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ALNY vs. JAZZ: Alnylam Pharmaceuticals vs. Jazz Pharmaceuticals Stock Comparison

How do Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but ALNY is classified in Biotechnology while JAZZ is classified in Pharmaceuticals.

Company profile comparison for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ)
Profile ItemALNYJAZZ
NameAlnylam Pharmaceuticals, Inc.Jazz Pharmaceuticals plc
Country/RegionUnited StatesIreland
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnologyPharmaceuticals
GICS Sub-IndustryBiotechnologyPharmaceuticals
Market Capitalization20.89 billion USD15.07 billion USD
CurrencyUSDUSD
ExchangeNasdaqNasdaq
Listing DateJune 1, 2004June 1, 2007
Security TypeCommon StockCommon Stock

Price Performance

Cumulative Growth

ALNY
JAZZ
GSPC
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ)
MetricALNYJAZZ
Total Return (1Y)-64.57%84.44%
Total Return (3Y, Annualized)-1.58%27.57%
Total Return (5Y, Annualized)-3.13%12.88%

Risk Profile

Drawdown History

ALNY
JAZZ
GSPC
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ)
MetricALNYJAZZ
Volatility (1Y, Annualized)54.08%38.74%
Beta (5Y)0.450.33
Max Drawdown (5Y)-68.25%-42.03%
Avg. Volume (3M)1.90M878.80K

Risk-Adjusted Performance

Risk-Return Positioning

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ALNY and JAZZ are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ)
MetricALNYJAZZ
Sharpe Ratio (1Y)-1.272.07
Sortino Ratio (1Y)-1.454.14

Profitability

ROE (TTM)

Alnylam Pharmaceuticals (ALNY) at 138.07% clears its industry range for ROE, a sharper capital-efficiency signal than Jazz Pharmaceuticals (JAZZ) at 5.05%, which is closer to a typical peer reading.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

138.07%

ALNY
138.07%
Max
109.18%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

JAZZ

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.05%

Max
109.18%
Q3
6.23%
JAZZ
5.05%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Alnylam Pharmaceuticals (ALNY) at 52.85% converts revenue to bottom-line profit above its industry’s benchmark range, while Jazz Pharmaceuticals (JAZZ) at 4.37% keeps roughly the typical share for its industry.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

52.85%

ALNY
52.85%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%

JAZZ

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.37%

Max
18.05%
Q3
4.78%
JAZZ
4.37%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Alnylam Pharmaceuticals (ALNY) at 23.72% and Jazz Pharmaceuticals (JAZZ) at 30.17% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

23.72%

Max
83.12%
ALNY
23.72%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

JAZZ

Pharmaceuticals, Biotechnology & Life Sciences industry group

30.17%

Max
83.12%
JAZZ
30.17%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ)
MetricALNYJAZZ
ROE (TTM)138.07%5.05%
ROA (TTM)9.51%6.92%
Net Margin (TTM)52.85%4.37%
Operating Margin (TTM)23.72%30.17%
Gross Margin (TTM)77.28%91.10%

Growth

Revenue Growth

Alnylam Pharmaceuticals (ALNY) at 65.19% sits in the top revenue growth quartile, while Jazz Pharmaceuticals (JAZZ) at 4.88% is closer to the peer norm — faster top-line expansion for ALNY.

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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their Revenue Growth across different time periods.

EPS Growth

Only one side can be read here: Jazz Pharmaceuticals (JAZZ) reports EPS growth of -167.51%, ranked against its industry; Alnylam Pharmaceuticals (ALNY) has no EPS growth figure this period.

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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ)
MetricALNYJAZZ
Revenue Growth (YoY)65.19%4.88%
Revenue Growth (3Y CAGR)52.98%5.26%
EPS Growth (YoY)---167.51%
EPS Growth (3Y CAGR)----

Financial Strength

Current Ratio (MRQ)

Alnylam Pharmaceuticals (ALNY) at 2.48 keeps current ratio within its industry’s typical mid-range, while Jazz Pharmaceuticals (JAZZ) at 1.82 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for JAZZ.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.48

Max
25.13
Q3
12.13
Median
5.52
ALNY
2.48
Q1
2.47
Min
0.10

JAZZ

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.82

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
JAZZ
1.82
Min
0.10
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Both Alnylam Pharmaceuticals (ALNY) at 0.83 and Jazz Pharmaceuticals (JAZZ) at 1.35 lean more heavily on debt funding than most peers, landing in the higher-leverage quartile of their industries.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.83

Max
1.42
ALNY
0.83
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00

JAZZ

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.35

Max
1.42
JAZZ
1.35
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ)
MetricALNYJAZZ
Current Ratio (MRQ)2.481.82
Debt / Equity (MRQ)0.831.35
Net Debt / EBITDA-0.571.39

Dividends

Dividend Yield (TTM)

Neither Alnylam Pharmaceuticals (ALNY) nor Jazz Pharmaceuticals (JAZZ) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ALNY
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

JAZZ

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

JAZZ
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Neither Alnylam Pharmaceuticals (ALNY) nor Jazz Pharmaceuticals (JAZZ) pays a dividend this period — they may reinvest, use buybacks, or simply not return cash through dividends.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ALNY
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

JAZZ

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

JAZZ
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ)
MetricALNYJAZZ
Dividend Yield (TTM)0.00%0.00%
Dividend Payout Ratio (TTM)0.00%0.00%

Valuation

P/E Ratio (TTM)

Alnylam Pharmaceuticals (ALNY) at 7.88 sits in the cheaper P/E ratio quartile, while Jazz Pharmaceuticals (JAZZ) at 69.46 sits in the richer quartile — a clear split in what investors pay for each dollar of trailing earnings.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.88

Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
ALNY
7.88
Min
0.07

JAZZ

Pharmaceuticals, Biotechnology & Life Sciences industry group

69.46

Max
85.34
JAZZ
69.46
Q3
43.46
Median
26.69
Q1
13.30
Min
0.07
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

On P/S ratio, both Alnylam Pharmaceuticals (ALNY) at 4.17 and Jazz Pharmaceuticals (JAZZ) at 3.19 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.17

Max
58.18
Q3
25.77
Median
7.30
ALNY
4.17
Q1
3.01
Min
0.01

JAZZ

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.19

Max
58.18
Q3
25.77
Median
7.30
JAZZ
3.19
Q1
3.01
Min
0.01
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

On P/B ratio, both Alnylam Pharmaceuticals (ALNY) at 5.79 and Jazz Pharmaceuticals (JAZZ) at 3.59 are valued close to their industries’ norm against book — neither stands out from peers.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.79

Max
13.53
Q3
6.54
ALNY
5.79
Median
3.25
Q1
1.69
Min
-5.59

JAZZ

Pharmaceuticals, Biotechnology & Life Sciences industry group

3.59

Max
13.53
Q3
6.54
JAZZ
3.59
Median
3.25
Q1
1.69
Min
-5.59
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Alnylam Pharmaceuticals (ALNY) vs. Jazz Pharmaceuticals (JAZZ): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Alnylam Pharmaceuticals (ALNY) and Jazz Pharmaceuticals (JAZZ)
MetricALNYJAZZ
P/E Ratio (TTM)7.8869.46
P/S Ratio (TTM)4.173.19
P/B Ratio (MRQ)5.793.59
Free Cash Flow Yield (TTM)1.57%11.16%