AMGN vs. NVO: Amgen vs. Novo Nordisk Stock Comparison
How do Amgen (AMGN) and Novo Nordisk (NVO) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.
Company Profile
Amgen (AMGN) and Novo Nordisk (NVO) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but AMGN is classified in Biotechnology while NVO is classified in Pharmaceuticals.
Amgen (AMGN) trades as ordinary local shares, while Novo Nordisk (NVO) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.
| Profile Item | AMGN | NVO |
|---|---|---|
| Name | Amgen Inc. Common Stock | Novo Nordisk A/S Sponsored ADR |
| Country/Region | United States | Denmark |
| GICS Sector | Health Care | Health Care |
| GICS Industry Group | Pharmaceuticals, Biotechnology & Life Sciences | Pharmaceuticals, Biotechnology & Life Sciences |
| GICS Industry | Biotechnology | Pharmaceuticals |
| GICS Sub-Industry | Biotechnology | Pharmaceuticals |
| Market Capitalization | 249.05 billion USD | 177.74 billion USD |
| Currency | USD | USD |
| Exchange | Nasdaq | NYSE |
| Listing Date | June 17, 1983 | April 30, 1981 |
| Security Type | Common Stock | ADR |
Price Performance
Cumulative Growth
Trailing Returns
Calendar-Year Returns
Performance Metrics
| Metric | AMGN | NVO |
|---|---|---|
| Total Return (1Y) | 48.82% | -5.29% |
| Total Return (3Y, Annualized) | 24.31% | -23.41% |
| Total Return (5Y, Annualized) | 20.67% | -4.13% |
Risk Profile
Drawdown History
Return Distribution
Risk Metrics
| Metric | AMGN | NVO |
|---|---|---|
| Volatility (1Y, Annualized) | 29.12% | 45.98% |
| Beta (5Y) | 0.43 | 0.67 |
| Max Drawdown (5Y) | -24.86% | -74.70% |
| Avg. Volume (3M) | 2.76M | 12.11M |
Risk-Adjusted Performance
Risk-Return Positioning
Risk-Adjusted Metrics
| Metric | AMGN | NVO |
|---|---|---|
| Sharpe Ratio (1Y) | 1.53 | -0.21 |
| Sortino Ratio (1Y) | 2.36 | -0.28 |
Profitability
ROE (TTM)
Both Amgen (AMGN) at 78.35% and Novo Nordisk (NVO) at 58.38% sit in the top peer quartile for ROE, suggesting each generates more profit from shareholders’ equity than typical industry peers.
AMGN
Pharmaceuticals, Biotechnology & Life Sciences industry group
78.35%
- Max
- 109.18%
- AMGN
- 78.35%
- Q3
- 6.23%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
58.38%
- Max
- 109.18%
- NVO
- 58.38%
- Q3
- 6.23%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
Net Margin (TTM)
Both Amgen (AMGN) at 24.14% and Novo Nordisk (NVO) at 33.92% keep an unusually large share of revenue as bottom-line profit — each net margin clears its industry’s benchmark range.
AMGN
Pharmaceuticals, Biotechnology & Life Sciences industry group
24.14%
- AMGN
- 24.14%
- Max
- 18.05%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
33.92%
- NVO
- 33.92%
- Max
- 18.05%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
Operating Margin (TTM)
Both Amgen (AMGN) at 35.79% and Novo Nordisk (NVO) at 40.05% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.
AMGN
Pharmaceuticals, Biotechnology & Life Sciences industry group
35.79%
- Max
- 83.12%
- AMGN
- 35.79%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
40.05%
- Max
- 83.12%
- NVO
- 40.05%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
Profitability Metrics
| Metric | AMGN | NVO |
|---|---|---|
| ROE (TTM) | 78.35% | 58.38% |
| ROA (TTM) | 8.91% | 19.05% |
| Net Margin (TTM) | 24.14% | 33.92% |
| Operating Margin (TTM) | 35.79% | 40.05% |
| Gross Margin (TTM) | 72.47% | 83.33% |
Growth
Revenue Growth
Both Amgen (AMGN) at 9.95% and Novo Nordisk (NVO) at 6.43% land near their industries' usual revenue growth ranges, so top-line momentum looks broadly in line with peers on both sides.
EPS Growth
Amgen (AMGN) at 88.23% sits in the top EPS growth quartile, while Novo Nordisk (NVO) at 1.77% is closer to the peer norm — faster per-share earnings growth for AMGN.
