INSM vs. NVS: Insmed vs. Novartis Stock Comparison
How do Insmed (INSM) and Novartis (NVS) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.
Company Profile
Insmed (INSM) and Novartis (NVS) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but INSM is classified in Biotechnology while NVS is classified in Pharmaceuticals.
Insmed (INSM) trades as ordinary local shares, while Novartis (NVS) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.
| Profile Item | INSM | NVS |
|---|---|---|
| Name | Insmed Incorporated | Novartis AG Sponsored ADR |
| Country/Region | United States | Switzerland |
| GICS Sector | Health Care | Health Care |
| GICS Industry Group | Pharmaceuticals, Biotechnology & Life Sciences | Pharmaceuticals, Biotechnology & Life Sciences |
| GICS Industry | Biotechnology | Pharmaceuticals |
| GICS Sub-Industry | Biotechnology | Pharmaceuticals |
| Market Capitalization | 25.10 billion USD | 307.00 billion USD |
| Currency | USD | USD |
| Exchange | Nasdaq | NYSE |
| Listing Date | June 1, 2000 | November 7, 1996 |
| Security Type | Common Stock | ADR |
Price Performance
Cumulative Growth
Trailing Returns
Calendar-Year Returns
Performance Metrics
| Metric | INSM | NVS |
|---|---|---|
| Total Return (1Y) | -39.17% | 32.98% |
| Total Return (3Y, Annualized) | 70.17% | 24.72% |
| Total Return (5Y, Annualized) | 28.96% | 18.80% |
Risk Profile
Drawdown History
Return Distribution
Risk Metrics
| Metric | INSM | NVS |
|---|---|---|
| Volatility (1Y, Annualized) | 63.09% | 27.12% |
| Beta (5Y) | 0.80 | 0.41 |
| Max Drawdown (5Y) | -56.54% | -20.42% |
| Avg. Volume (3M) | 2.76M | 2.07M |
Risk-Adjusted Performance
Risk-Return Positioning
Risk-Adjusted Metrics
| Metric | INSM | NVS |
|---|---|---|
| Sharpe Ratio (1Y) | -0.69 | 1.06 |
| Sortino Ratio (1Y) | -1.04 | 1.46 |
Profitability
ROE (TTM)
Insmed (INSM) reports a negative ROE of -72.45%; negative ROE can reflect losses or negative shareholders’ equity, so it is harder to read as capital efficiency. Meanwhile Novartis (NVS) reports 24.33%, ranking against industry peers normally.
INSM
Pharmaceuticals, Biotechnology & Life Sciences industry group
-72.45%
- Max
- 109.18%
- Q3
- 6.23%
- Median
- -26.66%
- Q1
- -64.05%
- INSM
- -72.45%
- Min
- -167.77%
NVS
Pharmaceuticals, Biotechnology & Life Sciences industry group
24.33%
- Max
- 109.18%
- NVS
- 24.33%
- Q3
- 6.23%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
Net Margin (TTM)
Insmed (INSM) reports a negative net margin of -39.85%, usually indicating a net loss over the period. Meanwhile Novartis (NVS) reports 17.49%, ranking against industry peers normally.
INSM
Pharmaceuticals, Biotechnology & Life Sciences industry group
-39.85%
- Max
- 18.05%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
- INSM
- -39.85%
NVS
Pharmaceuticals, Biotechnology & Life Sciences industry group
17.49%
- Max
- 18.05%
- NVS
- 17.49%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
Operating Margin (TTM)
Insmed (INSM) reports a negative operating margin of -15.60%, usually indicating that operating costs exceeded revenue at the operating-income line. Meanwhile Novartis (NVS) reports 34.27%, ranking against industry peers normally.
INSM
Pharmaceuticals, Biotechnology & Life Sciences industry group
-15.60%
- Max
- 83.12%
- Q3
- 14.77%
- Median
- 0.00%
- INSM
- -15.60%
- Q1
- -78.82%
- Min
- -207.40%
NVS
Pharmaceuticals, Biotechnology & Life Sciences industry group
34.27%
- Max
- 83.12%
- NVS
- 34.27%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
Profitability Metrics
| Metric | INSM | NVS |
|---|---|---|
| ROE (TTM) | -72.45% | 24.33% |
| ROA (TTM) | -17.25% | 10.86% |
| Net Margin (TTM) | -39.85% | 17.49% |
| Operating Margin (TTM) | -15.60% | 34.27% |
| Gross Margin (TTM) | 84.40% | 75.21% |
Growth
Revenue Growth
Insmed (INSM) at 66.73% sits in the top revenue growth quartile, while Novartis (NVS) at 9.57% is closer to the peer norm — faster top-line expansion for INSM.
