ISRG vs. MCK: Intuitive Surgical vs. McKesson Stock Comparison

July 23, 2026

How do Intuitive Surgical (ISRG) and McKesson (MCK) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Intuitive Surgical (ISRG) and McKesson (MCK) both fall under the Health Care Equipment & Services industry group, but ISRG is classified in Health Care Equipment & Supplies while MCK is classified in Health Care Providers & Services.

Company profile comparison for Intuitive Surgical (ISRG) and McKesson (MCK)
Profile Item	ISRG	MCK
Name	Intuitive Surgical, Inc.	McKesson Corporation
Country/Region	United States	United States
GICS Sector	Health Care	Health Care
GICS Industry Group	Health Care Equipment & Services	Health Care Equipment & Services
GICS Industry	Health Care Equipment & Supplies	Health Care Providers & Services
GICS Sub-Industry	Health Care Equipment	Health Care Distributors
Market Capitalization	123.98 billion USD	97.04 billion USD
Currency	USD	USD
Exchange	Nasdaq	NYSE
Listing Date	June 16, 2000	November 10, 1994
Security Type	Common Stock	Common Stock

Price Performance

Cumulative Growth

ISRG

MCK

GSPC

Intuitive Surgical (ISRG) vs. McKesson (MCK), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Intuitive Surgical (ISRG) and McKesson (MCK). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Intuitive Surgical (ISRG) and McKesson (MCK). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
Total Return (1Y)	-32.17%	17.01%
Total Return (3Y, Annualized)	1.31%	26.58%
Total Return (5Y, Annualized)	2.13%	33.94%

Risk Profile

Drawdown History

ISRG

MCK

GSPC

Intuitive Surgical (ISRG) vs. McKesson (MCK), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Intuitive Surgical (ISRG) and McKesson (MCK). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Intuitive Surgical (ISRG) has an aggressive beta of 1.46, indicating higher sensitivity to broad-market moves, while McKesson (MCK) is defensive at 0.31 and tends to be less market-sensitive — they sit on opposite ends of the beta spectrum.

Risk profile metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
Volatility (1Y, Annualized)	35.38%	30.21%
Beta (5Y)	1.46	0.31
Max Drawdown (5Y)	-49.90%	-27.17%
Avg. Volume (3M)	2.84M	1.18M

Risk-Adjusted Performance

Risk-Return Positioning

ISRG and MCK are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
Sharpe Ratio (1Y)	-1.02	0.43
Sortino Ratio (1Y)	-1.39	0.70

Profitability

ROE (TTM)

Capital efficiency shows on one side only: Intuitive Surgical (ISRG) earns 17.42% on shareholders’ equity, ranked against its industry; McKesson (MCK) has no ROE this period.

ISRG

Health Care Equipment & Services industry group

17.42%

Max: 53.65%
ISRG: 17.42%
Q3: 13.93%
Median: 3.71%
Q1: -16.92%
Min: -59.21%

MCK

Health Care Equipment & Services industry group

Max: 53.65%
Q3: 13.93%
Median: 3.71%
Q1: -16.92%
Min: -59.21%
MCK: --

Intuitive Surgical (ISRG) vs. McKesson (MCK): MCK does not report ROE, so it has no value marker; ISRG is benchmarked against the Health Care Equipment & Services industry group.

Net Margin (TTM)

Intuitive Surgical (ISRG) at 28.45% retains a top-quartile share of revenue as profit, ahead of McKesson (MCK) at 1.18%, which keeps about the industry-typical share.

ISRG

Health Care Equipment & Services industry group

28.45%

Max: 30.40%
ISRG: 28.45%
Q3: 8.56%
Median: 1.55%
Q1: -9.20%
Min: -34.34%

MCK

Health Care Equipment & Services industry group

1.18%

Max: 30.40%
Q3: 8.56%
Median: 1.55%
MCK: 1.18%
Q1: -9.20%
Min: -34.34%

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their net margin against the Health Care Equipment & Services industry group benchmark.

Operating Margin (TTM)

Intuitive Surgical (ISRG) at 33.75% operates in the top operating margin quartile, ahead of McKesson (MCK) at 2.21%, which runs around its industry’s norm.

ISRG

Health Care Equipment & Services industry group

33.75%

Max: 37.54%
ISRG: 33.75%
Q3: 12.86%
Median: 5.54%
Q1: -4.10%
Min: -25.61%

MCK

Health Care Equipment & Services industry group

2.21%

Max: 37.54%
Q3: 12.86%
Median: 5.54%
MCK: 2.21%
Q1: -4.10%
Min: -25.61%

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their operating margin against the Health Care Equipment & Services industry group benchmark.

Profitability Metrics

Profitability metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
ROE (TTM)	17.42%	--
ROA (TTM)	10.54%	4.99%
Net Margin (TTM)	28.45%	1.18%
Operating Margin (TTM)	33.75%	2.21%
Gross Margin (TTM)	66.77%	3.60%

Growth

Revenue Growth

Intuitive Surgical (ISRG) at 20.51% sits in the top revenue growth quartile, while McKesson (MCK) at 12.36% is closer to the peer norm — faster top-line expansion for ISRG.

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their Revenue Growth across different time periods.

EPS Growth

McKesson (MCK) at 49.22% sits in the top EPS growth quartile, while Intuitive Surgical (ISRG) at 22.59% is closer to the peer norm — faster per-share earnings growth for MCK.

