ASND vs. INSM: A Head-to-Head Stock Comparison
Updated onHere’s a clear look at ASND and INSM, comparing key factors like historical performance, profitability, financial strength, growth, dividend, and valuation.
Company Overview
INSM’s market capitalization of 18.58 billion USD is significantly greater than ASND’s 10.52 billion USD, highlighting its more substantial market valuation.
INSM carries a higher beta at 0.79, indicating it’s more sensitive to market moves, while ASND (beta: 0.36) exhibits greater stability.
ASND trades as an American Depositary Receipt (ADR), offering U.S. investors a convenient way to access its foreign-listed shares. In contrast, INSM is a standard domestic listing.
| Symbol | ASND | INSM |
|---|---|---|
| Company Name | Ascendis Pharma A/S | Insmed Incorporated |
| Country | DK | US |
| Sector | Healthcare | Healthcare |
| Industry | Biotechnology | Medical - Pharmaceuticals |
| CEO | Jan Moller Mikkelsen | William H. Lewis |
| Price | 174.18 USD | 97.8 USD |
| Market Cap | 10.52 billion USD | 18.58 billion USD |
| Beta | 0.36 | 0.79 |
| Exchange | NASDAQ | NASDAQ |
| IPO Date | January 28, 2015 | June 1, 2000 |
| ADR | Yes | No |
Historical Performance
This chart compares the performance of ASND and INSM by tracking the growth of an initial $10,000 investment in each. Use the tabs to select the desired time period.
Data is adjusted for dividends and splits.
Profitability
Return on Equity
ASND
191.42%
Biotechnology Industry
- Max
- 72.39%
- Q3
- -6.30%
- Median
- -32.82%
- Q1
- -68.26%
- Min
- -147.61%
ASND’s Return on Equity of 191.42% is exceptionally high, placing it well beyond the typical range for the Biotechnology industry. This demonstrates a superior ability to generate profit from shareholder investments, though it could also be inflated by high financial leverage.
INSM
-446.98%
Medical - Pharmaceuticals Industry
- Max
- -11.51%
- Q3
- -11.51%
- Median
- -28.40%
- Q1
- -54.57%
- Min
- -54.57%
INSM has a negative Return on Equity of -446.98%. This indicates the company is generating a loss for its shareholders, which can be a result of unprofitability or negative shareholder equity and is often a sign of financial distress.
Return on Invested Capital
ASND
-50.64%
Biotechnology Industry
- Max
- 48.74%
- Q3
- -10.68%
- Median
- -31.65%
- Q1
- -52.92%
- Min
- -113.69%
ASND has a negative Return on Invested Capital of -50.64%. This indicates that its operations are failing to generate a profit on the total capital invested, signaling significant inefficiency or value destruction.
INSM
-56.09%
Medical - Pharmaceuticals Industry
- Max
- 3.07%
- Q3
- 0.40%
- Median
- -9.25%
- Q1
- -9.31%
- Min
- -9.31%
INSM has a negative Return on Invested Capital of -56.09%. This indicates that its operations are failing to generate a profit on the total capital invested, signaling significant inefficiency or value destruction.
Net Profit Margin
ASND
-92.67%
Biotechnology Industry
- Max
- 87.75%
- Q3
- -5.05%
- Median
- -103.44%
- Q1
- -1,032.77%
- Min
- -2,366.07%
ASND has a negative Net Profit Margin of -92.67%, indicating the company is operating at a net loss as its expenses exceeded its revenues.
INSM
-265.93%
Medical - Pharmaceuticals Industry
- Max
- -3.80%
- Q3
- -5.21%
- Median
- -8.76%
- Q1
- -9.40%
- Min
- -9.40%
INSM has a negative Net Profit Margin of -265.93%, indicating the company is operating at a net loss as its expenses exceeded its revenues.
Operating Profit Margin
ASND
-90.54%
Biotechnology Industry
- Max
- 87.75%
- Q3
- -3.28%
- Median
- -115.26%
- Q1
- -1,188.86%
- Min
- -2,943.30%
ASND has a negative Operating Profit Margin of -90.54%. This signifies the company is unprofitable at the operational level, as its core business expenses exceed its revenue.
INSM
-230.21%
Medical - Pharmaceuticals Industry
- Max
- 4.55%
- Q3
- 0.04%
- Median
- -2.01%
- Q1
- -7.08%
- Min
- -7.08%
INSM has a negative Operating Profit Margin of -230.21%. This signifies the company is unprofitable at the operational level, as its core business expenses exceed its revenue.
