ISRG vs. ONC: A Head-to-Head Stock Comparison
Updated onHere’s a clear look at ISRG and ONC, comparing key factors like historical performance, profitability, financial strength, growth, dividend, and valuation.
Company Profile
ISRG is a standard domestic listing, while ONC trades as an American Depositary Receipt (ADR), offering U.S. investors access to its foreign-listed shares.
| Symbol | ISRG | ONC |
|---|---|---|
| Company Name | Intuitive Surgical, Inc. | BeOne Medicines Ltd. |
| Country | United States | Switzerland |
| GICS Sector | Health Care | Health Care |
| GICS Industry | Health Care Equipment & Supplies | Biotechnology |
| Market Capitalization | 168.90 billion USD | 36.75 billion USD |
| Exchange | NasdaqGS | NasdaqGS |
| Listing Date | June 16, 2000 | February 3, 2016 |
| Security Type | Common Stock | ADR |
Historical Performance
This chart compares the performance of ISRG and ONC by tracking the growth of an initial $10,000 investment in each. Use the tabs to select the desired time period. Data is adjusted for dividends and splits.
Historical Performance at a Glance
| Symbol | ISRG | ONC |
|---|---|---|
| 5-Day Price Return | 0.27% | 5.48% |
| 13-Week Price Return | -14.37% | 12.19% |
| 26-Week Price Return | -20.39% | 21.44% |
| 52-Week Price Return | -1.68% | 20.61% |
| Month-to-Date Return | -2.07% | 5.15% |
| Year-to-Date Return | -9.73% | 55.58% |
| 10-Day Avg. Volume | 1.89M | 3.74M |
| 3-Month Avg. Volume | 1.83M | 2.83M |
| 3-Month Volatility | 21.88% | 44.26% |
| Beta | 1.63 | 0.61 |
Profitability
Return on Equity (TTM)
ISRG
15.55%
Health Care Equipment & Supplies Industry
- Max
- 34.53%
- Q3
- 19.38%
- Median
- 9.52%
- Q1
- 4.86%
- Min
- -7.58%
ISRG’s Return on Equity of 15.55% is on par with the norm for the Health Care Equipment & Supplies industry, indicating its profitability relative to shareholder equity is typical for the sector.
ONC
-12.94%
Biotechnology Industry
- Max
- 77.14%
- Q3
- 10.76%
- Median
- -20.08%
- Q1
- -42.71%
- Min
- -119.20%
ONC has a negative Return on Equity of -12.94%. This indicates the company is generating a loss for its shareholders, which can be a result of unprofitability or negative shareholder equity and is often a sign of financial distress.
Net Profit Margin (TTM)
ISRG
28.51%
Health Care Equipment & Supplies Industry
- Max
- 23.34%
- Q3
- 13.06%
- Median
- 9.53%
- Q1
- 5.96%
- Min
- -3.87%
ISRG’s Net Profit Margin of 28.51% is exceptionally high, placing it well beyond the typical range for the Health Care Equipment & Supplies industry. This demonstrates outstanding operational efficiency and a strong competitive advantage in converting revenue into profit.
ONC
-10.58%
Biotechnology Industry
- Max
- 59.44%
- Q3
- 16.21%
- Median
- -11.49%
- Q1
- -167.42%
- Min
- -409.07%
ONC has a negative Net Profit Margin of -10.58%, indicating the company is operating at a net loss as its expenses exceeded its revenues.
Operating Profit Margin (TTM)
ISRG
28.80%
Health Care Equipment & Supplies Industry
- Max
- 29.44%
- Q3
- 17.80%
- Median
- 13.95%
- Q1
- 8.73%
- Min
- -3.56%
An Operating Profit Margin of 28.80% places ISRG in the upper quartile for the Health Care Equipment & Supplies industry. This signals a strong ability to translate revenue into operating profit, outperforming most of its competitors in core business efficiency.
