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CRL vs. INSM: Charles River Laboratories vs. Insmed Stock Comparison

How do Charles River Laboratories (CRL) and Insmed (INSM) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Charles River Laboratories (CRL) and Insmed (INSM) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but CRL is classified in Life Sciences Tools & Services while INSM is classified in Biotechnology.

Company profile comparison for Charles River Laboratories (CRL) and Insmed (INSM)
Profile ItemCRLINSM
NameCharles River Laboratories International, Inc.Insmed Incorporated
Country/RegionUnited StatesUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryLife Sciences Tools & ServicesBiotechnology
GICS Sub-IndustryLife Sciences Tools & ServicesBiotechnology
Market Capitalization16.17 billion USD25.10 billion USD
CurrencyUSDUSD
ExchangeNYSENasdaq
Listing DateJune 23, 2000June 1, 2000
Security TypeCommon StockCommon Stock

Price Performance

Cumulative Growth

CRL
INSM
GSPC
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Charles River Laboratories (CRL) vs. Insmed (INSM), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Charles River Laboratories (CRL) and Insmed (INSM). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Charles River Laboratories (CRL) and Insmed (INSM). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Charles River Laboratories (CRL) and Insmed (INSM)
MetricCRLINSM
Total Return (1Y)110.83%-39.17%
Total Return (3Y, Annualized)27.87%70.17%
Total Return (5Y, Annualized)-1.57%28.96%

Risk Profile

Drawdown History

CRL
INSM
GSPC
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Charles River Laboratories (CRL) vs. Insmed (INSM), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Charles River Laboratories (CRL) and Insmed (INSM). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for Charles River Laboratories (CRL) and Insmed (INSM)
MetricCRLINSM
Volatility (1Y, Annualized)47.81%63.09%
Beta (5Y)1.330.80
Max Drawdown (5Y)-74.73%-56.54%
Avg. Volume (3M)1.05M2.76M

Risk-Adjusted Performance

Risk-Return Positioning

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CRL and INSM are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Charles River Laboratories (CRL) and Insmed (INSM)
MetricCRLINSM
Sharpe Ratio (1Y)2.23-0.69
Sortino Ratio (1Y)3.58-1.04

Profitability

ROE (TTM)

Insmed (INSM) reports a negative ROE of -72.45%; negative ROE can reflect losses or negative shareholders’ equity, so it is harder to read as capital efficiency. Meanwhile Charles River Laboratories (CRL) reports 1.27%, ranking against industry peers normally.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.27%

Max
109.18%
Q3
6.23%
CRL
1.27%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-72.45%

Max
109.18%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
INSM
-72.45%
Min
-167.77%
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Charles River Laboratories (CRL) vs. Insmed (INSM): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Insmed (INSM) reports a negative net margin of -39.85%, usually indicating a net loss over the period. Meanwhile Charles River Laboratories (CRL) reports 1.01%, ranking against industry peers normally.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.01%

Max
18.05%
Q3
4.78%
CRL
1.01%
Median
0.00%
Q1
-4.14%
Min
-17.05%

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-39.85%

Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
INSM
-39.85%
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Charles River Laboratories (CRL) vs. Insmed (INSM): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Insmed (INSM) reports a negative operating margin of -15.60%, usually indicating that operating costs exceeded revenue at the operating-income line. Meanwhile Charles River Laboratories (CRL) reports 23.42%, ranking against industry peers normally.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

23.42%

Max
83.12%
CRL
23.42%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

-15.60%

Max
83.12%
Q3
14.77%
Median
0.00%
INSM
-15.60%
Q1
-78.82%
Min
-207.40%
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Charles River Laboratories (CRL) vs. Insmed (INSM): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Charles River Laboratories (CRL) and Insmed (INSM)
MetricCRLINSM
ROE (TTM)1.27%-72.45%
ROA (TTM)4.74%-17.25%
Net Margin (TTM)1.01%-39.85%
Operating Margin (TTM)23.42%-15.60%
Gross Margin (TTM)35.10%84.40%

Growth

Revenue Growth

Insmed (INSM) at 66.73% sits in the top revenue growth quartile, while Charles River Laboratories (CRL) at -0.85% is in the bottom quartile, showing a clear gap in revenue momentum.