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
Revenue Growth (YoY)	20.51%	12.36%
Revenue Growth (3Y CAGR)	17.39%	13.39%
EPS Growth (YoY)	22.59%	49.22%
EPS Growth (3Y CAGR)	29.19%	15.31%

Financial Strength

Current Ratio (MRQ)

Intuitive Surgical (ISRG) at 6.43 carries current ratio above its industry’s typical mid-range, while McKesson (MCK) at 0.85 runs in the tighter-liquidity quartile — different working-capital profiles, both worth examining.

ISRG

Health Care Equipment & Services industry group

6.43

Max: 7.79
ISRG: 6.43
Q3: 4.32
Median: 2.03
Q1: 1.34
Min: 0.04

MCK

Health Care Equipment & Services industry group

0.85

Max: 7.79
Q3: 4.32
Median: 2.03
Q1: 1.34
MCK: 0.85
Min: 0.04

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their current ratio against the Health Care Equipment & Services industry group benchmark.

Debt / Equity (MRQ)

Neither Intuitive Surgical (ISRG) nor McKesson (MCK) reports a debt-to-equity ratio value for this period, so a direct comparison isn’t possible.

ISRG

Health Care Equipment & Services industry group

Max: 2.02
Q3: 0.99
Median: 0.58
Q1: 0.15
Min: 0.00
ISRG: --

MCK

Health Care Equipment & Services industry group

Max: 2.02
Q3: 0.99
Median: 0.58
Q1: 0.15
Min: 0.00
MCK: --

Intuitive Surgical (ISRG) vs. McKesson (MCK): Neither stock reports debt-to-equity ratio, so the chart shows available benchmark boxes without value markers.

Financial Strength Metrics

Financial strength metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
Current Ratio (MRQ)	6.43	0.85
Debt / Equity (MRQ)	--	--
Net Debt / EBITDA	-2.07	0.70

Dividends

Dividend Yield (TTM)

Intuitive Surgical (ISRG) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile McKesson (MCK) reports a yield of 0.38%, ranking against industry peers normally.

ISRG

Health Care Equipment & Services industry group

0.00%

ISRG: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

MCK

Health Care Equipment & Services industry group

0.38%

MCK: 0.38%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their dividend yield against the Health Care Equipment & Services industry group benchmark.

Dividend Payout Ratio (TTM)

Intuitive Surgical (ISRG) pays no dividend (payout 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile McKesson (MCK) reports a payout of 8.26%, ranking against industry peers normally.

ISRG

Health Care Equipment & Services industry group

0.00%

ISRG: 0.00%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

MCK

Health Care Equipment & Services industry group

8.26%

MCK: 8.26%
Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their payout ratio against the Health Care Equipment & Services industry group benchmark.

Dividend Metrics

Dividend metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
Dividend Yield (TTM)	0.00%	0.38%
Dividend Payout Ratio (TTM)	0.00%	8.26%

Valuation

P/E Ratio (TTM)

Both Intuitive Surgical (ISRG) at 40.47 and McKesson (MCK) at 21.65 land around their industries’ usual P/E ratio levels — neither is getting a clear earnings-multiple discount or premium versus peers.

ISRG

Health Care Equipment & Services industry group

40.47

Max: 73.47
Q3: 45.86
ISRG: 40.47
Median: 30.56
Q1: 21.37
Min: 0.91

MCK

Health Care Equipment & Services industry group

21.65

Max: 73.47
Q3: 45.86
Median: 30.56
MCK: 21.65
Q1: 21.37
Min: 0.91

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their P/E ratio against the Health Care Equipment & Services industry group benchmark.

P/S Ratio (TTM)

McKesson (MCK) at 0.24 sits in the cheaper P/S ratio quartile while Intuitive Surgical (ISRG) at 11.24 prices above its industry range — a wide gap in sales valuation between them.

ISRG

Health Care Equipment & Services industry group

11.24

ISRG: 11.24
Max: 8.58
Q3: 4.23
Median: 2.05
Q1: 1.10
Min: 0.04

MCK

Health Care Equipment & Services industry group

0.24

Max: 8.58
Q3: 4.23
Median: 2.05
Q1: 1.10
MCK: 0.24
Min: 0.04

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their P/S ratio against the Health Care Equipment & Services industry group benchmark.

P/B Ratio (MRQ)

McKesson (MCK) reports a negative P/B ratio of -45.79, meaning negative book equity — the multiple itself is not meaningful for valuation. Meanwhile Intuitive Surgical (ISRG) reports 7.10, ranking against industry peers normally.

ISRG

Health Care Equipment & Services industry group

7.10

Max: 12.13
ISRG: 7.10
Q3: 5.82
Median: 2.96
Q1: 1.56
Min: -2.02

MCK

Health Care Equipment & Services industry group

-45.79

Max: 12.13
Q3: 5.82
Median: 2.96
Q1: 1.56
Min: -2.02
MCK: -45.79

Intuitive Surgical (ISRG) vs. McKesson (MCK): A comparison of their P/B ratio against the Health Care Equipment & Services industry group benchmark.

Valuation Metrics

Valuation metrics for Intuitive Surgical (ISRG) and McKesson (MCK)
Metric	ISRG	MCK
P/E Ratio (TTM)	40.47	21.65
P/S Ratio (TTM)	11.24	0.24
P/B Ratio (MRQ)	7.10	-45.79
Free Cash Flow Yield (TTM)	--	5.83%