NBIX vs. SYK: A Head-to-Head Stock Comparison

Updated on November 17, 2025

Here’s a clear look at NBIX and SYK, comparing key factors like historical performance, profitability, financial strength, growth, dividend, and valuation.

Company Profile

Symbol	NBIX	SYK
Company Name	Neurocrine Biosciences, Inc.	Stryker Corporation
Country	United States	United States
GICS Sector	Health Care	Health Care
GICS Industry	Biotechnology	Health Care Equipment & Supplies
Market Capitalization	14.96 billion USD	135.77 billion USD
Exchange	NasdaqGS	NYSE
Listing Date	May 23, 1996	March 17, 1980
Security Type	Common Stock	Common Stock

Historical Performance

This chart compares the performance of NBIX and SYK by tracking the growth of an initial $10,000 investment in each. Use the tabs to select the desired time period. Data is adjusted for dividends and splits.

NBIX vs. SYK: Growth of a $10,000 investment over the past one year.

Historical Performance at a Glance

Symbol	NBIX	SYK
5-Day Price Return	4.77%	-2.09%
13-Week Price Return	21.00%	-5.75%
26-Week Price Return	23.36%	-7.56%
52-Week Price Return	21.00%	-4.00%
Month-to-Date Return	4.76%	-0.34%
Year-to-Date Return	9.90%	-1.40%
10-Day Avg. Volume	1.44M	1.92M
3-Month Avg. Volume	0.92M	1.37M
3-Month Volatility	31.39%	18.60%
Beta	0.28	0.90

Profitability

Return on Equity (TTM)

NBIX

15.82%

Biotechnology Industry

Max: 97.92%
Q3: 11.99%
Median: -19.30%
Q1: -51.29%
Min: -132.03%

In the upper quartile for the Biotechnology industry, NBIX’s Return on Equity of 15.82% signals a highly effective use of shareholder capital to drive profitability compared to most of its peers.

SYK

13.92%

Health Care Equipment & Supplies Industry

Max: 29.93%
Q3: 16.99%
Median: 9.28%
Q1: 5.10%
Min: -12.52%

SYK’s Return on Equity of 13.92% is on par with the norm for the Health Care Equipment & Supplies industry, indicating its profitability relative to shareholder equity is typical for the sector.

NBIX vs. SYK: A comparison of their Return on Equity (TTM) against their respective Biotechnology and Health Care Equipment & Supplies industry benchmarks.

Net Profit Margin (TTM)

NBIX

15.95%

Biotechnology Industry

Max: 73.34%
Q3: 18.98%
Median: -12.96%
Q1: -105.72%
Min: -259.82%

NBIX’s Net Profit Margin of 15.95% is aligned with the median group of its peers in the Biotechnology industry. This indicates its ability to convert revenue into profit is typical for the sector.

SYK

12.07%

Health Care Equipment & Supplies Industry

Max: 24.41%
Q3: 13.71%
Median: 10.08%
Q1: 5.96%
Min: -5.58%

SYK’s Net Profit Margin of 12.07% is aligned with the median group of its peers in the Health Care Equipment & Supplies industry. This indicates its ability to convert revenue into profit is typical for the sector.

NBIX vs. SYK: A comparison of their Net Profit Margin (TTM) against their respective Biotechnology and Health Care Equipment & Supplies industry benchmarks.

Operating Profit Margin (TTM)

NBIX

20.51%

Biotechnology Industry

Max: 78.85%
Q3: 21.90%
Median: -13.30%
Q1: -109.94%
Min: -278.10%

NBIX’s Operating Profit Margin of 20.51% is around the midpoint for the Biotechnology industry, indicating that its efficiency in managing core business operations is typical for the sector.

SYK

15.04%

Health Care Equipment & Supplies Industry

Max: 31.09%
Q3: 18.11%
Median: 15.07%
Q1: 8.48%
Min: -0.28%

SYK’s Operating Profit Margin of 15.04% is around the midpoint for the Health Care Equipment & Supplies industry, indicating that its efficiency in managing core business operations is typical for the sector.

NBIX vs. SYK: A comparison of their Operating Profit Margin (TTM) against their respective Biotechnology and Health Care Equipment & Supplies industry benchmarks.