Profitability at a Glance
| Symbol | ASND | INSM |
|---|---|---|
| Return on Equity (TTM) | 191.42% | -446.98% |
| Return on Assets (TTM) | -32.19% | -56.21% |
| Return on Invested Capital (TTM) | -50.64% | -56.09% |
| Net Profit Margin (TTM) | -92.67% | -265.93% |
| Operating Profit Margin (TTM) | -90.54% | -230.21% |
| Gross Profit Margin (TTM) | 85.30% | 76.16% |
Financial Strength
Current Ratio
ASND
1.04
Biotechnology Industry
- Max
- 28.73
- Q3
- 13.97
- Median
- 6.31
- Q1
- 3.60
- Min
- 0.02
ASND’s Current Ratio of 1.04 falls into the lower quartile for the Biotechnology industry. This indicates a tighter liquidity situation and a more constrained capacity to handle short-term debt than many of its competitors.
INSM
5.86
Medical - Pharmaceuticals Industry
- Max
- 2.08
- Q3
- 2.08
- Median
- 1.96
- Q1
- 0.82
- Min
- 0.61
INSM’s Current Ratio of 5.86 is exceptionally high, placing it well outside the typical range for the Medical - Pharmaceuticals industry. This indicates a very strong liquidity position, though such a high ratio may also suggest that the company is not using its assets efficiently to generate profits.
Debt-to-Equity Ratio
ASND
-4.46
Biotechnology Industry
- Max
- 0.46
- Q3
- 0.22
- Median
- 0.06
- Q1
- 0.02
- Min
- 0.00
ASND has a Debt-to-Equity Ratio of -4.46, which indicates negative shareholder equity where liabilities exceed assets. This is a critical sign of financial distress.
INSM
11.53
Medical - Pharmaceuticals Industry
- Max
- 11.35
- Q3
- 6.06
- Median
- 3.76
- Q1
- 2.54
- Min
- 0.28
With a Debt-to-Equity Ratio of 11.53, INSM operates with exceptionally high leverage compared to the Medical - Pharmaceuticals industry norm. This suggests an aggressive reliance on debt financing, which can magnify returns but also significantly elevates financial risk.
Interest Coverage Ratio
ASND
-3.72
Biotechnology Industry
- Max
- 108.32
- Q3
- -0.55
- Median
- -8.49
- Q1
- -74.83
- Min
- -168.36
ASND has a negative Interest Coverage Ratio of -3.72. This indicates that its earnings were insufficient to cover even its operational costs, let alone its interest payments, signaling significant financial distress.
INSM
-10.72
Medical - Pharmaceuticals Industry
- Max
- 1.42
- Q3
- 0.39
- Median
- -3.07
- Q1
- -7.31
- Min
- -10.72
INSM has a negative Interest Coverage Ratio of -10.72. This indicates that its earnings were insufficient to cover even its operational costs, let alone its interest payments, signaling significant financial distress.
Financial Strength at a Glance
| Symbol | ASND | INSM |
|---|---|---|
| Current Ratio (TTM) | 1.04 | 5.86 |
| Quick Ratio (TTM) | 0.71 | 5.44 |
| Debt-to-Equity Ratio (TTM) | -4.46 | 11.53 |
| Debt-to-Asset Ratio (TTM) | 0.80 | 0.63 |
| Net Debt-to-EBITDA Ratio (TTM) | -1.34 | -0.80 |
| Interest Coverage Ratio (TTM) | -3.72 | -10.72 |
Growth
The following charts compare key year-over-year (YoY) growth metrics for ASND and INSM. These metrics are based on the companies’ annual financial reports.
Revenue Growth
Earnings Per Share (EPS) Growth
Free Cash Flow Growth
Dividend
Dividend Yield
ASND
0.00%
Biotechnology Industry
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
ASND currently does not pay a dividend, resulting in a yield of 0%. This is a common strategy for growth-focused companies that prioritize reinvesting earnings, though it may be less typical in mature, income-oriented sectors.
INSM
0.00%
Medical - Pharmaceuticals Industry
- Max
- 11.18%
- Q3
- 4.37%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
INSM currently does not pay a dividend, resulting in a yield of 0%. This is a common strategy for growth-focused companies that prioritize reinvesting earnings, though it may be less typical in mature, income-oriented sectors.