Growth Metrics
| Metric | AMGN | NVO |
|---|---|---|
| Revenue Growth (YoY) | 9.95% | 6.43% |
| Revenue Growth (3Y CAGR) | 11.77% | 20.43% |
| EPS Growth (YoY) | 88.23% | 1.77% |
| EPS Growth (3Y CAGR) | 5.52% | 23.52% |
Financial Strength
Current Ratio (MRQ)
Both Amgen (AMGN) at 1.48 and Novo Nordisk (NVO) at 0.85 run current ratio in the tighter-liquidity quartile of industry peers, leaving thinner cushions against current liabilities than typical competitors.
AMGN
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.48
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- Q1
- 2.47
- AMGN
- 1.48
- Min
- 0.10
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.85
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- Q1
- 2.47
- NVO
- 0.85
- Min
- 0.10
Debt / Equity (MRQ)
Novo Nordisk (NVO) at 0.62 is near its industry mid-range for debt-to-equity ratio, while Amgen (AMGN) at 3.76 sits above its benchmark range, pointing to a heavier debt load relative to equity.
AMGN
Pharmaceuticals, Biotechnology & Life Sciences industry group
3.76
- AMGN
- 3.76
- Max
- 1.42
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.62
- Max
- 1.42
- Q3
- 0.65
- NVO
- 0.62
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
Financial Strength Metrics
| Metric | AMGN | NVO |
|---|---|---|
| Current Ratio (MRQ) | 1.48 | 0.85 |
| Debt / Equity (MRQ) | 3.76 | 0.62 |
| Net Debt / EBITDA | 2.31 | 0.49 |
Dividends
Dividend Yield (TTM)
Both Amgen (AMGN) at 2.16% and Novo Nordisk (NVO) at 29.03% yield above their industries’ entire benchmark ranges — high enough that dividend safety, not income, becomes the first question.
AMGN
Pharmaceuticals, Biotechnology & Life Sciences industry group
2.16%
- AMGN
- 2.16%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
29.03%
- NVO
- 29.03%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Payout Ratio (TTM)
Both Amgen (AMGN) at 57.62% and Novo Nordisk (NVO) at 45.36% pay out more of their earnings than any of their industry peers — the thinnest cover in their groups, so dividend headroom deserves attention.
AMGN
Pharmaceuticals, Biotechnology & Life Sciences industry group
57.62%
- AMGN
- 57.62%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
45.36%
- NVO
- 45.36%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Metrics
| Metric | AMGN | NVO |
|---|---|---|
| Dividend Yield (TTM) | 2.16% | 29.03% |
| Dividend Payout Ratio (TTM) | 57.62% | 45.36% |
Valuation
P/E Ratio (TTM)
Novo Nordisk (NVO) at 10.18 sits in the cheaper P/E ratio quartile, while Amgen (AMGN) at 26.69 is closer to its industry’s usual earnings multiple — a discount for NVO, though growth and earnings durability still matter.
AMGN
Pharmaceuticals, Biotechnology & Life Sciences industry group
26.69
- Max
- 85.34
- Q3
- 43.46
- AMGN
- 26.69
- Median
- 26.69
- Q1
- 13.30
- Min
- 0.07
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
10.18
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- Q1
- 13.30
- NVO
- 10.18
- Min
- 0.07
P/S Ratio (TTM)
Novo Nordisk (NVO) at 0.53 sits in the cheaper P/S ratio quartile while Amgen (AMGN) at 6.40 prices around its industry’s middle — NVO costs less per dollar of sales, though read it alongside growth and margins.
AMGN
Pharmaceuticals, Biotechnology & Life Sciences industry group
6.40
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- AMGN
- 6.40
- Q1
- 3.01
- Min
- 0.01
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.53
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- Q1
- 3.01
- NVO
- 0.53
- Min
- 0.01
P/B Ratio (MRQ)
Novo Nordisk (NVO) at 5.43 sits near its industry’s typical P/B ratio, while Amgen (AMGN) at 17.35 prices above its benchmark range — AMGN looks rich relative to book.
AMGN
Pharmaceuticals, Biotechnology & Life Sciences industry group
17.35
- AMGN
- 17.35
- Max
- 13.53
- Q3
- 6.54
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
5.43
- Max
- 13.53
- Q3
- 6.54
- NVO
- 5.43
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
Valuation Metrics
| Metric | AMGN | NVO |
|---|---|---|
| P/E Ratio (TTM) | 26.69 | 10.18 |
| P/S Ratio (TTM) | 6.40 | 0.53 |
| P/B Ratio (MRQ) | 17.35 | 5.43 |
| Free Cash Flow Yield (TTM) | 2.96% | 18.43% |