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ASND vs. MRK: Ascendis Pharma vs. Merck Stock Comparison

How do Ascendis Pharma (ASND) and Merck (MRK) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Ascendis Pharma (ASND) and Merck (MRK) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but ASND is classified in Biotechnology while MRK is classified in Pharmaceuticals.

Company profile comparison for Ascendis Pharma (ASND) and Merck (MRK)
Profile ItemASNDMRK
NameAscendis Pharma A/SMerck & Co., Inc.
Country/RegionDenmarkUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnologyPharmaceuticals
GICS Sub-IndustryBiotechnologyPharmaceuticals
Market Capitalization16.90 billion USD361.73 billion USD
CurrencyUSDUSD
ExchangeNasdaqNYSE
Listing DateJanuary 28, 2015January 2, 1962
Security TypeCommon StockCommon Stock

Price Performance

Cumulative Growth

ASND
MRK
GSPC
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Ascendis Pharma (ASND) vs. Merck (MRK), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Ascendis Pharma (ASND) and Merck (MRK). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Ascendis Pharma (ASND) and Merck (MRK). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Ascendis Pharma (ASND) and Merck (MRK)
MetricASNDMRK
Total Return (1Y)29.46%76.14%
Total Return (3Y, Annualized)40.62%16.48%
Total Return (5Y, Annualized)10.03%15.77%

Risk Profile

Drawdown History

ASND
MRK
GSPC
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Ascendis Pharma (ASND) vs. Merck (MRK), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Ascendis Pharma (ASND) and Merck (MRK). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Merck (MRK) is heavily traded at around 10.24M shares per day, whereas Ascendis Pharma (ASND) sees a more moderate 698.39K — larger orders in the latter may require more patience and tighter control over order sizing.

Risk profile metrics for Ascendis Pharma (ASND) and Merck (MRK)
MetricASNDMRK
Volatility (1Y, Annualized)38.62%30.24%
Beta (5Y)0.380.11
Max Drawdown (5Y)-55.93%-43.44%
Avg. Volume (3M)698.39K10.24M

Risk-Adjusted Performance

Risk-Return Positioning

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ASND and MRK are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Ascendis Pharma (ASND) and Merck (MRK)
MetricASNDMRK
Sharpe Ratio (1Y)0.652.38
Sortino Ratio (1Y)0.994.33

Profitability

ROE (TTM)

Ascendis Pharma (ASND) at 118.78% clears its industry range for ROE, a sharper capital-efficiency signal than Merck (MRK) at 5.06%, which is closer to a typical peer reading.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

118.78%

ASND
118.78%
Max
109.18%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.06%

Max
109.18%
Q3
6.23%
MRK
5.06%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Ascendis Pharma (ASND) at 70.85% converts revenue to bottom-line profit above its industry’s benchmark range, while Merck (MRK) at 3.64% keeps roughly the typical share for its industry.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

70.85%

ASND
70.85%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.64%

Max
18.05%
Q3
4.78%
MRK
3.64%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Ascendis Pharma (ASND) at 64.98% and Merck (MRK) at 35.22% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

64.98%

Max
83.12%
ASND
64.98%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

35.22%

Max
83.12%
MRK
35.22%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Ascendis Pharma (ASND) and Merck (MRK)
MetricASNDMRK
ROE (TTM)118.78%5.06%
ROA (TTM)9.58%11.29%
Net Margin (TTM)70.85%3.64%
Operating Margin (TTM)64.98%35.22%
Gross Margin (TTM)91.30%75.20%

Growth

Revenue Growth

Ascendis Pharma (ASND) at 98.03% sits in the top revenue growth quartile, while Merck (MRK) at 1.31% is closer to the peer norm — faster top-line expansion for ASND.

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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their Revenue Growth across different time periods.

EPS Growth

Only one side can be read here: Merck (MRK) reports EPS growth of 8.01%, ranked against its industry; Ascendis Pharma (ASND) has no EPS growth figure this period.

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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Ascendis Pharma (ASND) and Merck (MRK)
MetricASNDMRK
Revenue Growth (YoY)98.03%1.31%
Revenue Growth (3Y CAGR)141.43%3.12%
EPS Growth (YoY)--8.01%
EPS Growth (3Y CAGR)--8.43%

Financial Strength

Current Ratio (MRQ)

Ascendis Pharma (ASND) at 2.99 keeps current ratio within its industry’s typical mid-range, while Merck (MRK) at 1.35 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for MRK.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.99

Max
25.13
Q3
12.13
Median
5.52
ASND
2.99
Q1
2.47
Min
0.10

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.35

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
MRK
1.35
Min
0.10
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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Ascendis Pharma (ASND) at 0.31 carries an industry-typical debt-to-equity mix, while Merck (MRK) at 1.20 uses more debt funding than most peers.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.31

Max
1.42
Q3
0.65
ASND
0.31
Median
0.15
Q1
0.02
Min
0.00

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.20

Max
1.42
MRK
1.20
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Ascendis Pharma (ASND) and Merck (MRK)
MetricASNDMRK
Current Ratio (MRQ)2.991.35
Debt / Equity (MRQ)0.311.20
Net Debt / EBITDA-1.371.50

Dividends

Dividend Yield (TTM)

Ascendis Pharma (ASND) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Merck (MRK) reports a yield of 2.29%, ranking against industry peers normally.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ASND
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.29%

MRK
2.29%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Merck (MRK) reports payout ratio above 100% at 343.43%, meaning dividends exceeded current-period earnings; Ascendis Pharma (ASND) pays no dividend (payout 0.00%).

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ASND
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

343.43%

MRK
343.43%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Ascendis Pharma (ASND) and Merck (MRK)
MetricASNDMRK
Dividend Yield (TTM)0.00%2.29%
Dividend Payout Ratio (TTM)0.00%343.43%

Valuation

P/E Ratio (TTM)

Ascendis Pharma (ASND) at 19.68 is near its industry’s usual P/E ratio, while Merck (MRK) at 148.21 sits above its peer range — an unusually expensive price for MRK’s trailing earnings.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

19.68

Max
85.34
Q3
43.46
Median
26.69
ASND
19.68
Q1
13.30
Min
0.07

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

148.21

MRK
148.21
Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07
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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

On P/S ratio, both Ascendis Pharma (ASND) at 16.14 and Merck (MRK) at 5.37 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

16.14

Max
58.18
Q3
25.77
ASND
16.14
Median
7.30
Q1
3.01
Min
0.01

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.37

Max
58.18
Q3
25.77
Median
7.30
MRK
5.37
Q1
3.01
Min
0.01
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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Both Ascendis Pharma (ASND) at 10.45 and Merck (MRK) at 8.06 carry a premium to book value versus peers, sitting in the upper P/B ratio quartile of their industries.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

10.45

Max
13.53
ASND
10.45
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59

MRK

Pharmaceuticals, Biotechnology & Life Sciences industry group

8.06

Max
13.53
MRK
8.06
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59
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Ascendis Pharma (ASND) vs. Merck (MRK): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Ascendis Pharma (ASND) and Merck (MRK)
MetricASNDMRK
P/E Ratio (TTM)19.68148.21
P/S Ratio (TTM)16.145.37
P/B Ratio (MRQ)10.458.06
Free Cash Flow Yield (TTM)0.08%3.88%