TAK vs. UTHR: Takeda Pharmaceutical vs. United Therapeutics Stock Comparison
How do Takeda Pharmaceutical (TAK) and United Therapeutics (UTHR) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.
Company Profile
Takeda Pharmaceutical (TAK) and United Therapeutics (UTHR) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but TAK is classified in Pharmaceuticals while UTHR is classified in Biotechnology.
United Therapeutics (UTHR) trades as ordinary local shares, while Takeda Pharmaceutical (TAK) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.
| Profile Item | TAK | UTHR |
|---|---|---|
| Name | Takeda Pharmaceutical Co Ltd ADR | United Therapeutics Corporation |
| Country/Region | Japan | United States |
| GICS Sector | Health Care | Health Care |
| GICS Industry Group | Pharmaceuticals, Biotechnology & Life Sciences | Pharmaceuticals, Biotechnology & Life Sciences |
| GICS Industry | Pharmaceuticals | Biotechnology |
| GICS Sub-Industry | Pharmaceuticals | Biotechnology |
| Market Capitalization | 67.16 billion USD | 23.94 billion USD |
| Currency | USD | USD |
| Exchange | NYSE | Nasdaq |
| Listing Date | January 5, 2010 | June 17, 1999 |
| Security Type | ADR | Common Stock |
Price Performance
Cumulative Growth
Trailing Returns
Calendar-Year Returns
Performance Metrics
| Metric | TAK | UTHR |
|---|---|---|
| Total Return (1Y) | 54.54% | 28.77% |
| Total Return (3Y, Annualized) | 18.39% | 37.63% |
| Total Return (5Y, Annualized) | 9.29% | 23.78% |
Risk Profile
Drawdown History
Return Distribution
Risk Metrics
Takeda Pharmaceutical (TAK) reports a negative beta of -0.01, suggesting inverse market sensitivity over the measurement window. That is uncommon for ordinary equities and can reflect commodity-linked or hedge-like exposure, but it can also come from statistical noise. United Therapeutics (UTHR) has a non-negative beta of 0.49.
| Metric | TAK | UTHR |
|---|---|---|
| Volatility (1Y, Annualized) | 21.45% | 35.00% |
| Beta (5Y) | -0.01 | 0.49 |
| Max Drawdown (5Y) | -24.83% | -33.00% |
| Avg. Volume (3M) | 2.61M | 694.55K |
Risk-Adjusted Performance
Risk-Return Positioning
Risk-Adjusted Metrics
| Metric | TAK | UTHR |
|---|---|---|
| Sharpe Ratio (1Y) | 2.34 | 0.70 |
| Sortino Ratio (1Y) | 3.88 | 1.29 |
Profitability
ROE (TTM)
United Therapeutics (UTHR) at 19.13% sits in the top ROE quartile, while Takeda Pharmaceutical (TAK) at 0.56% is closer to the peer norm — stronger capital efficiency for UTHR.
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.56%
- Max
- 109.18%
- Q3
- 6.23%
- TAK
- 0.56%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
UTHR
Pharmaceuticals, Biotechnology & Life Sciences industry group
19.13%
- Max
- 109.18%
- UTHR
- 19.13%
- Q3
- 6.23%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
Net Margin (TTM)
United Therapeutics (UTHR) at 38.61% converts revenue to bottom-line profit above its industry’s benchmark range, while Takeda Pharmaceutical (TAK) at 0.87% keeps roughly the typical share for its industry.
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.87%
- Max
- 18.05%
- Q3
- 4.78%
- TAK
- 0.87%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
UTHR
Pharmaceuticals, Biotechnology & Life Sciences industry group
38.61%
- UTHR
- 38.61%
- Max
- 18.05%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
Operating Margin (TTM)
Both Takeda Pharmaceutical (TAK) at 24.55% and United Therapeutics (UTHR) at 28.99% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
24.55%
- Max
- 83.12%
- TAK
- 24.55%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
UTHR
Pharmaceuticals, Biotechnology & Life Sciences industry group
28.99%
- Max
- 83.12%
- UTHR
- 28.99%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
Profitability Metrics
| Metric | TAK | UTHR |
|---|---|---|
| ROE (TTM) | 0.56% | 19.13% |
| ROA (TTM) | 3.27% | 10.91% |
| Net Margin (TTM) | 0.87% | 38.61% |
| Operating Margin (TTM) | 24.55% | 28.99% |
| Gross Margin (TTM) | 64.77% | 86.34% |
Growth
Revenue Growth
United Therapeutics (UTHR) at 10.61% is around its peer norm for revenue growth, while Takeda Pharmaceutical (TAK) at -1.66% drops into the bottom quartile, signaling weaker demand or pricing momentum.
