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ASND vs. NVO: Ascendis Pharma vs. Novo Nordisk Stock Comparison

How do Ascendis Pharma (ASND) and Novo Nordisk (NVO) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Ascendis Pharma (ASND) and Novo Nordisk (NVO) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but ASND is classified in Biotechnology while NVO is classified in Pharmaceuticals.

Ascendis Pharma (ASND) trades as ordinary local shares, while Novo Nordisk (NVO) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.

Company profile comparison for Ascendis Pharma (ASND) and Novo Nordisk (NVO)
Profile ItemASNDNVO
NameAscendis Pharma A/SNovo Nordisk A/S Sponsored ADR
Country/RegionDenmarkDenmark
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnologyPharmaceuticals
GICS Sub-IndustryBiotechnologyPharmaceuticals
Market Capitalization16.90 billion USD177.74 billion USD
CurrencyUSDUSD
ExchangeNasdaqNYSE
Listing DateJanuary 28, 2015April 30, 1981
Security TypeCommon StockADR

Price Performance

Cumulative Growth

ASND
NVO
GSPC
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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Ascendis Pharma (ASND) and Novo Nordisk (NVO). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Ascendis Pharma (ASND) and Novo Nordisk (NVO). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Ascendis Pharma (ASND) and Novo Nordisk (NVO)
MetricASNDNVO
Total Return (1Y)29.46%-5.29%
Total Return (3Y, Annualized)40.62%-23.41%
Total Return (5Y, Annualized)10.03%-4.13%

Risk Profile

Drawdown History

ASND
NVO
GSPC
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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Ascendis Pharma (ASND) and Novo Nordisk (NVO). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Novo Nordisk (NVO) is heavily traded at around 12.11M shares per day, whereas Ascendis Pharma (ASND) sees a more moderate 698.39K — larger orders in the latter may require more patience and tighter control over order sizing.

Risk profile metrics for Ascendis Pharma (ASND) and Novo Nordisk (NVO)
MetricASNDNVO
Volatility (1Y, Annualized)38.62%45.98%
Beta (5Y)0.380.67
Max Drawdown (5Y)-55.93%-74.70%
Avg. Volume (3M)698.39K12.11M

Risk-Adjusted Performance

Risk-Return Positioning

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ASND and NVO are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Ascendis Pharma (ASND) and Novo Nordisk (NVO)
MetricASNDNVO
Sharpe Ratio (1Y)0.65-0.21
Sortino Ratio (1Y)0.99-0.28

Profitability

ROE (TTM)

Both companies show strong equity returns, but Ascendis Pharma (ASND) at 118.78% is the standout with ROE above its industry range; Novo Nordisk (NVO) at 58.38% also sits in the top quartile.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

118.78%

ASND
118.78%
Max
109.18%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

58.38%

Max
109.18%
NVO
58.38%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Both Ascendis Pharma (ASND) at 70.85% and Novo Nordisk (NVO) at 33.92% keep an unusually large share of revenue as bottom-line profit — each net margin clears its industry’s benchmark range.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

70.85%

ASND
70.85%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

33.92%

NVO
33.92%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Ascendis Pharma (ASND) at 64.98% and Novo Nordisk (NVO) at 40.05% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

64.98%

Max
83.12%
ASND
64.98%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

40.05%

Max
83.12%
NVO
40.05%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Ascendis Pharma (ASND) and Novo Nordisk (NVO)
MetricASNDNVO
ROE (TTM)118.78%58.38%
ROA (TTM)9.58%19.05%
Net Margin (TTM)70.85%33.92%
Operating Margin (TTM)64.98%40.05%
Gross Margin (TTM)91.30%83.33%

Growth

Revenue Growth

Ascendis Pharma (ASND) at 98.03% sits in the top revenue growth quartile, while Novo Nordisk (NVO) at 6.43% is closer to the peer norm — faster top-line expansion for ASND.

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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their Revenue Growth across different time periods.