Dividend Payout Ratio
ASND
0.00%
Biotechnology Industry
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
ASND has a Dividend Payout Ratio of 0%, indicating it does not currently pay a dividend. This is a common strategy for growth-oriented companies that reinvest all profits back into the business.
INSM
0.00%
Medical - Pharmaceuticals Industry
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
INSM has a Dividend Payout Ratio of 0%, indicating it does not currently pay a dividend. This is a common strategy for growth-oriented companies that reinvest all profits back into the business.
Dividend at a Glance
| Symbol | ASND | INSM |
|---|---|---|
| Dividend Yield (TTM) | 0.00% | 0.00% |
| Dividend Payout Ratio (TTM) | 0.00% | 0.00% |
Valuation
Price-to-Earnings Ratio
ASND
-25.98
Biotechnology Industry
- Max
- 78.44
- Q3
- 48.98
- Median
- 20.50
- Q1
- 12.64
- Min
- 2.14
ASND has a negative P/E Ratio of -25.98. This occurs when a company has negative earnings (a net loss), making the ratio unsuitable for valuation analysis.
INSM
-17.46
Medical - Pharmaceuticals Industry
- Max
- --
- Q3
- --
- Median
- --
- Q1
- --
- Min
- --
INSM has a negative P/E Ratio of -17.46. This occurs when a company has negative earnings (a net loss), making the ratio unsuitable for valuation analysis.
Forward P/E to Growth Ratio
ASND
-2.36
Biotechnology Industry
- Max
- 2.29
- Q3
- 1.10
- Median
- 0.49
- Q1
- 0.16
- Min
- 0.02
ASND has a negative Forward PEG Ratio of -2.36. This typically results from negative earnings or forecasts of declining future earnings, making the ratio not meaningful for valuation.
INSM
2.71
Medical - Pharmaceuticals Industry
- Max
- 2.76
- Q3
- 2.07
- Median
- 1.38
- Q1
- 0.69
- Min
- 0.00
A Forward PEG Ratio of 2.71 places INSM in the upper quartile for the Medical - Pharmaceuticals industry. This suggests the stock is potentially expensive compared to its peers relative to its growth forecast, which may warrant caution.
Price-to-Sales Ratio
ASND
24.22
Biotechnology Industry
- Max
- 110.90
- Q3
- 59.76
- Median
- 11.33
- Q1
- 4.45
- Min
- 0.17
ASND’s P/S Ratio of 24.22 aligns with the market consensus for the Biotechnology industry. This suggests its valuation, based on sales, is seen as standard and is on par with its competitors.
INSM
48.76
Medical - Pharmaceuticals Industry
- Max
- 5.74
- Q3
- 5.74
- Median
- 5.66
- Q1
- 2.83
- Min
- 0.07
With a P/S Ratio of 48.76, INSM trades at a valuation that eclipses even the highest in the Medical - Pharmaceuticals industry. This implies the market has priced in exceptionally optimistic scenarios for future revenue growth, posing considerable valuation risk.
Price-to-Book Ratio
ASND
-46.77
Biotechnology Industry
- Max
- 15.78
- Q3
- 7.44
- Median
- 3.31
- Q1
- 1.58
- Min
- 0.31
The P/B Ratio is often not a primary valuation metric for the Biotechnology industry.
INSM
178.38
Medical - Pharmaceuticals Industry
- Max
- 130.20
- Q3
- 55.61
- Median
- 10.51
- Q1
- 5.88
- Min
- 1.39
The P/B Ratio is often not a primary valuation metric for the Medical - Pharmaceuticals industry.
Valuation at a Glance
| Symbol | ASND | INSM |
|---|---|---|
| Price-to-Earnings Ratio (P/E, TTM) | -25.98 | -17.46 |
| Forward PEG Ratio (TTM) | -2.36 | 2.71 |
| Price-to-Sales Ratio (P/S, TTM) | 24.22 | 48.76 |
| Price-to-Book Ratio (P/B, TTM) | -46.77 | 178.38 |
| Price-to-Free Cash Flow Ratio (P/FCF, TTM) | -29.03 | -23.54 |
| EV-to-EBITDA (TTM) | -37.74 | -20.76 |
| EV-to-Sales (TTM) | 25.11 | 50.70 |