BNTX vs. RVMD: BioNTech vs. Revolution Medicines Stock Comparison

November 11, 2026

How do BioNTech (BNTX) and Revolution Medicines (RVMD) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

BioNTech (BNTX) and Revolution Medicines (RVMD) are both classified in the Biotechnology sub-industry within the broader Biotechnology industry, placing them in the closest GICS peer bucket.

Revolution Medicines (RVMD) trades as ordinary local shares, while BioNTech (BNTX) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.

Company profile comparison for BioNTech (BNTX) and Revolution Medicines (RVMD)
Profile Item	BNTX	RVMD
Name	BioNTech SE American Depositary Share	Revolution Medicines, Inc.
Country/Region	Germany	United States
GICS Sector	Health Care	Health Care
GICS Industry Group	Pharmaceuticals, Biotechnology & Life Sciences	Pharmaceuticals, Biotechnology & Life Sciences
GICS Industry	Biotechnology	Biotechnology
GICS Sub-Industry	Biotechnology	Biotechnology
Market Capitalization	21.70 billion USD	41.59 billion USD
Currency	USD	USD
Exchange	Nasdaq	Nasdaq
Listing Date	October 10, 2019	February 13, 2020
Security Type	ADR	Common Stock

Price Performance

Cumulative Growth

BNTX

RVMD

GSPC

BioNTech (BNTX) vs. Revolution Medicines (RVMD), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for BioNTech (BNTX) and Revolution Medicines (RVMD). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for BioNTech (BNTX) and Revolution Medicines (RVMD). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for BioNTech (BNTX) and Revolution Medicines (RVMD)
Metric	BNTX	RVMD
Total Return (1Y)	-14.78%	224.80%
Total Return (3Y, Annualized)	-3.99%	114.71%
Total Return (5Y, Annualized)	-17.02%	43.47%

Risk Profile

Drawdown History

BNTX

RVMD

GSPC

BioNTech (BNTX) vs. Revolution Medicines (RVMD), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for BioNTech (BNTX) and Revolution Medicines (RVMD). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for BioNTech (BNTX) and Revolution Medicines (RVMD)
Metric	BNTX	RVMD
Volatility (1Y, Annualized)	47.44%	68.29%
Beta (5Y)	1.30	1.42
Max Drawdown (5Y)	-78.10%	-55.71%
Avg. Volume (3M)	1.21M	2.06M

Risk-Adjusted Performance

Risk-Return Positioning

BNTX and RVMD are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for BioNTech (BNTX) and Revolution Medicines (RVMD)
Metric	BNTX	RVMD
Sharpe Ratio (1Y)	-0.40	3.23
Sortino Ratio (1Y)	-0.59	6.92

Profitability

ROE (TTM)

Both BioNTech (BNTX) at -8.14% and Revolution Medicines (RVMD) at -93.56% report negative ROE values. Negative ROE can reflect losses or negative shareholders’ equity, so both readings need extra context.

BNTX

Pharmaceuticals, Biotechnology & Life Sciences industry group

-8.14%

Max: 109.18%
Q3: 6.23%
BNTX: -8.14%
Median: -26.66%
Q1: -64.05%
Min: -167.77%

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

-93.56%

Max: 109.18%
Q3: 6.23%
Median: -26.66%
Q1: -64.05%
RVMD: -93.56%
Min: -167.77%

BioNTech (BNTX) vs. Revolution Medicines (RVMD): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

BioNTech (BNTX) reports a negative net margin of -60.87%, usually indicating a net loss over the period. Meanwhile Revolution Medicines (RVMD) reports 0.00%, ranking against industry peers normally.

BNTX

Pharmaceuticals, Biotechnology & Life Sciences industry group

-60.87%

Max: 18.05%
Q3: 4.78%
Median: 0.00%
Q1: -4.14%
Min: -17.05%
BNTX: -60.87%

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

Max: 18.05%
Q3: 4.78%
RVMD: 0.00%
Median: 0.00%
Q1: -4.14%
Min: -17.05%

BioNTech (BNTX) vs. Revolution Medicines (RVMD): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Revolution Medicines (RVMD) reports a negative operating margin of -188.88%, usually indicating that operating costs exceeded revenue at the operating-income line. Meanwhile BioNTech (BNTX) reports 30.28%, ranking against industry peers normally.

BNTX

Pharmaceuticals, Biotechnology & Life Sciences industry group

30.28%

Max: 83.12%
BNTX: 30.28%
Q3: 14.77%
Median: 0.00%
Q1: -78.82%
Min: -207.40%

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

-188.88%

Max: 83.12%
Q3: 14.77%
Median: 0.00%
Q1: -78.82%
RVMD: -188.88%
Min: -207.40%

BioNTech (BNTX) vs. Revolution Medicines (RVMD): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for BioNTech (BNTX) and Revolution Medicines (RVMD)
Metric	BNTX	RVMD
ROE (TTM)	-8.14%	-93.56%
ROA (TTM)	-4.04%	-32.13%
Net Margin (TTM)	-60.87%	0.00%
Operating Margin (TTM)	30.28%	-188.88%
Gross Margin (TTM)	76.73%	0.00%

Growth

Revenue Growth

Only one side can be read here: BioNTech (BNTX) reports revenue growth of 4.32%, ranked against its industry; Revolution Medicines (RVMD) has no revenue growth figure this period.