EPS Growth
Takeda Pharmaceutical (TAK) at 77.96% sits in the top EPS growth quartile, while United Therapeutics (UTHR) at 13.07% is closer to the peer norm — faster per-share earnings growth for TAK.
Growth Metrics
| Metric | TAK | UTHR |
|---|---|---|
| Revenue Growth (YoY) | -1.66% | 10.61% |
| Revenue Growth (3Y CAGR) | 3.81% | 18.02% |
| EPS Growth (YoY) | 77.96% | 13.07% |
| EPS Growth (3Y CAGR) | -16.01% | 22.92% |
Financial Strength
Current Ratio (MRQ)
United Therapeutics (UTHR) at 4.61 keeps current ratio within its industry’s typical mid-range, while Takeda Pharmaceutical (TAK) at 1.15 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for TAK.
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.15
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- Q1
- 2.47
- TAK
- 1.15
- Min
- 0.10
UTHR
Pharmaceuticals, Biotechnology & Life Sciences industry group
4.61
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- UTHR
- 4.61
- Q1
- 2.47
- Min
- 0.10
Debt / Equity (MRQ)
Only one side’s leverage can be read here: Takeda Pharmaceutical (TAK) carries debt-to-equity ratio of 0.72 against its industry range, while United Therapeutics (UTHR) reports no figure this period.
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.72
- Max
- 1.42
- TAK
- 0.72
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
UTHR
Pharmaceuticals, Biotechnology & Life Sciences industry group
--
- Max
- 1.42
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
- UTHR
- --
Financial Strength Metrics
| Metric | TAK | UTHR |
|---|---|---|
| Current Ratio (MRQ) | 1.15 | 4.61 |
| Debt / Equity (MRQ) | 0.72 | -- |
| Net Debt / EBITDA | 3.61 | -1.53 |
Dividends
Dividend Yield (TTM)
United Therapeutics (UTHR) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Takeda Pharmaceutical (TAK) reports a yield of 953.28%, ranking against industry peers normally.
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
953.28%
- TAK
- 953.28%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
UTHR
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- UTHR
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Payout Ratio (TTM)
Takeda Pharmaceutical (TAK) reports payout ratio above 100% at 426.53%, meaning dividends exceeded current-period earnings; United Therapeutics (UTHR) pays no dividend (payout 0.00%).
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
426.53%
- TAK
- 426.53%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
UTHR
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- UTHR
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Metrics
| Metric | TAK | UTHR |
|---|---|---|
| Dividend Yield (TTM) | 953.28% | 0.00% |
| Dividend Payout Ratio (TTM) | 426.53% | 0.00% |
Valuation
P/E Ratio (TTM)
United Therapeutics (UTHR) at 21.22 is near its industry’s usual P/E ratio, while Takeda Pharmaceutical (TAK) at 300.29 sits above its peer range — an unusually expensive price for TAK’s trailing earnings.
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
300.29
- TAK
- 300.29
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- Q1
- 13.30
- Min
- 0.07
UTHR
Pharmaceuticals, Biotechnology & Life Sciences industry group
21.22
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- UTHR
- 21.22
- Q1
- 13.30
- Min
- 0.07
P/S Ratio (TTM)
Takeda Pharmaceutical (TAK) at 0.01 sits in the cheaper P/S ratio quartile while United Therapeutics (UTHR) at 7.51 prices around its industry’s middle — TAK costs less per dollar of sales, though read it alongside growth and margins.
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.01
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- Q1
- 3.01
- TAK
- 0.01
- Min
- 0.01
UTHR
Pharmaceuticals, Biotechnology & Life Sciences industry group
7.51
- Max
- 58.18
- Q3
- 25.77
- UTHR
- 7.51
- Median
- 7.30
- Q1
- 3.01
- Min
- 0.01
P/B Ratio (MRQ)
Takeda Pharmaceutical (TAK) at 1.43 sits in the lower P/B ratio quartile against book while United Therapeutics (UTHR) at 3.80 is valued near its industry’s middle — TAK is cheaper on assets, though weigh it against ROE and asset quality.
TAK
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.43
- Max
- 13.53
- Q3
- 6.54
- Median
- 3.25
- Q1
- 1.69
- TAK
- 1.43
- Min
- -5.59
UTHR
Pharmaceuticals, Biotechnology & Life Sciences industry group
3.80
- Max
- 13.53
- Q3
- 6.54
- UTHR
- 3.80
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
Valuation Metrics
| Metric | TAK | UTHR |
|---|---|---|
| P/E Ratio (TTM) | 300.29 | 21.22 |
| P/S Ratio (TTM) | 0.01 | 7.51 |
| P/B Ratio (MRQ) | 1.43 | 3.80 |
| Free Cash Flow Yield (TTM) | 1,014.61% | 1.90% |