ASND vs. SWTX: A Head-to-Head Stock Comparison

Updated on July 7, 2025

Here’s a clear look at ASND and SWTX, comparing key factors like historical performance, profitability, financial strength, growth, dividend, and valuation.

Company Overview

ASND’s market capitalization of 10.52 billion USD is substantially larger than SWTX’s 3.54 billion USD, indicating a significant difference in their market valuations.

SWTX carries a higher beta at 0.70, indicating it’s more sensitive to market moves, while ASND (beta: 0.36) exhibits greater stability.

ASND trades as an American Depositary Receipt (ADR), offering U.S. investors a convenient way to access its foreign-listed shares. In contrast, SWTX is a standard domestic listing.

Symbol	ASND	SWTX
Company Name	Ascendis Pharma A/S	SpringWorks Therapeutics, Inc.
Country	DK	US
Sector	Healthcare	Healthcare
Industry	Biotechnology	Biotechnology
CEO	Jan Moller Mikkelsen	Saqib Islam
Price	174.18 USD	46.99 USD
Market Cap	10.52 billion USD	3.54 billion USD
Beta	0.36	0.70
Exchange	NASDAQ	NASDAQ
IPO Date	January 28, 2015	September 13, 2019
ADR	Yes	No

Historical Performance

This chart compares the performance of ASND and SWTX by tracking the growth of an initial $10,000 investment in each. Use the tabs to select the desired time period.

Data is adjusted for dividends and splits.

ASND vs. SWTX: Growth of a $10,000 investment over the past one year.

Profitability

Return on Equity

ASND

191.42%

Biotechnology Industry

Max: 72.39%
Q3: -6.30%
Median: -32.82%
Q1: -68.26%
Min: -147.61%

ASND’s Return on Equity of 191.42% is exceptionally high, placing it well beyond the typical range for the Biotechnology industry. This demonstrates a superior ability to generate profit from shareholder investments, though it could also be inflated by high financial leverage.

SWTX

-51.10%

Biotechnology Industry

Max: 72.39%
Q3: -6.30%
Median: -32.82%
Q1: -68.26%
Min: -147.61%

SWTX has a negative Return on Equity of -51.10%. This indicates the company is generating a loss for its shareholders, which can be a result of unprofitability or negative shareholder equity and is often a sign of financial distress.

ASND vs. SWTX: A comparison of their ROE against the Biotechnology industry benchmark.

Return on Invested Capital

ASND

-50.64%

Biotechnology Industry

Max: 48.74%
Q3: -10.68%
Median: -31.65%
Q1: -52.92%
Min: -113.69%

ASND has a negative Return on Invested Capital of -50.64%. This indicates that its operations are failing to generate a profit on the total capital invested, signaling significant inefficiency or value destruction.

SWTX

-62.32%

Biotechnology Industry

Max: 48.74%
Q3: -10.68%
Median: -31.65%
Q1: -52.92%
Min: -113.69%

SWTX has a negative Return on Invested Capital of -62.32%. This indicates that its operations are failing to generate a profit on the total capital invested, signaling significant inefficiency or value destruction.

ASND vs. SWTX: A comparison of their ROIC against the Biotechnology industry benchmark.

Net Profit Margin

ASND

-92.67%

Biotechnology Industry

Max: 87.75%
Q3: -5.05%
Median: -103.44%
Q1: -1,032.77%
Min: -2,366.07%

ASND has a negative Net Profit Margin of -92.67%, indicating the company is operating at a net loss as its expenses exceeded its revenues.

SWTX

-115.60%

Biotechnology Industry

Max: 87.75%
Q3: -5.05%
Median: -103.44%
Q1: -1,032.77%
Min: -2,366.07%

SWTX has a negative Net Profit Margin of -115.60%, indicating the company is operating at a net loss as its expenses exceeded its revenues.

ASND vs. SWTX: A comparison of their Net Profit Margin against the Biotechnology industry benchmark.

Operating Profit Margin

ASND

-90.54%

Biotechnology Industry

Max: 87.75%
Q3: -3.28%
Median: -115.26%
Q1: -1,188.86%
Min: -2,943.30%

ASND has a negative Operating Profit Margin of -90.54%. This signifies the company is unprofitable at the operational level, as its core business expenses exceed its revenue.

SWTX

-120.52%

Biotechnology Industry

Max: 87.75%
Q3: -3.28%
Median: -115.26%
Q1: -1,188.86%
Min: -2,943.30%

SWTX has a negative Operating Profit Margin of -120.52%. This signifies the company is unprofitable at the operational level, as its core business expenses exceed its revenue.