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Charles River Laboratories (CRL) vs. Insmed (INSM): A comparison of their Revenue Growth across different time periods.

EPS Growth

Only one side can be read here: Charles River Laboratories (CRL) reports EPS growth of -1,555.00%, ranked against its industry; Insmed (INSM) has no EPS growth figure this period.

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Charles River Laboratories (CRL) vs. Insmed (INSM): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Charles River Laboratories (CRL) and Insmed (INSM)
MetricCRLINSM
Revenue Growth (YoY)-0.85%66.73%
Revenue Growth (3Y CAGR)0.33%35.20%
EPS Growth (YoY)-1,555.00%--
EPS Growth (3Y CAGR)----

Financial Strength

Current Ratio (MRQ)

Insmed (INSM) at 2.86 keeps current ratio within its industry’s typical mid-range, while Charles River Laboratories (CRL) at 1.41 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for CRL.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.41

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
CRL
1.41
Min
0.10

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.86

Max
25.13
Q3
12.13
Median
5.52
INSM
2.86
Q1
2.47
Min
0.10
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Charles River Laboratories (CRL) vs. Insmed (INSM): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Both Charles River Laboratories (CRL) at 0.87 and Insmed (INSM) at 1.01 lean more heavily on debt funding than most peers, landing in the higher-leverage quartile of their industries.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.87

Max
1.42
CRL
0.87
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.01

Max
1.42
INSM
1.01
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
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Charles River Laboratories (CRL) vs. Insmed (INSM): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Charles River Laboratories (CRL) and Insmed (INSM)
MetricCRLINSM
Current Ratio (MRQ)1.412.86
Debt / Equity (MRQ)0.871.01
Net Debt / EBITDA2.92--

Dividends

Dividend Yield (TTM)

Neither Charles River Laboratories (CRL) nor Insmed (INSM) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

CRL
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

INSM
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Charles River Laboratories (CRL) vs. Insmed (INSM): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Neither Charles River Laboratories (CRL) nor Insmed (INSM) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

CRL
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

INSM
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Charles River Laboratories (CRL) vs. Insmed (INSM): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Charles River Laboratories (CRL) and Insmed (INSM)
MetricCRLINSM
Dividend Yield (TTM)0.00%0.00%
Dividend Payout Ratio (TTM)0.00%0.00%

Valuation

P/E Ratio (TTM)

An earnings multiple is available for just one side: Charles River Laboratories (CRL) trades at 366.87 times trailing earnings, ranked against its peers, while Insmed (INSM) has no P/E ratio this period.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

366.87

CRL
366.87
Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

--

Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07
INSM
--
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Charles River Laboratories (CRL) vs. Insmed (INSM): INSM does not report P/E ratio, so it has no value marker; CRL is benchmarked against the Pharmaceuticals, Biotechnology & Life Sciences industry group.

P/S Ratio (TTM)

On P/S ratio, both Charles River Laboratories (CRL) at 4.07 and Insmed (INSM) at 16.52 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.07

Max
58.18
Q3
25.77
Median
7.30
CRL
4.07
Q1
3.01
Min
0.01

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

16.52

Max
58.18
Q3
25.77
INSM
16.52
Median
7.30
Q1
3.01
Min
0.01
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Charles River Laboratories (CRL) vs. Insmed (INSM): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Charles River Laboratories (CRL) at 5.01 sits near its industry’s typical P/B ratio, while Insmed (INSM) at 34.55 prices above its benchmark range — INSM looks rich relative to book.

CRL

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.01

Max
13.53
Q3
6.54
CRL
5.01
Median
3.25
Q1
1.69
Min
-5.59

INSM

Pharmaceuticals, Biotechnology & Life Sciences industry group

34.55

INSM
34.55
Max
13.53
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59
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Charles River Laboratories (CRL) vs. Insmed (INSM): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Charles River Laboratories (CRL) and Insmed (INSM)
MetricCRLINSM
P/E Ratio (TTM)366.87--
P/S Ratio (TTM)4.0716.52
P/B Ratio (MRQ)5.0134.55
Free Cash Flow Yield (TTM)2.74%-1.82%