN
P/E Ratio (TTM)25.9136.68
P/S Ratio (TTM)6.557.10
P/B Ratio (MRQ)-213.6710.30
Free Cash Flow Yield (TTM)3.48%2.67%