ASND vs. SWTX: A comparison of their Operating Margin against the Biotechnology industry benchmark.

Profitability at a Glance

Symbol	ASND	SWTX
Return on Equity (TTM)	191.42%	-51.10%
Return on Assets (TTM)	-32.19%	-50.25%
Return on Invested Capital (TTM)	-50.64%	-62.32%
Net Profit Margin (TTM)	-92.67%	-115.60%
Operating Profit Margin (TTM)	-90.54%	-120.52%
Gross Profit Margin (TTM)	85.30%	93.23%

Financial Strength

Current Ratio

ASND

1.04

Biotechnology Industry

Max: 28.73
Q3: 13.97
Median: 6.31
Q1: 3.60
Min: 0.02

ASND’s Current Ratio of 1.04 falls into the lower quartile for the Biotechnology industry. This indicates a tighter liquidity situation and a more constrained capacity to handle short-term debt than many of its competitors.

SWTX

4.33

Biotechnology Industry

Max: 28.73
Q3: 13.97
Median: 6.31
Q1: 3.60
Min: 0.02

SWTX’s Current Ratio of 4.33 aligns with the median group of the Biotechnology industry, indicating that its short-term liquidity is in line with its sector peers.

ASND vs. SWTX: A comparison of their Current Ratio against the Biotechnology industry benchmark.

Debt-to-Equity Ratio

ASND

-4.46

Biotechnology Industry

Max: 0.46
Q3: 0.22
Median: 0.06
Q1: 0.02
Min: 0.00

ASND has a Debt-to-Equity Ratio of -4.46, which indicates negative shareholder equity where liabilities exceed assets. This is a critical sign of financial distress.

SWTX

0.02

Biotechnology Industry

Max: 0.46
Q3: 0.22
Median: 0.06
Q1: 0.02
Min: 0.00

SWTX’s Debt-to-Equity Ratio of 0.02 is typical for the Biotechnology industry, indicating its use of leverage is in line with the sector norm. This suggests a balanced approach to its capital structure.

ASND vs. SWTX: A comparison of their D/E Ratio against the Biotechnology industry benchmark.

Interest Coverage Ratio

ASND

-3.72

Biotechnology Industry

Max: 108.32
Q3: -0.55
Median: -8.49
Q1: -74.83
Min: -168.36

ASND has a negative Interest Coverage Ratio of -3.72. This indicates that its earnings were insufficient to cover even its operational costs, let alone its interest payments, signaling significant financial distress.

SWTX

265.27

Biotechnology Industry

Max: 108.32
Q3: -0.55
Median: -8.49
Q1: -74.83
Min: -168.36

With an Interest Coverage Ratio of 265.27, SWTX demonstrates a superior capacity to service its debt, placing it well above the typical range for the Biotechnology industry. This stems from either robust earnings or a conservative debt load.

ASND vs. SWTX: A comparison of their Interest Coverage against the Biotechnology industry benchmark.

Financial Strength at a Glance

Symbol	ASND	SWTX
Current Ratio (TTM)	1.04	4.33
Quick Ratio (TTM)	0.71	4.18
Debt-to-Equity Ratio (TTM)	-4.46	0.02
Debt-to-Asset Ratio (TTM)	0.80	0.01
Net Debt-to-EBITDA Ratio (TTM)	-1.34	0.22
Interest Coverage Ratio (TTM)	-3.72	265.27

Growth

The following charts compare key year-over-year (YoY) growth metrics for ASND and SWTX. These metrics are based on the companies’ annual financial reports.

Revenue Growth

ASND vs. SWTX: A comparison of their annual year-over-year Revenue Growth.

Earnings Per Share (EPS) Growth

ASND vs. SWTX: A comparison of their annual year-over-year Earnings Per Share (EPS) Growth.

Free Cash Flow Growth

ASND vs. SWTX: A comparison of their annual year-over-year Free Cash Flow Growth.

Dividend

Dividend Yield

ASND

0.00%

Biotechnology Industry

Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

ASND currently does not pay a dividend, resulting in a yield of 0%. This is a common strategy for growth-focused companies that prioritize reinvesting earnings, though it may be less typical in mature, income-oriented sectors.

SWTX

0.00%

Biotechnology Industry

Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

SWTX currently does not pay a dividend, resulting in a yield of 0%. This is a common strategy for growth-focused companies that prioritize reinvesting earnings, though it may be less typical in mature, income-oriented sectors.