EPS Growth

Only one side can be read here: Novo Nordisk (NVO) reports EPS growth of 1.77%, ranked against its industry; Ascendis Pharma (ASND) has no EPS growth figure this period.

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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Ascendis Pharma (ASND) and Novo Nordisk (NVO)
MetricASNDNVO
Revenue Growth (YoY)98.03%6.43%
Revenue Growth (3Y CAGR)141.43%20.43%
EPS Growth (YoY)--1.77%
EPS Growth (3Y CAGR)--23.52%

Financial Strength

Current Ratio (MRQ)

Ascendis Pharma (ASND) at 2.99 keeps current ratio within its industry’s typical mid-range, while Novo Nordisk (NVO) at 0.85 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for NVO.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.99

Max
25.13
Q3
12.13
Median
5.52
ASND
2.99
Q1
2.47
Min
0.10

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.85

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
NVO
0.85
Min
0.10
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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Both Ascendis Pharma (ASND) at 0.31 and Novo Nordisk (NVO) at 0.62 fund their balance sheets with roughly industry-typical debt-to-equity mixes.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.31

Max
1.42
Q3
0.65
ASND
0.31
Median
0.15
Q1
0.02
Min
0.00

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.62

Max
1.42
Q3
0.65
NVO
0.62
Median
0.15
Q1
0.02
Min
0.00
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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Ascendis Pharma (ASND) and Novo Nordisk (NVO)
MetricASNDNVO
Current Ratio (MRQ)2.990.85
Debt / Equity (MRQ)0.310.62
Net Debt / EBITDA-1.370.49

Dividends

Dividend Yield (TTM)

Ascendis Pharma (ASND) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Novo Nordisk (NVO) reports a yield of 29.03%, ranking against industry peers normally.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ASND
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

29.03%

NVO
29.03%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Ascendis Pharma (ASND) pays no dividend (payout 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Novo Nordisk (NVO) reports a payout of 45.36%, ranking against industry peers normally.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ASND
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

45.36%

NVO
45.36%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Ascendis Pharma (ASND) and Novo Nordisk (NVO)
MetricASNDNVO
Dividend Yield (TTM)0.00%29.03%
Dividend Payout Ratio (TTM)0.00%45.36%

Valuation

P/E Ratio (TTM)

Novo Nordisk (NVO) at 10.18 sits in the cheaper P/E ratio quartile, while Ascendis Pharma (ASND) at 19.68 is closer to its industry’s usual earnings multiple — a discount for NVO, though growth and earnings durability still matter.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

19.68

Max
85.34
Q3
43.46
Median
26.69
ASND
19.68
Q1
13.30
Min
0.07

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

10.18

Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
NVO
10.18
Min
0.07
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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

Novo Nordisk (NVO) at 0.53 sits in the cheaper P/S ratio quartile while Ascendis Pharma (ASND) at 16.14 prices around its industry’s middle — NVO costs less per dollar of sales, though read it alongside growth and margins.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

16.14

Max
58.18
Q3
25.77
ASND
16.14
Median
7.30
Q1
3.01
Min
0.01

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.53

Max
58.18
Q3
25.77
Median
7.30
Q1
3.01
NVO
0.53
Min
0.01
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Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Novo Nordisk (NVO) at 5.43 is valued about in line with its industry on P/B ratio, while Ascendis Pharma (ASND) at 10.45 carries an above-peer premium to book — ASND is pricier on assets.

ASND

Pharmaceuticals, Biotechnology & Life Sciences industry group

10.45

Max
13.53
ASND
10.45
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.43

Max
13.53
Q3
6.54
NVO
5.43
Median
3.25
Q1
1.69
Min
-5.59
Loading chart…
Ascendis Pharma (ASND) vs. Novo Nordisk (NVO): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Ascendis Pharma (ASND) and Novo Nordisk (NVO)
MetricASNDNVO
P/E Ratio (TTM)19.6810.18
P/S Ratio (TTM)16.140.53
P/B Ratio (MRQ)10.455.43
Free Cash Flow Yield (TTM)0.08%18.43%