AZN vs. BNTX: AstraZeneca vs. BioNTech Stock Comparison
How do AstraZeneca (AZN) and BioNTech (BNTX) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.
Company Profile
AstraZeneca (AZN) and BioNTech (BNTX) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but AZN is classified in Pharmaceuticals while BNTX is classified in Biotechnology.
Both AstraZeneca (AZN) and BioNTech (BNTX) trade as ADRs — their core financials are comparable, but keep FX, depositary-program fees, and dividend withholding in view for each.
| Profile Item | AZN | BNTX |
|---|---|---|
| Name | AstraZeneca PLC American Depositary Shares | BioNTech SE American Depositary Share |
| Country/Region | United Kingdom | Germany |
| GICS Sector | Health Care | Health Care |
| GICS Industry Group | Pharmaceuticals, Biotechnology & Life Sciences | Pharmaceuticals, Biotechnology & Life Sciences |
| GICS Industry | Pharmaceuticals | Biotechnology |
| GICS Sub-Industry | Pharmaceuticals | Biotechnology |
| Market Capitalization | 289.14 billion USD | 21.70 billion USD |
| Currency | USD | USD |
| Exchange | Nasdaq | Nasdaq |
| Listing Date | May 12, 1993 | October 10, 2019 |
| Security Type | ADR | ADR |
Price Performance
Cumulative Growth
Trailing Returns
Calendar-Year Returns
Performance Metrics
| Metric | AZN | BNTX |
|---|---|---|
| Total Return (1Y) | 12.64% | -14.78% |
| Total Return (3Y, Annualized) | 15.75% | -3.99% |
| Total Return (5Y, Annualized) | 10.63% | -17.02% |
Risk Profile
Drawdown History
Return Distribution
Risk Metrics
BioNTech (BNTX) has an aggressive beta of 1.30, indicating higher sensitivity to broad-market moves, while AstraZeneca (AZN) is defensive at 0.22 and tends to be less market-sensitive — they sit on opposite ends of the beta spectrum.
| Metric | AZN | BNTX |
|---|---|---|
| Volatility (1Y, Annualized) | 28.21% | 47.44% |
| Beta (5Y) | 0.22 | 1.30 |
| Max Drawdown (5Y) | -27.87% | -78.10% |
| Avg. Volume (3M) | 3.14M | 1.21M |
Risk-Adjusted Performance
Risk-Return Positioning
Risk-Adjusted Metrics
| Metric | AZN | BNTX |
|---|---|---|
| Sharpe Ratio (1Y) | 0.30 | -0.40 |
| Sortino Ratio (1Y) | 0.44 | -0.59 |
Profitability
ROE (TTM)
BioNTech (BNTX) reports a negative ROE of -8.14%; negative ROE can reflect losses or negative shareholders’ equity, so it is harder to read as capital efficiency. Meanwhile AstraZeneca (AZN) reports 22.57%, ranking against industry peers normally.
AZN
Pharmaceuticals, Biotechnology & Life Sciences industry group
22.57%
- Max
- 109.18%
- AZN
- 22.57%
- Q3
- 6.23%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
BNTX
Pharmaceuticals, Biotechnology & Life Sciences industry group
-8.14%
- Max
- 109.18%
- Q3
- 6.23%
- BNTX
- -8.14%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
Net Margin (TTM)
BioNTech (BNTX) reports a negative net margin of -60.87%, usually indicating a net loss over the period. Meanwhile AstraZeneca (AZN) reports 17.68%, ranking against industry peers normally.
AZN
Pharmaceuticals, Biotechnology & Life Sciences industry group
17.68%
- Max
- 18.05%
- AZN
- 17.68%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
BNTX
Pharmaceuticals, Biotechnology & Life Sciences industry group
-60.87%
- Max
- 18.05%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
- BNTX
- -60.87%
Operating Margin (TTM)
Both AstraZeneca (AZN) at 29.57% and BioNTech (BNTX) at 30.28% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.
AZN
Pharmaceuticals, Biotechnology & Life Sciences industry group
29.57%
- Max
- 83.12%
- AZN
- 29.57%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
BNTX
Pharmaceuticals, Biotechnology & Life Sciences industry group
30.28%
- Max
- 83.12%
- BNTX
- 30.28%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
Profitability Metrics
| Metric | AZN | BNTX |
|---|---|---|
| ROE (TTM) | 22.57% | -8.14% |
| ROA (TTM) | 8.59% | -4.04% |
| Net Margin (TTM) | 17.68% | -60.87% |
| Operating Margin (TTM) | 29.57% | 30.28% |
| Gross Margin (TTM) | 81.78% | 76.73% |
Growth
Revenue Growth
Both AstraZeneca (AZN) at 8.63% and BioNTech (BNTX) at 4.32% land near their industries' usual revenue growth ranges, so top-line momentum looks broadly in line with peers on both sides.
