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AZN vs. NVO: AstraZeneca vs. Novo Nordisk Stock Comparison

How do AstraZeneca (AZN) and Novo Nordisk (NVO) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

AstraZeneca (AZN) and Novo Nordisk (NVO) are both classified in the Pharmaceuticals sub-industry within the broader Pharmaceuticals industry, placing them in the closest GICS peer bucket.

Both AstraZeneca (AZN) and Novo Nordisk (NVO) trade as ADRs — their core financials are comparable, but keep FX, depositary-program fees, and dividend withholding in view for each.

Company profile comparison for AstraZeneca (AZN) and Novo Nordisk (NVO)
Profile ItemAZNNVO
NameAstraZeneca PLC American Depositary SharesNovo Nordisk A/S Sponsored ADR
Country/RegionUnited KingdomDenmark
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryPharmaceuticalsPharmaceuticals
GICS Sub-IndustryPharmaceuticalsPharmaceuticals
Market Capitalization262.63 billion USD218.40 billion USD
CurrencyUSDUSD
ExchangeNasdaqNYSE
Listing DateMay 12, 1993April 30, 1981
Security TypeADRADR

Price Performance

Cumulative Growth

AZN
NVO
GSPC
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AstraZeneca (AZN) vs. Novo Nordisk (NVO), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for AstraZeneca (AZN) and Novo Nordisk (NVO). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for AstraZeneca (AZN) and Novo Nordisk (NVO). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for AstraZeneca (AZN) and Novo Nordisk (NVO)
MetricAZNNVO
Total Return (1Y)25.36%-20.26%
Total Return (3Y, Annualized)9.02%-13.59%
Total Return (5Y, Annualized)10.24%4.36%

Risk Profile

Drawdown History

AZN
NVO
GSPC
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AstraZeneca (AZN) vs. Novo Nordisk (NVO), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for AstraZeneca (AZN) and Novo Nordisk (NVO). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for AstraZeneca (AZN) and Novo Nordisk (NVO)
MetricAZNNVO
Volatility (1Y, Annualized)28.24%51.79%
Beta (5Y)0.260.75
Max Drawdown (5Y)-27.87%-74.70%
Avg. Volume (3M)2.24M13.81M

Risk-Adjusted Performance

Risk-Return Positioning

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AZN and NVO are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for AstraZeneca (AZN) and Novo Nordisk (NVO)
MetricAZNNVO
Sharpe Ratio (1Y)0.76-0.47
Sortino Ratio (1Y)1.21-0.61

Profitability

ROE (TTM)

Both AstraZeneca (AZN) at 23.48% and Novo Nordisk (NVO) at 71.40% sit in the top peer quartile for ROE, suggesting each generates more profit from shareholders’ equity than typical industry peers.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

23.48%

Max
99.40%
AZN
23.48%
Q3
2.50%
Median
-31.42%
Q1
-62.21%
Min
-157.07%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

71.40%

Max
99.40%
NVO
71.40%
Q3
2.50%
Median
-31.42%
Q1
-62.21%
Min
-157.07%
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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Both AstraZeneca (AZN) at 17.19% and Novo Nordisk (NVO) at 37.21% keep an unusually large share of revenue as bottom-line profit — each net margin clears its industry’s benchmark range.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

17.19%

AZN
17.19%
Max
11.75%
Q3
2.69%
Median
0.00%
Q1
-3.38%
Min
-11.53%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

37.21%

NVO
37.21%
Max
11.75%
Q3
2.69%
Median
0.00%
Q1
-3.38%
Min
-11.53%
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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both AstraZeneca (AZN) at 27.94% and Novo Nordisk (NVO) at 61.57% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

27.94%

Max
100.30%
AZN
27.94%
Q3
4.66%
Median
0.00%
Q1
-121.08%
Min
-309.54%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

61.57%

Max
100.30%
NVO
61.57%
Q3
4.66%
Median
0.00%
Q1
-121.08%
Min
-309.54%
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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for AstraZeneca (AZN) and Novo Nordisk (NVO)
MetricAZNNVO
ROE (TTM)23.48%71.40%
ROA (TTM)8.49%19.25%
Net Margin (TTM)17.19%37.21%
Operating Margin (TTM)27.94%61.57%
Gross Margin (TTM)81.51%83.20%

Growth

Revenue Growth

Both AstraZeneca (AZN) at 8.63% and Novo Nordisk (NVO) at 6.43% land near their industries' usual revenue growth ranges, so top-line momentum looks broadly in line with peers on both sides.