ASND vs. SWTX: A comparison of their Dividend Yield against the Biotechnology industry benchmark.

Dividend Payout Ratio

ASND

0.00%

Biotechnology Industry

Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

ASND has a Dividend Payout Ratio of 0%, indicating it does not currently pay a dividend. This is a common strategy for growth-oriented companies that reinvest all profits back into the business.

SWTX

0.00%

Biotechnology Industry

Max: 0.00%
Q3: 0.00%
Median: 0.00%
Q1: 0.00%
Min: 0.00%

SWTX has a Dividend Payout Ratio of 0%, indicating it does not currently pay a dividend. This is a common strategy for growth-oriented companies that reinvest all profits back into the business.

ASND vs. SWTX: A comparison of their Payout Ratio against the Biotechnology industry benchmark.

Dividend at a Glance

Symbol	ASND	SWTX
Dividend Yield (TTM)	0.00%	0.00%
Dividend Payout Ratio (TTM)	0.00%	0.00%

Valuation

Price-to-Earnings Ratio

ASND

-25.98

Biotechnology Industry

Max: 78.44
Q3: 48.98
Median: 20.50
Q1: 12.64
Min: 2.14

ASND has a negative P/E Ratio of -25.98. This occurs when a company has negative earnings (a net loss), making the ratio unsuitable for valuation analysis.

SWTX

-13.86

Biotechnology Industry

Max: 78.44
Q3: 48.98
Median: 20.50
Q1: 12.64
Min: 2.14

SWTX has a negative P/E Ratio of -13.86. This occurs when a company has negative earnings (a net loss), making the ratio unsuitable for valuation analysis.

ASND vs. SWTX: A comparison of their P/E Ratio against the Biotechnology industry benchmark.

Forward P/E to Growth Ratio

ASND

-2.36

Biotechnology Industry

Max: 2.29
Q3: 1.10
Median: 0.49
Q1: 0.16
Min: 0.02

ASND has a negative Forward PEG Ratio of -2.36. This typically results from negative earnings or forecasts of declining future earnings, making the ratio not meaningful for valuation.

SWTX

-6.89

Biotechnology Industry

Max: 2.29
Q3: 1.10
Median: 0.49
Q1: 0.16
Min: 0.02

SWTX has a negative Forward PEG Ratio of -6.89. This typically results from negative earnings or forecasts of declining future earnings, making the ratio not meaningful for valuation.

ASND vs. SWTX: A comparison of their Forward PEG Ratio against the Biotechnology industry benchmark.

Price-to-Sales Ratio

ASND

24.22

Biotechnology Industry

Max: 110.90
Q3: 59.76
Median: 11.33
Q1: 4.45
Min: 0.17

ASND’s P/S Ratio of 24.22 aligns with the market consensus for the Biotechnology industry. This suggests its valuation, based on sales, is seen as standard and is on par with its competitors.

SWTX

16.12

Biotechnology Industry

Max: 110.90
Q3: 59.76
Median: 11.33
Q1: 4.45
Min: 0.17

SWTX’s P/S Ratio of 16.12 aligns with the market consensus for the Biotechnology industry. This suggests its valuation, based on sales, is seen as standard and is on par with its competitors.

ASND vs. SWTX: A comparison of their P/S Ratio against the Biotechnology industry benchmark.

Price-to-Book Ratio

ASND

-46.77

Biotechnology Industry

Max: 15.78
Q3: 7.44
Median: 3.31
Q1: 1.58
Min: 0.31

The P/B Ratio is often not a primary valuation metric for the Biotechnology industry.

SWTX

8.43

Biotechnology Industry

Max: 15.78
Q3: 7.44
Median: 3.31
Q1: 1.58
Min: 0.31

The P/B Ratio is often not a primary valuation metric for the Biotechnology industry.

ASND vs. SWTX: A comparison of their P/B Ratio against the Biotechnology industry benchmark.

Valuation at a Glance

Symbol	ASND	SWTX
Price-to-Earnings Ratio (P/E, TTM)	-25.98	-13.86
Forward PEG Ratio (TTM)	-2.36	-6.89
Price-to-Sales Ratio (P/S, TTM)	24.22	16.12
Price-to-Book Ratio (P/B, TTM)	-46.77	8.43
Price-to-Free Cash Flow Ratio (P/FCF, TTM)	-29.03	-20.31
EV-to-EBITDA (TTM)	-37.74	-13.30
EV-to-Sales (TTM)	25.11	15.86