ISRG vs. MCK: Intuitive Surgical vs. McKesson Stock Comparison

June 13, 2026

This page compares Intuitive Surgical (ISRG) with McKesson (MCK) using performance and risk, profitability, financial strength, growth, dividends, and valuation metrics.

Performance

Cumulative Growth

ISRG

MCK

Intuitive Surgical (ISRG) vs. McKesson (MCK): Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Intuitive Surgical (ISRG) and McKesson (MCK). Returns over one year are annualized.

Performance at a Glance

Performance metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
1-Year Return	-19.87%	7.72%

Risk

Drawdown

ISRG

MCK

Intuitive Surgical (ISRG) vs. McKesson (MCK): Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Intuitive Surgical (ISRG) has an aggressive beta of 1.45, indicating higher sensitivity to broad-market moves, while McKesson (MCK) is defensive at 0.30 and tends to be less market-sensitive — they sit on opposite ends of the beta spectrum.

Risk at a Glance

Risk metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
1-Year Volatility	30.70%	29.15%
Beta	1.45	0.30
3-Month Avg. Volume	2.16M	1.01M

Company Profile

Intuitive Surgical (ISRG) and McKesson (MCK) both fall under the Health Care Equipment & Services industry group, but ISRG is classified in Health Care Equipment & Supplies while MCK is classified in Health Care Providers & Services.

Company profile comparison for Intuitive Surgical (ISRG) and McKesson (MCK)
Profile Item	ISRG	MCK
Name	Intuitive Surgical, Inc.	McKesson Corporation
Country/Region	United States	United States
GICS Sector	Health Care	Health Care
GICS Industry Group	Health Care Equipment & Services	Health Care Equipment & Services
GICS Industry	Health Care Equipment & Supplies	Health Care Providers & Services
GICS Sub-Industry	Health Care Equipment	Health Care Distributors
Market Capitalization	145.58 billion USD	94.25 billion USD
Currency	USD	USD
Exchange	Nasdaq	NYSE
Listing Date	June 16, 2000	November 10, 1994
Security Type	Common Stock	Common Stock

Valuation

Price-to-Earnings Ratio (TTM)

McKesson (MCK) at 20.41 is near its industry’s usual P/E ratio, while Intuitive Surgical (ISRG) at 50.01 sits in the richer quartile — ISRG needs stronger growth or earnings quality to justify the premium.

ISRG

Health Care Equipment & Services industry group

50.01

Max: 80.40
ISRG: 50.01
Q3: 44.58
Median: 28.09
Q1: 19.76
Min: 0.91

MCK

Health Care Equipment & Services industry group

20.41

Max: 80.40
Q3: 44.58
Median: 28.09
MCK: 20.41
Q1: 19.76
Min: 0.91

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their P/E ratio against the Health Care Equipment & Services industry group benchmark.

Price-to-Sales Ratio (TTM)

McKesson (MCK) at 0.23 sits in the cheaper P/S ratio quartile while Intuitive Surgical (ISRG) at 13.76 prices above its industry range — a wide gap in sales valuation between them.

ISRG

Health Care Equipment & Services industry group

13.76

ISRG: 13.76
Max: 8.62
Q3: 4.20
Median: 1.94
Q1: 1.01
Min: 0.04

MCK

Health Care Equipment & Services industry group

0.23

Max: 8.62
Q3: 4.20
Median: 1.94
Q1: 1.01
MCK: 0.23
Min: 0.04

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their P/S ratio against the Health Care Equipment & Services industry group benchmark.

Price-to-Book Ratio (MRQ)

McKesson (MCK) reports a negative P/B ratio of -43.32, meaning negative book equity — the multiple itself is not meaningful for valuation. Meanwhile Intuitive Surgical (ISRG) reports 8.34, ranking against industry peers normally.

ISRG

Health Care Equipment & Services industry group

8.34

Max: 11.03
ISRG: 8.34
Q3: 5.50
Median: 2.78
Q1: 1.47
Min: -2.18

MCK

Health Care Equipment & Services industry group

-43.32

Max: 11.03
Q3: 5.50
Median: 2.78
Q1: 1.47
Min: -2.18
MCK: -43.32

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their P/B ratio against the Health Care Equipment & Services industry group benchmark.

Valuation at a Glance

Valuation metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
Price-to-Earnings Ratio (TTM)	50.01	20.41
Price-to-Sales Ratio (TTM)	13.76	0.23
Price-to-Book Ratio (MRQ)	8.34	-43.32
Free Cash Flow Yield	1.55%	6.00%

Profitability

Return on Equity (TTM)

Capital efficiency shows on one side only: Intuitive Surgical (ISRG) earns 17.23% on shareholders’ equity, ranked against its industry; McKesson (MCK) has no ROE this period.

ISRG

Health Care Equipment & Services industry group

17.23%

Max: 53.65%
ISRG: 17.23%
Q3: 12.73%
Median: 3.57%
Q1: -17.96%
Min: -59.21%

MCK

Health Care Equipment & Services industry group

Max: 53.65%
Q3: 12.73%
Median: 3.57%
Q1: -17.96%
Min: -59.21%
MCK: --

Intuitive Surgical (ISRG) vs. McKesson (MCK): MCK does not report ROE, so it has no value marker; ISRG is benchmarked against the Health Care Equipment & Services industry group.