BioNTech (BNTX) vs. Revolution Medicines (RVMD): A comparison of their Revenue Growth across different time periods.

EPS Growth

Neither BioNTech (BNTX) nor Revolution Medicines (RVMD) reports a EPS growth value for this period, so a direct comparison isn't possible.

Growth Metrics

Growth metrics for BioNTech (BNTX) and Revolution Medicines (RVMD)
Metric	BNTX	RVMD
Revenue Growth (YoY)	4.32%	--
Revenue Growth (3Y CAGR)	-45.06%	--
EPS Growth (YoY)	--	--
EPS Growth (3Y CAGR)	--	--

Financial Strength

Current Ratio (MRQ)

Both BioNTech (BNTX) at 8.55 and Revolution Medicines (RVMD) at 8.36 carry current ratio within their industries’ typical mid-ranges, suggesting balanced short-term liquidity relative to peers.

BNTX

Pharmaceuticals, Biotechnology & Life Sciences industry group

8.55

Max: 25.13
Q3: 12.13
BNTX: 8.55
Median: 5.52
Q1: 2.47
Min: 0.10

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

8.36

Max: 25.13
Q3: 12.13
RVMD: 8.36
Median: 5.52
Q1: 2.47
Min: 0.10

BioNTech (BNTX) vs. Revolution Medicines (RVMD): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

BioNTech (BNTX) at 0.02 keeps leverage in the lower industry quartile, while Revolution Medicines (RVMD) at 0.50 runs a more typical debt-to-equity mix.

BNTX

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.02

Max: 1.42
Q3: 0.65
Median: 0.15
Q1: 0.02
BNTX: 0.02
Min: 0.00

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.50

Max: 1.42
Q3: 0.65
RVMD: 0.50
Median: 0.15
Q1: 0.02
Min: 0.00

BioNTech (BNTX) vs. Revolution Medicines (RVMD): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for BioNTech (BNTX) and Revolution Medicines (RVMD)
Metric	BNTX	RVMD
Current Ratio (MRQ)	8.55	8.36
Debt / Equity (MRQ)	0.02	0.50
Net Debt / EBITDA	--	--

Dividends

Dividend Yield (TTM)

Neither BioNTech (BNTX) nor Revolution Medicines (RVMD) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

BNTX

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

BNTX: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

RVMD: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

BioNTech (BNTX) vs. Revolution Medicines (RVMD): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Neither BioNTech (BNTX) nor Revolution Medicines (RVMD) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

BNTX

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

BNTX: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

RVMD: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

BioNTech (BNTX) vs. Revolution Medicines (RVMD): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for BioNTech (BNTX) and Revolution Medicines (RVMD)
Metric	BNTX	RVMD
Dividend Yield (TTM)	0.00%	0.00%
Dividend Payout Ratio (TTM)	0.00%	0.00%

Valuation

P/E Ratio (TTM)

Neither BioNTech (BNTX) nor Revolution Medicines (RVMD) reports a P/E ratio value for this period, so a direct comparison isn’t possible.

BNTX

Pharmaceuticals, Biotechnology & Life Sciences industry group

Max: 85.34
Q3: 43.46
Median: 26.69
Q1: 13.30
Min: 0.07
BNTX: --

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

Max: 85.34
Q3: 43.46
Median: 26.69
Q1: 13.30
Min: 0.07
RVMD: --

BioNTech (BNTX) vs. Revolution Medicines (RVMD): Neither stock reports P/E ratio, so the chart shows available benchmark boxes without value markers.

P/S Ratio (TTM)

BioNTech (BNTX) at 8.96 prices around its industry’s typical P/S ratio, while Revolution Medicines (RVMD) at 210.51 clears its benchmark range — RVMD looks notably rich on sales.

BNTX

Pharmaceuticals, Biotechnology & Life Sciences industry group

8.96

Max: 58.18
Q3: 25.77
BNTX: 8.96
Median: 7.30
Q1: 3.01
Min: 0.01

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

210.51

RVMD: 210.51
Max: 58.18
Q3: 25.77
Median: 7.30
Q1: 3.01
Min: 0.01

BioNTech (BNTX) vs. Revolution Medicines (RVMD): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

BioNTech (BNTX) at 1.09 sits in the lower P/B ratio quartile relative to book while Revolution Medicines (RVMD) at 17.31 prices above its industry range — a wide valuation gap against assets.

BNTX

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.09

Max: 13.53
Q3: 6.54
Median: 3.25
Q1: 1.69
BNTX: 1.09
Min: -5.59

RVMD

Pharmaceuticals, Biotechnology & Life Sciences industry group

17.31

RVMD: 17.31
Max: 13.53
Q3: 6.54
Median: 3.25
Q1: 1.69
Min: -5.59

BioNTech (BNTX) vs. Revolution Medicines (RVMD): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for BioNTech (BNTX) and Revolution Medicines (RVMD)
Metric	BNTX	RVMD
P/E Ratio (TTM)	--	--
P/S Ratio (TTM)	8.96	210.51
P/B Ratio (MRQ)	1.09	17.31
Free Cash Flow Yield (TTM)	-7.34%	-2.13%