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AZN vs. NBIX: AstraZeneca vs. Neurocrine Biosciences Stock Comparison

How do AstraZeneca (AZN) and Neurocrine Biosciences (NBIX) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

AstraZeneca (AZN) and Neurocrine Biosciences (NBIX) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but AZN is classified in Pharmaceuticals while NBIX is classified in Biotechnology.

Neurocrine Biosciences (NBIX) trades as ordinary local shares, while AstraZeneca (AZN) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.

Company profile comparison for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX)
Profile ItemAZNNBIX
NameAstraZeneca PLC American Depositary SharesNeurocrine Biosciences, Inc.
Country/RegionUnited KingdomUnited States
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryPharmaceuticalsBiotechnology
GICS Sub-IndustryPharmaceuticalsBiotechnology
Market Capitalization289.14 billion USD16.66 billion USD
CurrencyUSDUSD
ExchangeNasdaqNasdaq
Listing DateMay 12, 1993May 23, 1996
Security TypeADRCommon Stock

Price Performance

Cumulative Growth

AZN
NBIX
GSPC
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX)
MetricAZNNBIX
Total Return (1Y)12.64%9.40%
Total Return (3Y, Annualized)15.75%14.12%
Total Return (5Y, Annualized)10.63%12.61%

Risk Profile

Drawdown History

AZN
NBIX
GSPC
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX)
MetricAZNNBIX
Volatility (1Y, Annualized)28.21%35.05%
Beta (5Y)0.220.29
Max Drawdown (5Y)-27.87%-42.89%
Avg. Volume (3M)3.14M1.31M

Risk-Adjusted Performance

Risk-Return Positioning

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AZN and NBIX are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX)
MetricAZNNBIX
Sharpe Ratio (1Y)0.300.15
Sortino Ratio (1Y)0.440.22

Profitability

ROE (TTM)

Both AstraZeneca (AZN) at 22.57% and Neurocrine Biosciences (NBIX) at 20.42% sit in the top peer quartile for ROE, suggesting each generates more profit from shareholders’ equity than typical industry peers.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

22.57%

Max
109.18%
AZN
22.57%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

NBIX

Pharmaceuticals, Biotechnology & Life Sciences industry group

20.42%

Max
109.18%
NBIX
20.42%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Neurocrine Biosciences (NBIX) at 18.98% keeps the most of each sales dollar — above its industry’s net margin range — and AstraZeneca (AZN) at 17.68% also retains a top-quartile share.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

17.68%

Max
18.05%
AZN
17.68%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%

NBIX

Pharmaceuticals, Biotechnology & Life Sciences industry group

18.98%

NBIX
18.98%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both AstraZeneca (AZN) at 29.57% and Neurocrine Biosciences (NBIX) at 31.98% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

29.57%

Max
83.12%
AZN
29.57%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

NBIX

Pharmaceuticals, Biotechnology & Life Sciences industry group

31.98%

Max
83.12%
NBIX
31.98%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX)
MetricAZNNBIX
ROE (TTM)22.57%20.42%
ROA (TTM)8.59%12.45%
Net Margin (TTM)17.68%18.98%
Operating Margin (TTM)29.57%31.98%
Gross Margin (TTM)81.78%64.67%

Growth

Revenue Growth

Both AstraZeneca (AZN) at 8.63% and Neurocrine Biosciences (NBIX) at 21.45% land near their industries' usual revenue growth ranges, so top-line momentum looks broadly in line with peers on both sides.

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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their Revenue Growth across different time periods.

EPS Growth

Both AstraZeneca (AZN) at 45.33% and Neurocrine Biosciences (NBIX) at 41.95% land near their industries' usual EPS growth ranges, so bottom-line momentum looks broadly in line with peers on both sides.

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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX)
MetricAZNNBIX
Revenue Growth (YoY)8.63%21.45%
Revenue Growth (3Y CAGR)9.82%24.32%
EPS Growth (YoY)45.33%41.95%
EPS Growth (3Y CAGR)45.80%44.12%

Financial Strength

Current Ratio (MRQ)

Both AstraZeneca (AZN) at 1.01 and Neurocrine Biosciences (NBIX) at 2.04 run current ratio in the tighter-liquidity quartile of industry peers, leaving thinner cushions against current liabilities than typical competitors.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.01

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
AZN
1.01
Min
0.10

NBIX

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.04

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
NBIX
2.04
Min
0.10
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Neurocrine Biosciences (NBIX) at 0.12 carries an industry-typical debt-to-equity mix, while AstraZeneca (AZN) at 0.66 uses more debt funding than most peers.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.66

Max
1.42
AZN
0.66
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00

NBIX

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.12

Max
1.42
Q3
0.65
Median
0.15
NBIX
0.12
Q1
0.02
Min
0.00
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX)
MetricAZNNBIX
Current Ratio (MRQ)1.012.04
Debt / Equity (MRQ)0.660.12
Net Debt / EBITDA1.23-0.27

Dividends

Dividend Yield (TTM)

Neurocrine Biosciences (NBIX) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile AstraZeneca (AZN) reports a yield of 1.73%, ranking against industry peers normally.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.73%

AZN
1.73%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

NBIX

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

NBIX
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Neurocrine Biosciences (NBIX) pays no dividend (payout 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile AstraZeneca (AZN) reports a payout of 45.38%, ranking against industry peers normally.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

45.38%

AZN
45.38%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

NBIX

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

NBIX
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX)
MetricAZNNBIX
Dividend Yield (TTM)1.73%0.00%
Dividend Payout Ratio (TTM)45.38%0.00%

Valuation

P/E Ratio (TTM)

Both AstraZeneca (AZN) at 26.37 and Neurocrine Biosciences (NBIX) at 24.43 land around their industries’ usual P/E ratio levels — neither is getting a clear earnings-multiple discount or premium versus peers.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

26.37

Max
85.34
Q3
43.46
Median
26.69
AZN
26.37
Q1
13.30
Min
0.07

NBIX

Pharmaceuticals, Biotechnology & Life Sciences industry group

24.43

Max
85.34
Q3
43.46
Median
26.69
NBIX
24.43
Q1
13.30
Min
0.07
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

On P/S ratio, both AstraZeneca (AZN) at 4.63 and Neurocrine Biosciences (NBIX) at 4.50 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.63

Max
58.18
Q3
25.77
Median
7.30
AZN
4.63
Q1
3.01
Min
0.01

NBIX

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.50

Max
58.18
Q3
25.77
Median
7.30
NBIX
4.50
Q1
3.01
Min
0.01
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

On P/B ratio, both AstraZeneca (AZN) at 5.59 and Neurocrine Biosciences (NBIX) at 4.30 are valued close to their industries’ norm against book — neither stands out from peers.

AZN

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.59

Max
13.53
Q3
6.54
AZN
5.59
Median
3.25
Q1
1.69
Min
-5.59

NBIX

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.30

Max
13.53
Q3
6.54
NBIX
4.30
Median
3.25
Q1
1.69
Min
-5.59
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AstraZeneca (AZN) vs. Neurocrine Biosciences (NBIX): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for AstraZeneca (AZN) and Neurocrine Biosciences (NBIX)
MetricAZNNBIX
P/E Ratio (TTM)26.3724.43
P/S Ratio (TTM)4.634.50
P/B Ratio (MRQ)5.594.30
Free Cash Flow Yield (TTM)1.95%6.11%