ASND vs. NVO: Ascendis Pharma vs. Novo Nordisk Stock Comparison
How do Ascendis Pharma (ASND) and Novo Nordisk (NVO) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.
Company Profile
Ascendis Pharma (ASND) and Novo Nordisk (NVO) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but ASND is classified in Biotechnology while NVO is classified in Pharmaceuticals.
Ascendis Pharma (ASND) trades as ordinary local shares, while Novo Nordisk (NVO) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.
| Profile Item | ASND | NVO |
|---|---|---|
| Name | Ascendis Pharma A/S | Novo Nordisk A/S Sponsored ADR |
| Country/Region | Denmark | Denmark |
| GICS Sector | Health Care | Health Care |
| GICS Industry Group | Pharmaceuticals, Biotechnology & Life Sciences | Pharmaceuticals, Biotechnology & Life Sciences |
| GICS Industry | Biotechnology | Pharmaceuticals |
| GICS Sub-Industry | Biotechnology | Pharmaceuticals |
| Market Capitalization | 16.90 billion USD | 177.74 billion USD |
| Currency | USD | USD |
| Exchange | Nasdaq | NYSE |
| Listing Date | January 28, 2015 | April 30, 1981 |
| Security Type | Common Stock | ADR |
Price Performance
Cumulative Growth
Trailing Returns
Calendar-Year Returns
Performance Metrics
| Metric | ASND | NVO |
|---|---|---|
| Total Return (1Y) | 29.46% | -5.29% |
| Total Return (3Y, Annualized) | 40.62% | -23.41% |
| Total Return (5Y, Annualized) | 10.03% | -4.13% |
Risk Profile
Drawdown History
Return Distribution
Risk Metrics
Novo Nordisk (NVO) is heavily traded at around 12.11M shares per day, whereas Ascendis Pharma (ASND) sees a more moderate 698.39K — larger orders in the latter may require more patience and tighter control over order sizing.
| Metric | ASND | NVO |
|---|---|---|
| Volatility (1Y, Annualized) | 38.62% | 45.98% |
| Beta (5Y) | 0.38 | 0.67 |
| Max Drawdown (5Y) | -55.93% | -74.70% |
| Avg. Volume (3M) | 698.39K | 12.11M |
Risk-Adjusted Performance
Risk-Return Positioning
Risk-Adjusted Metrics
| Metric | ASND | NVO |
|---|---|---|
| Sharpe Ratio (1Y) | 0.65 | -0.21 |
| Sortino Ratio (1Y) | 0.99 | -0.28 |
Profitability
ROE (TTM)
Both companies show strong equity returns, but Ascendis Pharma (ASND) at 118.78% is the standout with ROE above its industry range; Novo Nordisk (NVO) at 58.38% also sits in the top quartile.
ASND
Pharmaceuticals, Biotechnology & Life Sciences industry group
118.78%
- ASND
- 118.78%
- Max
- 109.18%
- Q3
- 6.23%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
58.38%
- Max
- 109.18%
- NVO
- 58.38%
- Q3
- 6.23%
- Median
- -26.66%
- Q1
- -64.05%
- Min
- -167.77%
Net Margin (TTM)
Both Ascendis Pharma (ASND) at 70.85% and Novo Nordisk (NVO) at 33.92% keep an unusually large share of revenue as bottom-line profit — each net margin clears its industry’s benchmark range.
ASND
Pharmaceuticals, Biotechnology & Life Sciences industry group
70.85%
- ASND
- 70.85%
- Max
- 18.05%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
33.92%
- NVO
- 33.92%
- Max
- 18.05%
- Q3
- 4.78%
- Median
- 0.00%
- Q1
- -4.14%
- Min
- -17.05%
Operating Margin (TTM)
Both Ascendis Pharma (ASND) at 64.98% and Novo Nordisk (NVO) at 40.05% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.
ASND
Pharmaceuticals, Biotechnology & Life Sciences industry group
64.98%
- Max
- 83.12%
- ASND
- 64.98%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
40.05%
- Max
- 83.12%
- NVO
- 40.05%
- Q3
- 14.77%
- Median
- 0.00%
- Q1
- -78.82%
- Min
- -207.40%
Profitability Metrics
| Metric | ASND | NVO |
|---|---|---|
| ROE (TTM) | 118.78% | 58.38% |
| ROA (TTM) | 9.58% | 19.05% |
| Net Margin (TTM) | 70.85% | 33.92% |
| Operating Margin (TTM) | 64.98% | 40.05% |
| Gross Margin (TTM) | 91.30% | 83.33% |
Growth
Revenue Growth
Ascendis Pharma (ASND) at 98.03% sits in the top revenue growth quartile, while Novo Nordisk (NVO) at 6.43% is closer to the peer norm — faster top-line expansion for ASND.
EPS Growth
Only one side can be read here: Novo Nordisk (NVO) reports EPS growth of 1.77%, ranked against its industry; Ascendis Pharma (ASND) has no EPS growth figure this period.
