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CRL vs. UTHR: Charles River Laboratories vs. United Therapeutics Stock Comparison

How do Charles River Laboratories (CRL) and United Therapeutics (UTHR) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Charles River Laboratories (CRL) and United Therapeutics (UTHR) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but CRL is classified in Life Sciences Tools & Services while UTHR is classified in Biotechnology.

Company profile comparison for Charles River Laboratories (CRL) and United Therapeutics (UTHR)
Profile ItemCRLUTHR
NameCharles River Laboratories International, Inc.United Therapeutics Corporation
Country/RegionUnited StatesUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryLife Sciences Tools & ServicesBiotechnology
GICS Sub-IndustryLife Sciences Tools & ServicesBiotechnology
Market Capitalization16.17 billion USD23.94 billion USD
CurrencyUSDUSD
ExchangeNYSENasdaq
Listing DateJune 23, 2000June 17, 1999
Security TypeCommon StockCommon Stock

Price Performance

Cumulative Growth

CRL
UTHR
GSPC
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Charles River Laboratories (CRL) and United Therapeutics (UTHR). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Charles River Laboratories (CRL) and United Therapeutics (UTHR). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Charles River Laboratories (CRL) and United Therapeutics (UTHR)
MetricCRLUTHR
Total Return (1Y)110.83%28.77%
Total Return (3Y, Annualized)27.87%37.63%
Total Return (5Y, Annualized)-1.57%23.78%

Risk Profile

Drawdown History

CRL
UTHR
GSPC
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Charles River Laboratories (CRL) and United Therapeutics (UTHR). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Charles River Laboratories (CRL) has an aggressive beta of 1.33, indicating higher sensitivity to broad-market moves, while United Therapeutics (UTHR) is defensive at 0.49 and tends to be less market-sensitive — they sit on opposite ends of the beta spectrum.

Risk profile metrics for Charles River Laboratories (CRL) and United Therapeutics (UTHR)
MetricCRLUTHR
Volatility (1Y, Annualized)47.81%35.00%
Beta (5Y)1.330.49
Max Drawdown (5Y)-74.73%-33.00%
Avg. Volume (3M)1.05M694.55K

Risk-Adjusted Performance

Risk-Return Positioning

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CRL and UTHR are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Charles River Laboratories (CRL) and United Therapeutics (UTHR)
MetricCRLUTHR
Sharpe Ratio (1Y)2.230.70
Sortino Ratio (1Y)3.581.29

Profitability

ROE (TTM)

United Therapeutics (UTHR) at 19.13% sits in the top ROE quartile, while Charles River Laboratories (CRL) at 1.27% is closer to the peer norm — stronger capital efficiency for UTHR.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.27%

Max
109.18%
Q3
6.23%
CRL
1.27%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

UTHR

Pharmaceuticals, Biotechnology & Life Sciences industry group

19.13%

Max
109.18%
UTHR
19.13%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

United Therapeutics (UTHR) at 38.61% converts revenue to bottom-line profit above its industry’s benchmark range, while Charles River Laboratories (CRL) at 1.01% keeps roughly the typical share for its industry.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.01%

Max
18.05%
Q3
4.78%
CRL
1.01%
Median
0.00%
Q1
-4.14%
Min
-17.05%

UTHR

Pharmaceuticals, Biotechnology & Life Sciences industry group

38.61%

UTHR
38.61%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Charles River Laboratories (CRL) at 23.42% and United Therapeutics (UTHR) at 28.99% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

23.42%

Max
83.12%
CRL
23.42%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

UTHR

Pharmaceuticals, Biotechnology & Life Sciences industry group

28.99%

Max
83.12%
UTHR
28.99%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Charles River Laboratories (CRL) and United Therapeutics (UTHR)
MetricCRLUTHR
ROE (TTM)1.27%19.13%
ROA (TTM)4.74%10.91%
Net Margin (TTM)1.01%38.61%
Operating Margin (TTM)23.42%28.99%
Gross Margin (TTM)35.10%86.34%

Growth

Revenue Growth

United Therapeutics (UTHR) at 10.61% is around its peer norm for revenue growth, while Charles River Laboratories (CRL) at -0.85% drops into the bottom quartile, signaling weaker demand or pricing momentum.