ONC
-7.30%
Biotechnology Industry
- Max
- 60.62%
- Q3
- 20.76%
- Median
- -12.41%
- Q1
- -181.14%
- Min
- -482.02%
ONC has a negative Operating Profit Margin of -7.30%. This signifies the company is unprofitable at the operational level, as its core business expenses exceed its revenue.
Profitability at a Glance
| Symbol | ISRG | ONC |
|---|---|---|
| Return on Equity (TTM) | 15.55% | -12.94% |
| Return on Assets (TTM) | 13.75% | -7.59% |
| Net Profit Margin (TTM) | 28.51% | -10.58% |
| Operating Profit Margin (TTM) | 28.80% | -7.30% |
| Gross Profit Margin (TTM) | 66.61% | 84.66% |
Financial Strength
Current Ratio (MRQ)
ISRG
5.64
Health Care Equipment & Supplies Industry
- Max
- 4.90
- Q3
- 3.05
- Median
- 2.14
- Q1
- 1.49
- Min
- 0.86
ISRG’s Current Ratio of 5.64 is exceptionally high, placing it well outside the typical range for the Health Care Equipment & Supplies industry. This indicates a very strong liquidity position, though such a high ratio may also suggest that the company is not using its assets efficiently to generate profits.
ONC
1.95
Biotechnology Industry
- Max
- 19.31
- Q3
- 9.38
- Median
- 4.54
- Q1
- 2.45
- Min
- 0.76
ONC’s Current Ratio of 1.95 falls into the lower quartile for the Biotechnology industry. This indicates a tighter liquidity situation and a more constrained capacity to handle short-term debt than many of its competitors.
Debt-to-Equity Ratio (MRQ)
ISRG
0.00
Health Care Equipment & Supplies Industry
- Max
- 1.49
- Q3
- 0.71
- Median
- 0.45
- Q1
- 0.14
- Min
- 0.00
Falling into the lower quartile for the Health Care Equipment & Supplies industry, ISRG’s Debt-to-Equity Ratio of 0.00 points to a conservative financing strategy. This results in lower financial risk but potentially limits strategic investments compared to more leveraged competitors.
ONC
0.32
Biotechnology Industry
- Max
- 1.35
- Q3
- 0.64
- Median
- 0.09
- Q1
- 0.00
- Min
- 0.00
ONC’s Debt-to-Equity Ratio of 0.32 is typical for the Biotechnology industry, indicating its use of leverage is in line with the sector norm. This suggests a balanced approach to its capital structure.
Interest Coverage Ratio (TTM)
ISRG
--
Health Care Equipment & Supplies Industry
- Max
- 58.29
- Q3
- 25.56
- Median
- 9.06
- Q1
- 3.60
- Min
- -28.92
Interest Coverage Ratio data for ISRG is currently unavailable.
ONC
-132.16
Biotechnology Industry
- Max
- 72.37
- Q3
- 1.91
- Median
- -7.81
- Q1
- -63.90
- Min
- -153.80
ONC has a negative Interest Coverage Ratio of -132.16. This indicates that its earnings were insufficient to cover even its operational costs, let alone its interest payments, signaling significant financial distress.
Financial Strength at a Glance
| Symbol | ISRG | ONC |
|---|---|---|
| Current Ratio (MRQ) | 5.64 | 1.95 |
| Quick Ratio (MRQ) | 4.89 | 1.66 |
| Debt-to-Equity Ratio (MRQ) | 0.00 | 0.32 |
| Interest Coverage Ratio (TTM) | -- | -132.16 |
Growth
Revenue Growth
EPS Growth
Dividend
Dividend Yield (TTM)
ISRG
0.00%
Health Care Equipment & Supplies Industry
- Max
- 4.05%
- Q3
- 1.76%
- Median
- 0.71%
- Q1
- 0.00%
- Min
- 0.00%
ISRG currently does not pay a dividend, resulting in a yield of 0%. This is a common strategy for growth-focused companies that prioritize reinvesting earnings, though it may be less typical in mature, income-oriented sectors.
