EXEL vs. KRYS: A Head-to-Head Stock Comparison

Updated on November 22, 2025

Here’s a clear look at EXEL and KRYS, comparing key factors like historical performance, profitability, financial strength, growth, dividend, and valuation.

Company Profile

Symbol	EXEL	KRYS
Company Name	Exelixis, Inc.	Krystal Biotech, Inc.
Country	United States	United States
GICS Sector	Health Care	Health Care
GICS Industry	Biotechnology	Biotechnology
Market Capitalization	11.57 billion USD	6.13 billion USD
Exchange	NasdaqGS	NasdaqGS
Listing Date	April 17, 2000	September 20, 2017
Security Type	Common Stock	Common Stock

Historical Performance

This chart compares the performance of EXEL and KRYS by tracking the growth of an initial $10,000 investment in each. Use the tabs to select the desired time period. Data is adjusted for dividends and splits.

EXEL vs. KRYS: Growth of a $10,000 investment over the past one year.

Historical Performance at a Glance

Symbol	EXEL	KRYS
5-Day Price Return	0.58%	3.32%
13-Week Price Return	8.72%	37.19%
26-Week Price Return	12.72%	53.24%
52-Week Price Return	18.36%	11.91%
Month-to-Date Return	7.71%	4.38%
Year-to-Date Return	25.08%	31.60%
10-Day Avg. Volume	3.18M	0.39M
3-Month Avg. Volume	2.91M	0.34M
3-Month Volatility	39.61%	36.80%
Beta	0.39	0.48

Profitability

Return on Equity (TTM)

EXEL

31.64%

Biotechnology Industry

Max: 96.19%
Q3: 12.45%
Median: -16.39%
Q1: -47.43%
Min: -131.19%

In the upper quartile for the Biotechnology industry, EXEL’s Return on Equity of 31.64% signals a highly effective use of shareholder capital to drive profitability compared to most of its peers.

KRYS

19.36%

Biotechnology Industry

Max: 96.19%
Q3: 12.45%
Median: -16.39%
Q1: -47.43%
Min: -131.19%

In the upper quartile for the Biotechnology industry, KRYS’s Return on Equity of 19.36% signals a highly effective use of shareholder capital to drive profitability compared to most of its peers.

EXEL vs. KRYS: A comparison of their Return on Equity (TTM) against the Biotechnology industry benchmark.

Net Profit Margin (TTM)

EXEL

29.63%

Biotechnology Industry

Max: 84.13%
Q3: 19.34%
Median: -1.39%
Q1: -117.64%
Min: -296.77%

A Net Profit Margin of 29.63% places EXEL in the upper quartile for the Biotechnology industry, signifying strong profitability and more effective cost management than most of its peers.

KRYS

53.30%

Biotechnology Industry

Max: 84.13%
Q3: 19.34%
Median: -1.39%
Q1: -117.64%
Min: -296.77%

A Net Profit Margin of 53.30% places KRYS in the upper quartile for the Biotechnology industry, signifying strong profitability and more effective cost management than most of its peers.

EXEL vs. KRYS: A comparison of their Net Profit Margin (TTM) against the Biotechnology industry benchmark.

Operating Profit Margin (TTM)

EXEL

34.97%

Biotechnology Industry

Max: 78.85%
Q3: 20.86%
Median: 0.51%
Q1: -128.29%
Min: -315.84%

An Operating Profit Margin of 34.97% places EXEL in the upper quartile for the Biotechnology industry. This signals a strong ability to translate revenue into operating profit, outperforming most of its competitors in core business efficiency.

KRYS

42.40%

Biotechnology Industry

Max: 78.85%
Q3: 20.86%
Median: 0.51%
Q1: -128.29%
Min: -315.84%

An Operating Profit Margin of 42.40% places KRYS in the upper quartile for the Biotechnology industry. This signals a strong ability to translate revenue into operating profit, outperforming most of its competitors in core business efficiency.

EXEL vs. KRYS: A comparison of their Operating Profit Margin (TTM) against the Biotechnology industry benchmark.