Profitability at a Glance

Symbol	NBIX	SYK
Return on Equity (TTM)	15.82%	13.92%
Return on Assets (TTM)	11.00%	6.46%
Net Profit Margin (TTM)	15.95%	12.07%
Operating Profit Margin (TTM)	20.51%	15.04%
Gross Profit Margin (TTM)	98.37%	64.59%

Financial Strength

Current Ratio (MRQ)

NBIX

3.38

Biotechnology Industry

Max: 16.97
Q3: 8.39
Median: 4.11
Q1: 2.64
Min: 0.74

NBIX’s Current Ratio of 3.38 aligns with the median group of the Biotechnology industry, indicating that its short-term liquidity is in line with its sector peers.

SYK

1.85

Health Care Equipment & Supplies Industry

Max: 5.19
Q3: 3.00
Median: 2.13
Q1: 1.44
Min: 0.86

SYK’s Current Ratio of 1.85 aligns with the median group of the Health Care Equipment & Supplies industry, indicating that its short-term liquidity is in line with its sector peers.

NBIX vs. SYK: A comparison of their Current Ratio (MRQ) against their respective Biotechnology and Health Care Equipment & Supplies industry benchmarks.

Debt-to-Equity Ratio (MRQ)

NBIX

0.00

Biotechnology Industry

Max: 1.92
Q3: 0.79
Median: 0.12
Q1: 0.00
Min: 0.00

NBIX’s Debt-to-Equity Ratio of 0.00 is typical for the Biotechnology industry, indicating its use of leverage is in line with the sector norm. This suggests a balanced approach to its capital structure.

SYK

0.68

Health Care Equipment & Supplies Industry

Max: 1.61
Q3: 0.76
Median: 0.45
Q1: 0.14
Min: 0.00

SYK’s Debt-to-Equity Ratio of 0.68 is typical for the Health Care Equipment & Supplies industry, indicating its use of leverage is in line with the sector norm. This suggests a balanced approach to its capital structure.

NBIX vs. SYK: A comparison of their Debt-to-Equity Ratio (MRQ) against their respective Biotechnology and Health Care Equipment & Supplies industry benchmarks.

Interest Coverage Ratio (TTM)

NBIX

6.75

Biotechnology Industry

Max: 72.37
Q3: 1.03
Median: -9.59
Q1: -65.05
Min: -163.11

NBIX’s Interest Coverage Ratio of 6.75 is in the upper quartile for the Biotechnology industry, signifying a strong and healthy capacity to meet its interest payments from operating profits.

SYK

14.59

Health Care Equipment & Supplies Industry

Max: 56.35
Q3: 25.56
Median: 9.60
Q1: 3.78
Min: -26.49

SYK’s Interest Coverage Ratio of 14.59 is positioned comfortably within the norm for the Health Care Equipment & Supplies industry, indicating a standard and healthy capacity to cover its interest payments.

NBIX vs. SYK: A comparison of their Interest Coverage Ratio (TTM) against their respective Biotechnology and Health Care Equipment & Supplies industry benchmarks.

Financial Strength at a Glance

Symbol	NBIX	SYK
Current Ratio (MRQ)	3.38	1.85
Quick Ratio (MRQ)	3.00	0.94
Debt-to-Equity Ratio (MRQ)	0.00	0.68
Interest Coverage Ratio (TTM)	6.75	14.59

Growth

Revenue Growth

NBIX vs. SYK: A side-by-side comparison of their Revenue Growth for the MRQ (YoY), TTM (YoY), 3-Year CAGR, and 5-Year CAGR periods.

EPS Growth

NBIX vs. SYK: A side-by-side comparison of their EPS Growth for the MRQ (YoY), TTM (YoY), 3-Year CAGR, and 5-Year CAGR periods.

Dividend

Dividend Yield (TTM)

NBIX

0.00%

Biotechnology Industry

Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

NBIX currently does not pay a dividend, resulting in a yield of 0%. This is a common strategy for growth-focused companies that prioritize reinvesting earnings, though it may be less typical in mature, income-oriented sectors.

SYK

0.94%

Health Care Equipment & Supplies Industry

Max: 4.15%
Q3: 1.76%
Median: 0.79%
Q1: 0.00%
Min: 0.00%

SYK’s Dividend Yield of 0.94% is consistent with its peers in the Health Care Equipment & Supplies industry, providing a dividend return that is standard for its sector.