Growth Metrics
| Metric | ASND | NVO |
|---|---|---|
| Revenue Growth (YoY) | 98.03% | 6.43% |
| Revenue Growth (3Y CAGR) | 141.43% | 20.43% |
| EPS Growth (YoY) | -- | 1.77% |
| EPS Growth (3Y CAGR) | -- | 23.52% |
Financial Strength
Current Ratio (MRQ)
Ascendis Pharma (ASND) at 2.99 keeps current ratio within its industry’s typical mid-range, while Novo Nordisk (NVO) at 0.85 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for NVO.
ASND
Pharmaceuticals, Biotechnology & Life Sciences industry group
2.99
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- ASND
- 2.99
- Q1
- 2.47
- Min
- 0.10
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.85
- Max
- 25.13
- Q3
- 12.13
- Median
- 5.52
- Q1
- 2.47
- NVO
- 0.85
- Min
- 0.10
Debt / Equity (MRQ)
Both Ascendis Pharma (ASND) at 0.31 and Novo Nordisk (NVO) at 0.62 fund their balance sheets with roughly industry-typical debt-to-equity mixes.
ASND
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.31
- Max
- 1.42
- Q3
- 0.65
- ASND
- 0.31
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.62
- Max
- 1.42
- Q3
- 0.65
- NVO
- 0.62
- Median
- 0.15
- Q1
- 0.02
- Min
- 0.00
Financial Strength Metrics
| Metric | ASND | NVO |
|---|---|---|
| Current Ratio (MRQ) | 2.99 | 0.85 |
| Debt / Equity (MRQ) | 0.31 | 0.62 |
| Net Debt / EBITDA | -1.37 | 0.49 |
Dividends
Dividend Yield (TTM)
Ascendis Pharma (ASND) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Novo Nordisk (NVO) reports a yield of 29.03%, ranking against industry peers normally.
ASND
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- ASND
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
29.03%
- NVO
- 29.03%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Payout Ratio (TTM)
Ascendis Pharma (ASND) pays no dividend (payout 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Novo Nordisk (NVO) reports a payout of 45.36%, ranking against industry peers normally.
ASND
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.00%
- ASND
- 0.00%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
45.36%
- NVO
- 45.36%
- Max
- 0.00%
- Q3
- 0.00%
- Median
- 0.00%
- Q1
- 0.00%
- Min
- 0.00%
Dividend Metrics
| Metric | ASND | NVO |
|---|---|---|
| Dividend Yield (TTM) | 0.00% | 29.03% |
| Dividend Payout Ratio (TTM) | 0.00% | 45.36% |
Valuation
P/E Ratio (TTM)
Novo Nordisk (NVO) at 10.18 sits in the cheaper P/E ratio quartile, while Ascendis Pharma (ASND) at 19.68 is closer to its industry’s usual earnings multiple — a discount for NVO, though growth and earnings durability still matter.
ASND
Pharmaceuticals, Biotechnology & Life Sciences industry group
19.68
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- ASND
- 19.68
- Q1
- 13.30
- Min
- 0.07
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
10.18
- Max
- 85.34
- Q3
- 43.46
- Median
- 26.69
- Q1
- 13.30
- NVO
- 10.18
- Min
- 0.07
P/S Ratio (TTM)
Novo Nordisk (NVO) at 0.53 sits in the cheaper P/S ratio quartile while Ascendis Pharma (ASND) at 16.14 prices around its industry’s middle — NVO costs less per dollar of sales, though read it alongside growth and margins.
ASND
Pharmaceuticals, Biotechnology & Life Sciences industry group
16.14
- Max
- 58.18
- Q3
- 25.77
- ASND
- 16.14
- Median
- 7.30
- Q1
- 3.01
- Min
- 0.01
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
0.53
- Max
- 58.18
- Q3
- 25.77
- Median
- 7.30
- Q1
- 3.01
- NVO
- 0.53
- Min
- 0.01
P/B Ratio (MRQ)
Novo Nordisk (NVO) at 5.43 is valued about in line with its industry on P/B ratio, while Ascendis Pharma (ASND) at 10.45 carries an above-peer premium to book — ASND is pricier on assets.
ASND
Pharmaceuticals, Biotechnology & Life Sciences industry group
10.45
- Max
- 13.53
- ASND
- 10.45
- Q3
- 6.54
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
NVO
Pharmaceuticals, Biotechnology & Life Sciences industry group
5.43
- Max
- 13.53
- Q3
- 6.54
- NVO
- 5.43
- Median
- 3.25
- Q1
- 1.69
- Min
- -5.59
Valuation Metrics
| Metric | ASND | NVO |
|---|---|---|
| P/E Ratio (TTM) | 19.68 | 10.18 |
| P/S Ratio (TTM) | 16.14 | 0.53 |
| P/B Ratio (MRQ) | 10.45 | 5.43 |
| Free Cash Flow Yield (TTM) | 0.08% | 18.43% |