Profitability at a Glance

Symbol	EXEL	KRYS
Return on Equity (TTM)	31.64%	19.36%
Return on Assets (TTM)	24.03%	17.65%
Net Profit Margin (TTM)	29.63%	53.30%
Operating Profit Margin (TTM)	34.97%	42.40%
Gross Profit Margin (TTM)	96.63%	94.26%

Financial Strength

Current Ratio (MRQ)

EXEL

3.75

Biotechnology Industry

Max: 15.83
Q3: 7.97
Median: 4.06
Q1: 2.64
Min: 0.72

EXEL’s Current Ratio of 3.75 aligns with the median group of the Biotechnology industry, indicating that its short-term liquidity is in line with its sector peers.

KRYS

10.14

Biotechnology Industry

Max: 15.83
Q3: 7.97
Median: 4.06
Q1: 2.64
Min: 0.72

KRYS’s Current Ratio of 10.14 is in the upper quartile for the Biotechnology industry. This signifies a strong liquidity position, suggesting the company is well-equipped to cover its immediate liabilities compared to its peers.

EXEL vs. KRYS: A comparison of their Current Ratio (MRQ) against the Biotechnology industry benchmark.

Debt-to-Equity Ratio (MRQ)

EXEL

0.00

Biotechnology Industry

Max: 1.27
Q3: 0.62
Median: 0.13
Q1: 0.00
Min: 0.00

EXEL’s Debt-to-Equity Ratio of 0.00 is typical for the Biotechnology industry, indicating its use of leverage is in line with the sector norm. This suggests a balanced approach to its capital structure.

KRYS

0.00

Biotechnology Industry

Max: 1.27
Q3: 0.62
Median: 0.13
Q1: 0.00
Min: 0.00

KRYS’s Debt-to-Equity Ratio of 0.00 is typical for the Biotechnology industry, indicating its use of leverage is in line with the sector norm. This suggests a balanced approach to its capital structure.

EXEL vs. KRYS: A comparison of their Debt-to-Equity Ratio (MRQ) against the Biotechnology industry benchmark.

Interest Coverage Ratio (TTM)

EXEL

42.74

Biotechnology Industry

Max: 72.37
Q3: 1.71
Median: -15.18
Q1: -65.75
Min: -166.46

EXEL’s Interest Coverage Ratio of 42.74 is in the upper quartile for the Biotechnology industry, signifying a strong and healthy capacity to meet its interest payments from operating profits.

KRYS

-52.52

Biotechnology Industry

Max: 72.37
Q3: 1.71
Median: -15.18
Q1: -65.75
Min: -166.46

KRYS has a negative Interest Coverage Ratio of -52.52. This indicates that its earnings were insufficient to cover even its operational costs, let alone its interest payments, signaling significant financial distress.

EXEL vs. KRYS: A comparison of their Interest Coverage Ratio (TTM) against the Biotechnology industry benchmark.

Financial Strength at a Glance

Symbol	EXEL	KRYS
Current Ratio (MRQ)	3.75	10.14
Quick Ratio (MRQ)	3.47	9.43
Debt-to-Equity Ratio (MRQ)	0.00	0.00
Interest Coverage Ratio (TTM)	42.74	-52.52

Growth

Revenue Growth

EXEL vs. KRYS: A side-by-side comparison of their Revenue Growth for the MRQ (YoY), TTM (YoY), 3-Year CAGR, and 5-Year CAGR periods.

EPS Growth

EXEL vs. KRYS: A side-by-side comparison of their EPS Growth for the MRQ (YoY), TTM (YoY), 3-Year CAGR, and 5-Year CAGR periods.

Dividend

Dividend Yield (TTM)

EXEL

0.00%

Biotechnology Industry

Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

EXEL currently does not pay a dividend, resulting in a yield of 0%. This is a common strategy for growth-focused companies that prioritize reinvesting earnings, though it may be less typical in mature, income-oriented sectors.