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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their Revenue Growth across different time periods.

EPS Growth

Both AstraZeneca (AZN) at 45.33% and Novo Nordisk (NVO) at 1.77% land near their industries' usual EPS growth ranges, so bottom-line momentum looks broadly in line with peers on both sides.

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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for AstraZeneca (AZN) and Novo Nordisk (NVO)
MetricAZNNVO
Revenue Growth (YoY)8.63%6.43%
Revenue Growth (3Y CAGR)9.82%20.43%
EPS Growth (YoY)45.33%1.77%
EPS Growth (3Y CAGR)45.80%23.52%

Financial Strength

Current Ratio (MRQ)

Both AstraZeneca (AZN) at 0.91 and Novo Nordisk (NVO) at 0.79 run current ratio in the tighter-liquidity quartile of industry peers, leaving thinner cushions against current liabilities than typical competitors.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.91

Max
26.16
Q3
12.33
Median
5.81
Q1
2.71
AZN
0.91
Min
0.28

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.79

Max
26.16
Q3
12.33
Median
5.81
Q1
2.71
NVO
0.79
Min
0.28
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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Both AstraZeneca (AZN) at 0.72 and Novo Nordisk (NVO) at 0.72 lean more heavily on debt funding than most peers, landing in the higher-leverage quartile of their industries.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.72

Max
1.60
AZN
0.72
Q3
0.68
Median
0.15
Q1
0.02
Min
0.00

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.72

Max
1.60
NVO
0.72
Q3
0.68
Median
0.15
Q1
0.02
Min
0.00
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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for AstraZeneca (AZN) and Novo Nordisk (NVO)
MetricAZNNVO
Current Ratio (MRQ)0.910.79
Debt / Equity (MRQ)0.720.72
Net Debt / EBITDA1.320.72

Dividends

Dividend Yield (TTM)

Both AstraZeneca (AZN) at 1.95% and Novo Nordisk (NVO) at 23.58% yield above their industries’ entire benchmark ranges — high enough that dividend safety, not income, becomes the first question.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.95%

AZN
1.95%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

23.58%

NVO
23.58%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Both AstraZeneca (AZN) at 47.70% and Novo Nordisk (NVO) at 42.59% pay out more of their earnings than any of their industry peers — the thinnest cover in their groups, so dividend headroom deserves attention.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

47.70%

AZN
47.70%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

42.59%

NVO
42.59%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for AstraZeneca (AZN) and Novo Nordisk (NVO)
MetricAZNNVO
Dividend Yield (TTM)1.95%23.58%
Dividend Payout Ratio (TTM)47.70%42.59%

Valuation

P/E Ratio (TTM)

Novo Nordisk (NVO) at 11.90 sits in the cheaper P/E ratio quartile, while AstraZeneca (AZN) at 24.76 is closer to its industry’s usual earnings multiple — a discount for NVO, though growth and earnings durability still matter.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

24.76

Max
79.93
Q3
47.39
Median
25.31
AZN
24.76
Q1
15.26
Min
2.05

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

11.90

Max
79.93
Q3
47.39
Median
25.31
Q1
15.26
NVO
11.90
Min
2.05
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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

Novo Nordisk (NVO) at 0.67 sits in the cheaper P/S ratio quartile while AstraZeneca (AZN) at 4.35 prices around its industry’s middle — NVO costs less per dollar of sales, though read it alongside growth and margins.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.35

Max
63.16
Q3
28.29
Median
8.07
AZN
4.35
Q1
3.52
Min
0.01

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.67

Max
63.16
Q3
28.29
Median
8.07
Q1
3.52
NVO
0.67
Min
0.01
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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

On P/B ratio, both AstraZeneca (AZN) at 5.54 and Novo Nordisk (NVO) at 7.08 are valued close to their industries’ norm against book — neither stands out from peers.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.54

Max
16.09
Q3
7.48
AZN
5.54
Median
3.80
Q1
1.72
Min
-5.70

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.08

Max
16.09
Q3
7.48
NVO
7.08
Median
3.80
Q1
1.72
Min
-5.70
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AstraZeneca (AZN) vs. Novo Nordisk (NVO): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for AstraZeneca (AZN) and Novo Nordisk (NVO)
MetricAZNNVO
P/E Ratio (TTM)24.7611.90
P/S Ratio (TTM)4.350.67
P/B Ratio (MRQ)5.547.08
Free Cash Flow Yield (TTM)2.50%-5.51%