EPS Growth
Only one side can be read here: Novartis (NVS) reports EPS growth of 21.81%, ranked against its industry; Insmed (INSM) has no EPS growth figure this period.
Growth Metrics
| Metric | INSM | NVS |
|---|---|---|
| Revenue Growth (YoY) | 66.73% | 9.57% |
| Revenue Growth (3Y CAGR) | 35.20% | 9.25% |
| EPS Growth (YoY) | -- | 21.81% |
| EPS Growth (3Y CAGR) | -- | 31.14% |
Financial Strength
Current Ratio (MRQ)
Insmed (INSM) at 2.86 keeps current ratio within its industry’s typical mid-range, while Novartis (NVS) at 0.88 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for NVS.
INSM
Pharmaceuticals, Biotechnology & Life Sciences industry group
2.86
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- INSM
- 2.86
- Q1
- 2.47
- Min
- 0.10
NVS
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.88
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- Q1
- 2.47
- NVS
- 0.88
- Min
- 0.10
Debt / Equity (MRQ)
Both Insmed (INSM) at 1.01 and Novartis (NVS) at 1.29 lean more heavily on debt funding than most peers, landing in the higher-leverage quartile of their industries.
INSM
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.01
- Max
- 1.42
- INSM
- 1.01
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
NVS
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.29
- Max
- 1.42
- NVS
- 1.29
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
Financial Strength Metrics
| Metric | INSM | NVS |
|---|---|---|
| Current Ratio (MRQ) | 2.86 | 0.88 |
| Debt / Equity (MRQ) | 1.01 | 1.29 |
| Net Debt / EBITDA | -- | 1.64 |
Dividends
Dividend Yield (TTM)
Insmed (INSM) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Novartis (NVS) reports a yield of 2.88%, ranking against industry peers normally.
INSM
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- INSM
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
NVS
Pharmaceuticals, Biotechnology & Life Sciences industry group
2.88%
- NVS
- 2.88%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Payout Ratio (TTM)
Insmed (INSM) pays no dividend (payout 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Novartis (NVS) reports a payout of 90.46%, ranking against industry peers normally.
INSM
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- INSM
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
NVS
Pharmaceuticals, Biotechnology & Life Sciences industry group
90.46%
- NVS
- 90.46%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Metrics
| Metric | INSM | NVS |
|---|---|---|
| Dividend Yield (TTM) | 0.00% | 2.88% |
| Dividend Payout Ratio (TTM) | 0.00% | 90.46% |
Valuation
P/E Ratio (TTM)
An earnings multiple is available for just one side: Novartis (NVS) trades at 31.02 times trailing earnings, ranked against its peers, while Insmed (INSM) has no P/E ratio this period.
INSM
Pharmaceuticals, Biotechnology & Life Sciences industry group
--
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- Q1
- 13.30
- Min
- 0.07
- INSM
- --
NVS
Pharmaceuticals, Biotechnology & Life Sciences industry group
31.02
- Max
- 85.34
- Q3
- 43.46
- NVS
- 31.02
- Median
- 26.69
- Q1
- 13.30
- Min
- 0.07
P/S Ratio (TTM)
On P/S ratio, both Insmed (INSM) at 16.52 and Novartis (NVS) at 5.35 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.
INSM
Pharmaceuticals, Biotechnology & Life Sciences industry group
16.52
- Max
- 58.18
- Q3
- 25.77
- INSM
- 16.52
- Median
- 7.30
- Q1
- 3.01
- Min
- 0.01
NVS
Pharmaceuticals, Biotechnology & Life Sciences industry group
5.35
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- NVS
- 5.35
- Q1
- 3.01
- Min
- 0.01
P/B Ratio (MRQ)
Both look rich against book: Novartis (NVS) at 8.25 sits in the upper P/B ratio quartile, and Insmed (INSM) at 34.55 prices even higher, above its industry range.
INSM
Pharmaceuticals, Biotechnology & Life Sciences industry group
34.55
- INSM
- 34.55
- Max
- 13.53
- Q3
- 6.54
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
NVS
Pharmaceuticals, Biotechnology & Life Sciences industry group
8.25
- Max
- 13.53
- NVS
- 8.25
- Q3
- 6.54
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
Valuation Metrics
| Metric | INSM | NVS |
|---|---|---|
| P/E Ratio (TTM) | -- | 31.02 |
| P/S Ratio (TTM) | 16.52 | 5.35 |
| P/B Ratio (MRQ) | 34.55 | 8.25 |
| Free Cash Flow Yield (TTM) | -1.82% | 3.67% |