KRYS

0.00%

Biotechnology Industry

Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

KRYS currently does not pay a dividend, resulting in a yield of 0%. This is a common strategy for growth-focused companies that prioritize reinvesting earnings, though it may be less typical in mature, income-oriented sectors.

EXEL vs. KRYS: A comparison of their Dividend Yield (TTM) against the Biotechnology industry benchmark.

Dividend Payout Ratio (TTM)

EXEL

0.00%

Biotechnology Industry

Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

EXEL has a Dividend Payout Ratio of 0%, indicating it does not currently pay a dividend. This is a common strategy for growth-oriented companies that reinvest all profits back into the business.

KRYS

0.00%

Biotechnology Industry

Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

KRYS has a Dividend Payout Ratio of 0%, indicating it does not currently pay a dividend. This is a common strategy for growth-oriented companies that reinvest all profits back into the business.

EXEL vs. KRYS: A comparison of their Dividend Payout Ratio (TTM) against the Biotechnology industry benchmark.

Dividend at a Glance

Symbol	EXEL	KRYS
Dividend Yield (TTM)	0.00%	0.00%
Dividend Payout Ratio (TTM)	0.00%	0.00%

Valuation

Price-to-Earnings Ratio (TTM)

EXEL

16.96

Biotechnology Industry

Max: 115.91
Q3: 56.76
Median: 21.80
Q1: 15.79
Min: 4.51

EXEL’s P/E Ratio of 16.96 is within the middle range for the Biotechnology industry. This suggests its valuation is in line with the sector average, representing neither a significant premium nor a discount compared to its peers.

KRYS

30.47

Biotechnology Industry

Max: 115.91
Q3: 56.76
Median: 21.80
Q1: 15.79
Min: 4.51

KRYS’s P/E Ratio of 30.47 is within the middle range for the Biotechnology industry. This suggests its valuation is in line with the sector average, representing neither a significant premium nor a discount compared to its peers.

EXEL vs. KRYS: A comparison of their Price-to-Earnings Ratio (TTM) against the Biotechnology industry benchmark.

Price-to-Sales Ratio (TTM)

EXEL

5.02

Biotechnology Industry

Max: 58.56
Q3: 29.31
Median: 8.30
Q1: 4.89
Min: 0.86

EXEL’s P/S Ratio of 5.02 aligns with the market consensus for the Biotechnology industry. This suggests its valuation, based on sales, is seen as standard and is on par with its competitors.

KRYS

16.24

Biotechnology Industry

Max: 58.56
Q3: 29.31
Median: 8.30
Q1: 4.89
Min: 0.86

KRYS’s P/S Ratio of 16.24 aligns with the market consensus for the Biotechnology industry. This suggests its valuation, based on sales, is seen as standard and is on par with its competitors.

EXEL vs. KRYS: A comparison of their Price-to-Sales Ratio (TTM) against the Biotechnology industry benchmark.

Price-to-Book Ratio (MRQ)

EXEL

4.99

Biotechnology Industry

Max: 17.92
Q3: 10.38
Median: 4.78
Q1: 2.85
Min: 0.78

EXEL’s P/B Ratio of 4.99 is within the conventional range for the Biotechnology industry. This shows a balanced market view, where the stock’s price is neither at a significant premium nor a discount to the book value of its peers.

KRYS

4.49

Biotechnology Industry

Max: 17.92
Q3: 10.38
Median: 4.78
Q1: 2.85
Min: 0.78

KRYS’s P/B Ratio of 4.49 is within the conventional range for the Biotechnology industry. This shows a balanced market view, where the stock’s price is neither at a significant premium nor a discount to the book value of its peers.

EXEL vs. KRYS: A comparison of their Price-to-Book Ratio (MRQ) against the Biotechnology industry benchmark.

Valuation at a Glance

Symbol	EXEL	KRYS
Price-to-Earnings Ratio (TTM)	16.96	30.47
Price-to-Sales Ratio (TTM)	5.02	16.24
Price-to-Book Ratio (MRQ)	4.99	4.49
Price-to-Free Cash Flow Ratio (TTM)	14.74	36.60