NBIX vs. SYK: A comparison of their Dividend Yield (TTM) against their respective Biotechnology and Health Care Equipment & Supplies industry benchmarks.

Dividend Payout Ratio (TTM)

NBIX

0.00%

Biotechnology Industry

Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

NBIX has a Dividend Payout Ratio of 0%, indicating it does not currently pay a dividend. This is a common strategy for growth-oriented companies that reinvest all profits back into the business.

SYK

43.09%

Health Care Equipment & Supplies Industry

Max: 160.00%
Q3: 66.60%
Median: 27.49%
Q1: 0.00%
Min: 0.00%

SYK’s Dividend Payout Ratio of 43.09% is within the typical range for the Health Care Equipment & Supplies industry, suggesting a balanced approach between shareholder payouts and company reinvestment.

NBIX vs. SYK: A comparison of their Dividend Payout Ratio (TTM) against their respective Biotechnology and Health Care Equipment & Supplies industry benchmarks.

Dividend at a Glance

Symbol	NBIX	SYK
Dividend Yield (TTM)	0.00%	0.94%
Dividend Payout Ratio (TTM)	0.00%	43.09%

Valuation

Price-to-Earnings Ratio (TTM)

NBIX

34.67

Biotechnology Industry

Max: 40.44
Q3: 39.37
Median: 22.12
Q1: 15.76
Min: 3.48

NBIX’s P/E Ratio of 34.67 is within the middle range for the Biotechnology industry. This suggests its valuation is in line with the sector average, representing neither a significant premium nor a discount compared to its peers.

SYK

45.87

Health Care Equipment & Supplies Industry

Max: 67.29
Q3: 47.01
Median: 30.94
Q1: 23.91
Min: 10.79

SYK’s P/E Ratio of 45.87 is within the middle range for the Health Care Equipment & Supplies industry. This suggests its valuation is in line with the sector average, representing neither a significant premium nor a discount compared to its peers.

NBIX vs. SYK: A comparison of their Price-to-Earnings Ratio (TTM) against their respective Biotechnology and Health Care Equipment & Supplies industry benchmarks.

Price-to-Sales Ratio (TTM)

NBIX

5.53

Biotechnology Industry

Max: 92.67
Q3: 41.36
Median: 8.45
Q1: 4.46
Min: 0.97

NBIX’s P/S Ratio of 5.53 aligns with the market consensus for the Biotechnology industry. This suggests its valuation, based on sales, is seen as standard and is on par with its competitors.

SYK

5.54

Health Care Equipment & Supplies Industry

Max: 9.49
Q3: 5.41
Median: 2.86
Q1: 2.07
Min: 0.74

SYK’s P/S Ratio of 5.54 is in the upper echelon for the Health Care Equipment & Supplies industry. This means the company is valued richly on its revenue stream compared to its peers, suggesting the stock is priced for a high level of future performance.

NBIX vs. SYK: A comparison of their Price-to-Sales Ratio (TTM) against their respective Biotechnology and Health Care Equipment & Supplies industry benchmarks.

Price-to-Book Ratio (MRQ)

NBIX

4.64

Biotechnology Industry

Max: 22.72
Q3: 10.68
Median: 4.55
Q1: 2.44
Min: 0.59

NBIX’s P/B Ratio of 4.64 is within the conventional range for the Biotechnology industry. This shows a balanced market view, where the stock’s price is neither at a significant premium nor a discount to the book value of its peers.

SYK

6.49

Health Care Equipment & Supplies Industry

Max: 10.85
Q3: 6.56
Median: 3.53
Q1: 2.36
Min: 0.71

SYK’s P/B Ratio of 6.49 is within the conventional range for the Health Care Equipment & Supplies industry. This shows a balanced market view, where the stock’s price is neither at a significant premium nor a discount to the book value of its peers.

NBIX vs. SYK: A comparison of their Price-to-Book Ratio (MRQ) against their respective Biotechnology and Health Care Equipment & Supplies industry benchmarks.

Valuation at a Glance

Symbol	NBIX	SYK
Price-to-Earnings Ratio (TTM)	34.67	45.87
Price-to-Sales Ratio (TTM)	5.53	5.54
Price-to-Book Ratio (MRQ)	4.64	6.49
Price-to-Free Cash Flow Ratio (TTM)	25.02	33.15