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CRL vs. REGN: Charles River Laboratories vs. Regeneron Pharmaceuticals Stock Comparison

How do Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but CRL is classified in Life Sciences Tools & Services while REGN is classified in Biotechnology.

Company profile comparison for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN)
Profile ItemCRLREGN
NameCharles River Laboratories International, Inc.Regeneron Pharmaceuticals, Inc.
Country/RegionUnited StatesUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryLife Sciences Tools & ServicesBiotechnology
GICS Sub-IndustryLife Sciences Tools & ServicesBiotechnology
Market Capitalization16.17 billion USD93.55 billion USD
CurrencyUSDUSD
ExchangeNYSENasdaq
Listing DateJune 23, 2000April 2, 1991
Security TypeCommon StockCommon Stock

Price Performance

Cumulative Growth

CRL
REGN
GSPC
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN)
MetricCRLREGN
Total Return (1Y)110.83%40.87%
Total Return (3Y, Annualized)27.87%5.15%
Total Return (5Y, Annualized)-1.57%8.58%

Risk Profile

Drawdown History

CRL
REGN
GSPC
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Charles River Laboratories (CRL) has an aggressive beta of 1.33, indicating higher sensitivity to broad-market moves, while Regeneron Pharmaceuticals (REGN) is defensive at 0.10 and tends to be less market-sensitive — they sit on opposite ends of the beta spectrum.

Risk profile metrics for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN)
MetricCRLREGN
Volatility (1Y, Annualized)47.81%34.08%
Beta (5Y)1.330.10
Max Drawdown (5Y)-74.73%-59.69%
Avg. Volume (3M)1.05M772.95K

Risk-Adjusted Performance

Risk-Return Positioning

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CRL and REGN are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN)
MetricCRLREGN
Sharpe Ratio (1Y)2.231.07
Sortino Ratio (1Y)3.581.70

Profitability

ROE (TTM)

Regeneron Pharmaceuticals (REGN) at 14.95% sits in the top ROE quartile, while Charles River Laboratories (CRL) at 1.27% is closer to the peer norm — stronger capital efficiency for REGN.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.27%

Max
109.18%
Q3
6.23%
CRL
1.27%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

14.95%

Max
109.18%
REGN
14.95%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Regeneron Pharmaceuticals (REGN) at 28.51% converts revenue to bottom-line profit above its industry’s benchmark range, while Charles River Laboratories (CRL) at 1.01% keeps roughly the typical share for its industry.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.01%

Max
18.05%
Q3
4.78%
CRL
1.01%
Median
0.00%
Q1
-4.14%
Min
-17.05%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

28.51%

REGN
28.51%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Charles River Laboratories (CRL) at 23.42% and Regeneron Pharmaceuticals (REGN) at 40.46% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

23.42%

Max
83.12%
CRL
23.42%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

40.46%

Max
83.12%
REGN
40.46%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN)
MetricCRLREGN
ROE (TTM)1.27%14.95%
ROA (TTM)4.74%7.59%
Net Margin (TTM)1.01%28.51%
Operating Margin (TTM)23.42%40.46%
Gross Margin (TTM)35.10%46.73%

Growth

Revenue Growth

Regeneron Pharmaceuticals (REGN) at 0.99% is around its peer norm for revenue growth, while Charles River Laboratories (CRL) at -0.85% drops into the bottom quartile, signaling weaker demand or pricing momentum.

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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their Revenue Growth across different time periods.

EPS Growth

Regeneron Pharmaceuticals (REGN) at 8.19% is around its peer norm for EPS growth, while Charles River Laboratories (CRL) at -1,555.00% falls below its industry range, a notably weak earnings reading.

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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN)
MetricCRLREGN
Revenue Growth (YoY)-0.85%0.99%
Revenue Growth (3Y CAGR)0.33%5.62%
EPS Growth (YoY)-1,555.00%8.19%
EPS Growth (3Y CAGR)--2.77%

Financial Strength

Current Ratio (MRQ)

Regeneron Pharmaceuticals (REGN) at 3.35 keeps current ratio within its industry’s typical mid-range, while Charles River Laboratories (CRL) at 1.41 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for CRL.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.41

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
CRL
1.41
Min
0.10

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.35

Max
25.13
Q3
12.13
Median
5.52
REGN
3.35
Q1
2.47
Min
0.10
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Regeneron Pharmaceuticals (REGN) at 0.08 carries an industry-typical debt-to-equity mix, while Charles River Laboratories (CRL) at 0.87 uses more debt funding than most peers.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.87

Max
1.42
CRL
0.87
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.08

Max
1.42
Q3
0.65
Median
0.15
REGN
0.08
Q1
0.02
Min
0.00
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN)
MetricCRLREGN
Current Ratio (MRQ)1.413.35
Debt / Equity (MRQ)0.870.08
Net Debt / EBITDA2.92-1.17

Dividends

Dividend Yield (TTM)

Charles River Laboratories (CRL) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Regeneron Pharmaceuticals (REGN) reports a yield of 0.41%, ranking against industry peers normally.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

CRL
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.41%

REGN
0.41%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Charles River Laboratories (CRL) pays no dividend (payout 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Regeneron Pharmaceuticals (REGN) reports a payout of 8.18%, ranking against industry peers normally.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

CRL
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

8.18%

REGN
8.18%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN)
MetricCRLREGN
Dividend Yield (TTM)0.00%0.41%
Dividend Payout Ratio (TTM)0.00%8.18%

Valuation

P/E Ratio (TTM)

Regeneron Pharmaceuticals (REGN) at 19.99 is near its industry’s usual P/E ratio, while Charles River Laboratories (CRL) at 366.87 sits above its peer range — an unusually expensive price for CRL’s trailing earnings.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

366.87

CRL
366.87
Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

19.99

Max
85.34
Q3
43.46
Median
26.69
REGN
19.99
Q1
13.30
Min
0.07
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

On P/S ratio, both Charles River Laboratories (CRL) at 4.07 and Regeneron Pharmaceuticals (REGN) at 5.54 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.07

Max
58.18
Q3
25.77
Median
7.30
CRL
4.07
Q1
3.01
Min
0.01

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.54

Max
58.18
Q3
25.77
Median
7.30
REGN
5.54
Q1
3.01
Min
0.01
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

On P/B ratio, both Charles River Laboratories (CRL) at 5.01 and Regeneron Pharmaceuticals (REGN) at 2.71 are valued close to their industries’ norm against book — neither stands out from peers.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.01

Max
13.53
Q3
6.54
CRL
5.01
Median
3.25
Q1
1.69
Min
-5.59

REGN

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.71

Max
13.53
Q3
6.54
Median
3.25
REGN
2.71
Q1
1.69
Min
-5.59
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Charles River Laboratories (CRL) vs. Regeneron Pharmaceuticals (REGN): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Charles River Laboratories (CRL) and Regeneron Pharmaceuticals (REGN)
MetricCRLREGN
P/E Ratio (TTM)366.8719.99
P/S Ratio (TTM)4.075.54
P/B Ratio (MRQ)5.012.71
Free Cash Flow Yield (TTM)2.74%2.76%