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AVTR vs. TAK: Avantor vs. Takeda Pharmaceutical Stock Comparison

How do Avantor (AVTR) and Takeda Pharmaceutical (TAK) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Avantor (AVTR) and Takeda Pharmaceutical (TAK) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but AVTR is classified in Life Sciences Tools & Services while TAK is classified in Pharmaceuticals.

Avantor (AVTR) trades as ordinary local shares, while Takeda Pharmaceutical (TAK) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.

Company profile comparison for Avantor (AVTR) and Takeda Pharmaceutical (TAK)
Profile ItemAVTRTAK
NameAvantor, Inc.Takeda Pharmaceutical Co Ltd ADR
Country/RegionUnited StatesJapan
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryLife Sciences Tools & ServicesPharmaceuticals
GICS Sub-IndustryLife Sciences Tools & ServicesPharmaceuticals
Market Capitalization10.48 billion USD67.16 billion USD
CurrencyUSDUSD
ExchangeNYSENYSE
Listing DateMay 17, 2019January 5, 2010
Security TypeCommon StockADR

Price Performance

Cumulative Growth

AVTR
TAK
GSPC
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Avantor (AVTR) and Takeda Pharmaceutical (TAK). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Avantor (AVTR) and Takeda Pharmaceutical (TAK). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Avantor (AVTR) and Takeda Pharmaceutical (TAK)
MetricAVTRTAK
Total Return (1Y)36.41%54.54%
Total Return (3Y, Annualized)-5.02%18.39%
Total Return (5Y, Annualized)-16.62%9.29%

Risk Profile

Drawdown History

AVTR
TAK
GSPC
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Avantor (AVTR) and Takeda Pharmaceutical (TAK). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Takeda Pharmaceutical (TAK) reports a negative beta of -0.01, suggesting inverse market sensitivity over the measurement window. That is uncommon for ordinary equities and can reflect commodity-linked or hedge-like exposure, but it can also come from statistical noise. Avantor (AVTR) has a non-negative beta of 0.94.

Risk profile metrics for Avantor (AVTR) and Takeda Pharmaceutical (TAK)
MetricAVTRTAK
Volatility (1Y, Annualized)43.39%21.45%
Beta (5Y)0.94-0.01
Max Drawdown (5Y)-82.42%-24.83%
Avg. Volume (3M)8.56M2.61M

Risk-Adjusted Performance

Risk-Return Positioning

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AVTR and TAK are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Avantor (AVTR) and Takeda Pharmaceutical (TAK)
MetricAVTRTAK
Sharpe Ratio (1Y)0.742.34
Sortino Ratio (1Y)1.173.88

Profitability

ROE (TTM)

Both Avantor (AVTR) at 5.91% and Takeda Pharmaceutical (TAK) at 0.56% land near their industries’ usual ROE ranges, so capital efficiency looks broadly in line with peers on both sides.

AVTR

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.91%

Max
109.18%
Q3
6.23%
AVTR
5.91%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.56%

Max
109.18%
Q3
6.23%
TAK
0.56%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Avantor (AVTR) at 5.08% retains a top-quartile share of revenue as profit, ahead of Takeda Pharmaceutical (TAK) at 0.87%, which keeps about the industry-typical share.

AVTR

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.08%

Max
18.05%
AVTR
5.08%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.87%

Max
18.05%
Q3
4.78%
TAK
0.87%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Takeda Pharmaceutical (TAK) at 24.55% operates in the top operating margin quartile, ahead of Avantor (AVTR) at 8.19%, which runs around its industry’s norm.

AVTR

Pharmaceuticals, Biotechnology & Life Sciences industry group

8.19%

Max
83.12%
Q3
14.77%
AVTR
8.19%
Median
0.00%
Q1
-78.82%
Min
-207.40%

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

24.55%

Max
83.12%
TAK
24.55%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Avantor (AVTR) and Takeda Pharmaceutical (TAK)
MetricAVTRTAK
ROE (TTM)5.91%0.56%
ROA (TTM)2.83%3.27%
Net Margin (TTM)5.08%0.87%
Operating Margin (TTM)8.19%24.55%
Gross Margin (TTM)31.59%64.77%

Growth

Revenue Growth

Both Avantor (AVTR) at -3.41% and Takeda Pharmaceutical (TAK) at -1.66% post bottom-quartile revenue growth versus peers, pointing to weaker demand or pricing momentum than typical rivals.