ONC
0.16%
Biotechnology Industry
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
ONC’s Dividend Yield of 0.16% is exceptionally high, placing it well above the typical range for the Biotechnology industry. While this may seem attractive, an unusually high yield can sometimes be a warning sign, reflecting a falling stock price or market concerns about the dividend’s sustainability.
Dividend Payout Ratio (TTM)
ISRG
0.00%
Health Care Equipment & Supplies Industry
- Max
- 160.00%
- Q3
- 72.47%
- Median
- 27.49%
- Q1
- 0.00%
- Min
- 0.00%
ISRG has a Dividend Payout Ratio of 0%, indicating it does not currently pay a dividend. This is a common strategy for growth-oriented companies that reinvest all profits back into the business.
ONC
0.00%
Biotechnology Industry
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
ONC has a Dividend Payout Ratio of 0%, indicating it does not currently pay a dividend. This is a common strategy for growth-oriented companies that reinvest all profits back into the business.
Dividend at a Glance
| Symbol | ISRG | ONC |
|---|---|---|
| Dividend Yield (TTM) | 0.00% | 0.16% |
| Dividend Payout Ratio (TTM) | 0.00% | 0.00% |
Valuation
Price-to-Earnings Ratio (TTM)
ISRG
66.01
Health Care Equipment & Supplies Industry
- Max
- 73.48
- Q3
- 51.69
- Median
- 34.31
- Q1
- 25.74
- Min
- 11.47
A P/E Ratio of 66.01 places ISRG in the upper quartile for the Health Care Equipment & Supplies industry. This high valuation relative to peers suggests the market holds elevated expectations for the company’s future growth.
ONC
--
Biotechnology Industry
- Max
- 60.14
- Q3
- 38.17
- Median
- 29.01
- Q1
- 15.12
- Min
- 0.00
P/E Ratio data for ONC is currently unavailable.
Price-to-Sales Ratio (TTM)
ISRG
18.82
Health Care Equipment & Supplies Industry
- Max
- 9.53
- Q3
- 5.26
- Median
- 3.39
- Q1
- 2.13
- Min
- 0.00
With a P/S Ratio of 18.82, ISRG trades at a valuation that eclipses even the highest in the Health Care Equipment & Supplies industry. This implies the market has priced in exceptionally optimistic scenarios for future revenue growth, posing considerable valuation risk.
ONC
9.24
Biotechnology Industry
- Max
- 76.98
- Q3
- 36.53
- Median
- 9.49
- Q1
- 4.49
- Min
- 0.00
ONC’s P/S Ratio of 9.24 aligns with the market consensus for the Biotechnology industry. This suggests its valuation, based on sales, is seen as standard and is on par with its competitors.
Price-to-Book Ratio (MRQ)
ISRG
10.85
Health Care Equipment & Supplies Industry
- Max
- 10.85
- Q3
- 5.98
- Median
- 3.48
- Q1
- 2.43
- Min
- 0.69
ISRG’s P/B Ratio of 10.85 is in the upper tier for the Health Care Equipment & Supplies industry. This indicates that investors are paying a premium relative to the company’s net assets, a valuation that hinges on its ability to generate superior profits.
ONC
8.99
Biotechnology Industry
- Max
- 20.53
- Q3
- 9.76
- Median
- 4.77
- Q1
- 2.49
- Min
- 0.59
ONC’s P/B Ratio of 8.99 is within the conventional range for the Biotechnology industry. This shows a balanced market view, where the stock’s price is neither at a significant premium nor a discount to the book value of its peers.
Valuation at a Glance
| Symbol | ISRG | ONC |
|---|---|---|
| Price-to-Earnings Ratio (TTM) | 66.01 | -- |
| Price-to-Sales Ratio (TTM) | 18.82 | 9.24 |
| Price-to-Book Ratio (MRQ) | 10.85 | 8.99 |
| Price-to-Free Cash Flow Ratio (TTM) | 86.31 | -- |