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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): A comparison of their Revenue Growth across different time periods.

EPS Growth

United Therapeutics (UTHR) at 13.07% is around its peer norm for EPS growth, while Charles River Laboratories (CRL) at -1,555.00% falls below its industry range, a notably weak earnings reading.

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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Charles River Laboratories (CRL) and United Therapeutics (UTHR)
MetricCRLUTHR
Revenue Growth (YoY)-0.85%10.61%
Revenue Growth (3Y CAGR)0.33%18.02%
EPS Growth (YoY)-1,555.00%13.07%
EPS Growth (3Y CAGR)--22.92%

Financial Strength

Current Ratio (MRQ)

United Therapeutics (UTHR) at 4.61 keeps current ratio within its industry’s typical mid-range, while Charles River Laboratories (CRL) at 1.41 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for CRL.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.41

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
CRL
1.41
Min
0.10

UTHR

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.61

Max
25.13
Q3
12.13
Median
5.52
UTHR
4.61
Q1
2.47
Min
0.10
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Only one side’s leverage can be read here: Charles River Laboratories (CRL) carries debt-to-equity ratio of 0.87 against its industry range, while United Therapeutics (UTHR) reports no figure this period.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.87

Max
1.42
CRL
0.87
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00

UTHR

Pharmaceuticals, Biotechnology & Life Sciences industry group

--

Max
1.42
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
UTHR
--
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): UTHR does not report debt-to-equity ratio, so it has no value marker; CRL is benchmarked against the Pharmaceuticals, Biotechnology & Life Sciences industry group.

Financial Strength Metrics

Financial strength metrics for Charles River Laboratories (CRL) and United Therapeutics (UTHR)
MetricCRLUTHR
Current Ratio (MRQ)1.414.61
Debt / Equity (MRQ)0.87--
Net Debt / EBITDA2.92-1.53

Dividends

Dividend Yield (TTM)

Neither Charles River Laboratories (CRL) nor United Therapeutics (UTHR) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

CRL
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

UTHR

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

UTHR
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Neither Charles River Laboratories (CRL) nor United Therapeutics (UTHR) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

CRL
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

UTHR

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

UTHR
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Charles River Laboratories (CRL) and United Therapeutics (UTHR)
MetricCRLUTHR
Dividend Yield (TTM)0.00%0.00%
Dividend Payout Ratio (TTM)0.00%0.00%

Valuation

P/E Ratio (TTM)

United Therapeutics (UTHR) at 21.22 is near its industry’s usual P/E ratio, while Charles River Laboratories (CRL) at 366.87 sits above its peer range — an unusually expensive price for CRL’s trailing earnings.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

366.87

CRL
366.87
Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07

UTHR

Pharmaceuticals, Biotechnology & Life Sciences industry group

21.22

Max
85.34
Q3
43.46
Median
26.69
UTHR
21.22
Q1
13.30
Min
0.07
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

On P/S ratio, both Charles River Laboratories (CRL) at 4.07 and United Therapeutics (UTHR) at 7.51 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.07

Max
58.18
Q3
25.77
Median
7.30
CRL
4.07
Q1
3.01
Min
0.01

UTHR

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.51

Max
58.18
Q3
25.77
UTHR
7.51
Median
7.30
Q1
3.01
Min
0.01
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

On P/B ratio, both Charles River Laboratories (CRL) at 5.01 and United Therapeutics (UTHR) at 3.80 are valued close to their industries’ norm against book — neither stands out from peers.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.01

Max
13.53
Q3
6.54
CRL
5.01
Median
3.25
Q1
1.69
Min
-5.59

UTHR

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.80

Max
13.53
Q3
6.54
UTHR
3.80
Median
3.25
Q1
1.69
Min
-5.59
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Charles River Laboratories (CRL) vs. United Therapeutics (UTHR): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Charles River Laboratories (CRL) and United Therapeutics (UTHR)
MetricCRLUTHR
P/E Ratio (TTM)366.8721.22
P/S Ratio (TTM)4.077.51
P/B Ratio (MRQ)5.013.80
Free Cash Flow Yield (TTM)2.74%1.90%