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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their Revenue Growth across different time periods.

EPS Growth

Takeda Pharmaceutical (TAK) at 77.96% sits in the top EPS growth quartile, while Avantor (AVTR) at -175.00% is in the bottom quartile, showing a clear gap in earnings momentum.

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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Avantor (AVTR) and Takeda Pharmaceutical (TAK)
MetricAVTRTAK
Revenue Growth (YoY)-3.41%-1.66%
Revenue Growth (3Y CAGR)-4.46%3.81%
EPS Growth (YoY)-175.00%77.96%
EPS Growth (3Y CAGR)---16.01%

Financial Strength

Current Ratio (MRQ)

Both Avantor (AVTR) at 1.89 and Takeda Pharmaceutical (TAK) at 1.15 run current ratio in the tighter-liquidity quartile of industry peers, leaving thinner cushions against current liabilities than typical competitors.

AVTR

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.89

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
AVTR
1.89
Min
0.10

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.15

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
TAK
1.15
Min
0.10
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Avantor (AVTR) at 0.63 carries an industry-typical debt-to-equity mix, while Takeda Pharmaceutical (TAK) at 0.72 uses more debt funding than most peers.

AVTR

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.63

Max
1.42
Q3
0.65
AVTR
0.63
Median
0.15
Q1
0.02
Min
0.00

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.72

Max
1.42
TAK
0.72
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Avantor (AVTR) and Takeda Pharmaceutical (TAK)
MetricAVTRTAK
Current Ratio (MRQ)1.891.15
Debt / Equity (MRQ)0.630.72
Net Debt / EBITDA3.403.61

Dividends

Dividend Yield (TTM)

Avantor (AVTR) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Takeda Pharmaceutical (TAK) reports a yield of 953.28%, ranking against industry peers normally.

AVTR

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

AVTR
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

953.28%

TAK
953.28%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Takeda Pharmaceutical (TAK) reports payout ratio above 100% at 426.53%, meaning dividends exceeded current-period earnings; Avantor (AVTR) pays no dividend (payout 0.00%).

AVTR

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

AVTR
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

426.53%

TAK
426.53%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Avantor (AVTR) and Takeda Pharmaceutical (TAK)
MetricAVTRTAK
Dividend Yield (TTM)0.00%953.28%
Dividend Payout Ratio (TTM)0.00%426.53%

Valuation

P/E Ratio (TTM)

Avantor (AVTR) at 30.94 is near its industry’s usual P/E ratio, while Takeda Pharmaceutical (TAK) at 300.29 sits above its peer range — an unusually expensive price for TAK’s trailing earnings.

AVTR

Pharmaceuticals, Biotechnology & Life Sciences industry group

30.94

Max
85.34
Q3
43.46
AVTR
30.94
Median
26.69
Q1
13.30
Min
0.07

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

300.29

TAK
300.29
Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

Both Avantor (AVTR) at 1.58 and Takeda Pharmaceutical (TAK) at 0.01 fetch a relatively low price per dollar of sales, landing in the cheaper P/S ratio quartile of their industries.

AVTR

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.58

Max
58.18
Q3
25.77
Median
7.30
Q1
3.01
AVTR
1.58
Min
0.01

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.01

Max
58.18
Q3
25.77
Median
7.30
Q1
3.01
TAK
0.01
Min
0.01
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Takeda Pharmaceutical (TAK) at 1.43 sits in the lower P/B ratio quartile against book while Avantor (AVTR) at 1.80 is valued near its industry’s middle — TAK is cheaper on assets, though weigh it against ROE and asset quality.

AVTR

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.80

Max
13.53
Q3
6.54
Median
3.25
AVTR
1.80
Q1
1.69
Min
-5.59

TAK

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.43

Max
13.53
Q3
6.54
Median
3.25
Q1
1.69
TAK
1.43
Min
-5.59
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Avantor (AVTR) vs. Takeda Pharmaceutical (TAK): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Avantor (AVTR) and Takeda Pharmaceutical (TAK)
MetricAVTRTAK
P/E Ratio (TTM)30.94300.29
P/S Ratio (TTM)1.580.01
P/B Ratio (MRQ)1.801.43
Free Cash Flow Yield (TTM)4.21%1,014.61%