Net Profit Margin (TTM)

Intuitive Surgical (ISRG) at 28.15% retains a top-quartile share of revenue as profit, ahead of McKesson (MCK) at 1.18%, which keeps about the industry-typical share.

ISRG

Health Care Equipment & Services industry group

28.15%

Max: 30.40%
ISRG: 28.15%
Q3: 7.96%
Median: 1.27%
Q1: -9.77%
Min: -34.34%

MCK

Health Care Equipment & Services industry group

1.18%

Max: 30.40%
Q3: 7.96%
Median: 1.27%
MCK: 1.18%
Q1: -9.77%
Min: -34.34%

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their net margin against the Health Care Equipment & Services industry group benchmark.

Operating Profit Margin (TTM)

Intuitive Surgical (ISRG) at 30.87% operates in the top operating margin quartile, ahead of McKesson (MCK) at 2.21%, which runs around its industry’s norm.

ISRG

Health Care Equipment & Services industry group

30.87%

Max: 35.33%
ISRG: 30.87%
Q3: 11.89%
Median: 5.44%
Q1: -4.59%
Min: -25.61%

MCK

Health Care Equipment & Services industry group

2.21%

Max: 35.33%
Q3: 11.89%
Median: 5.44%
MCK: 2.21%
Q1: -4.59%
Min: -25.61%

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their operating margin against the Health Care Equipment & Services industry group benchmark.

Profitability at a Glance

Profitability metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
Return on Equity (TTM)	17.23%	--
Return on Assets (TTM)	10.24%	4.99%
Net Profit Margin (TTM)	28.15%	1.18%
Operating Profit Margin (TTM)	30.87%	2.21%
Gross Profit Margin (TTM)	66.29%	3.60%

Growth

Revenue Growth

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their Revenue Growth across different time periods.

Revenue Growth at a Glance

Revenue growth metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
1-Year Revenue Growth	20.51%	12.36%
3-Year Revenue CAGR	17.39%	13.39%

EPS Growth

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their EPS Growth across different time periods.

EPS Growth at a Glance

EPS growth metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
1-Year EPS Growth	22.59%	49.22%
3-Year EPS CAGR	29.19%	15.31%

Financial Strength

Current Ratio (MRQ)

Intuitive Surgical (ISRG) at 4.61 carries current ratio above its industry’s typical mid-range, while McKesson (MCK) at 0.85 runs in the tighter-liquidity quartile — different working-capital profiles, both worth examining.

ISRG

Health Care Equipment & Services industry group

4.61

Max: 7.79
ISRG: 4.61
Q3: 4.29
Median: 1.95
Q1: 1.33
Min: 0.04

MCK

Health Care Equipment & Services industry group

0.85

Max: 7.79
Q3: 4.29
Median: 1.95
Q1: 1.33
MCK: 0.85
Min: 0.04

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their current ratio against the Health Care Equipment & Services industry group benchmark.

Debt-to-Equity Ratio (MRQ)

Neither Intuitive Surgical (ISRG) nor McKesson (MCK) reports a debt-to-equity ratio value for this period, so a direct comparison isn’t possible.

ISRG

Health Care Equipment & Services industry group

Max: 2.02
Q3: 1.01
Median: 0.60
Q1: 0.16
Min: 0.00
ISRG: --

MCK

Health Care Equipment & Services industry group

Max: 2.02
Q3: 1.01
Median: 0.60
Q1: 0.16
Min: 0.00
MCK: --

Intuitive Surgical (ISRG) vs. McKesson (MCK): Neither stock reports debt-to-equity ratio, so the chart shows available benchmark boxes without value markers.

Financial Strength at a Glance

Financial strength metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
Current Ratio (MRQ)	4.61	0.85
Debt-to-Equity Ratio (MRQ)	--	--
Net Debt / EBITDA	-1.16	0.70

Dividends

Dividend Yield (TTM)

Intuitive Surgical (ISRG) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile McKesson (MCK) reports a yield of 0.42%, ranking against industry peers normally.

ISRG

Health Care Equipment & Services industry group

0.00%

ISRG: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

MCK

Health Care Equipment & Services industry group

0.42%

MCK: 0.42%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their dividend yield against the Health Care Equipment & Services industry group benchmark.

Dividend Payout Ratio (TTM)

Intuitive Surgical (ISRG) pays no dividend (payout 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile McKesson (MCK) reports a payout of 8.26%, ranking against industry peers normally.

ISRG

Health Care Equipment & Services industry group

0.00%

ISRG: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

MCK

Health Care Equipment & Services industry group

8.26%

MCK: 8.26%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their payout ratio against the Health Care Equipment & Services industry group benchmark.

Dividends at a Glance

Dividend metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
Dividend Yield (TTM)	0.00%	0.42%
Dividend Payout Ratio (TTM)	0.00%	8.26%