EPS Growth
Only one side can be read here: AstraZeneca (AZN) reports EPS growth of 45.33%, ranked against its industry; BioNTech (BNTX) has no EPS growth figure this period.
Growth Metrics
| Metric | AZN | BNTX |
|---|---|---|
| Revenue Growth (YoY) | 8.63% | 4.32% |
| Revenue Growth (3Y CAGR) | 9.82% | -45.06% |
| EPS Growth (YoY) | 45.33% | -- |
| EPS Growth (3Y CAGR) | 45.80% | -- |
Financial Strength
Current Ratio (MRQ)
BioNTech (BNTX) at 8.55 keeps current ratio within its industry’s typical mid-range, while AstraZeneca (AZN) at 1.01 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for AZN.
AZN
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.01
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- Q1
- 2.47
- AZN
- 1.01
- Min
- 0.10
BNTX
Pharmaceuticals, Biotechnology & Life Sciences industry group
8.55
- Max
- 25.13
- Q3
- 12.13
- BNTX
- 8.55
- Median
- 5.52
- Q1
- 2.47
- Min
- 0.10
Debt / Equity (MRQ)
BioNTech (BNTX) at 0.02 keeps leverage in the lower quartile, while AstraZeneca (AZN) at 0.66 sits in the higher-leverage quartile.
AZN
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.66
- Max
- 1.42
- AZN
- 0.66
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
BNTX
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.02
- Max
- 1.42
- Q3
- 0.65
- Median
- 0.15
- Q1
- 0.02
- BNTX
- 0.02
- Min
- 0.00
Financial Strength Metrics
| Metric | AZN | BNTX |
|---|---|---|
| Current Ratio (MRQ) | 1.01 | 8.55 |
| Debt / Equity (MRQ) | 0.66 | 0.02 |
| Net Debt / EBITDA | 1.23 | -- |
Dividends
Dividend Yield (TTM)
BioNTech (BNTX) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile AstraZeneca (AZN) reports a yield of 1.73%, ranking against industry peers normally.
AZN
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.73%
- AZN
- 1.73%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
BNTX
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- BNTX
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Payout Ratio (TTM)
BioNTech (BNTX) pays no dividend (payout 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile AstraZeneca (AZN) reports a payout of 45.38%, ranking against industry peers normally.
AZN
Pharmaceuticals, Biotechnology & Life Sciences industry group
45.38%
- AZN
- 45.38%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
BNTX
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- BNTX
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Metrics
| Metric | AZN | BNTX |
|---|---|---|
| Dividend Yield (TTM) | 1.73% | 0.00% |
| Dividend Payout Ratio (TTM) | 45.38% | 0.00% |
Valuation
P/E Ratio (TTM)
An earnings multiple is available for just one side: AstraZeneca (AZN) trades at 26.37 times trailing earnings, ranked against its peers, while BioNTech (BNTX) has no P/E ratio this period.
AZN
Pharmaceuticals, Biotechnology & Life Sciences industry group
26.37
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- AZN
- 26.37
- Q1
- 13.30
- Min
- 0.07
BNTX
Pharmaceuticals, Biotechnology & Life Sciences industry group
--
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- Q1
- 13.30
- Min
- 0.07
- BNTX
- --
P/S Ratio (TTM)
On P/S ratio, both AstraZeneca (AZN) at 4.63 and BioNTech (BNTX) at 8.96 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.
AZN
Pharmaceuticals, Biotechnology & Life Sciences industry group
4.63
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- AZN
- 4.63
- Q1
- 3.01
- Min
- 0.01
BNTX
Pharmaceuticals, Biotechnology & Life Sciences industry group
8.96
- Max
- 58.18
- Q3
- 25.77
- BNTX
- 8.96
- Median
- 7.30
- Q1
- 3.01
- Min
- 0.01
P/B Ratio (MRQ)
BioNTech (BNTX) at 1.09 sits in the lower P/B ratio quartile against book while AstraZeneca (AZN) at 5.59 is valued near its industry’s middle — BNTX is cheaper on assets, though weigh it against ROE and asset quality.
AZN
Pharmaceuticals, Biotechnology & Life Sciences industry group
5.59
- Max
- 13.53
- Q3
- 6.54
- AZN
- 5.59
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
BNTX
Pharmaceuticals, Biotechnology & Life Sciences industry group
1.09
- Max
- 13.53
- Q3
- 6.54
- Median
- 3.25
- Q1
- 1.69
- BNTX
- 1.09
- Min
- -5.59
Valuation Metrics
| Metric | AZN | BNTX |
|---|---|---|
| P/E Ratio (TTM) | 26.37 | -- |
| P/S Ratio (TTM) | 4.63 | 8.96 |
| P/B Ratio (MRQ) | 5.59 | 1.09 |
| Free Cash Flow Yield (TTM) | 1.95% | -7.34% |