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ALNY vs. NVS: Alnylam Pharmaceuticals vs. Novartis Stock Comparison

How do Alnylam Pharmaceuticals (ALNY) and Novartis (NVS) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Alnylam Pharmaceuticals (ALNY) and Novartis (NVS) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but ALNY is classified in Biotechnology while NVS is classified in Pharmaceuticals.

Alnylam Pharmaceuticals (ALNY) trades as ordinary local shares, while Novartis (NVS) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.

Company profile comparison for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS)
Profile ItemALNYNVS
NameAlnylam Pharmaceuticals, Inc.Novartis AG Sponsored ADR
Country/RegionUnited StatesSwitzerland
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnologyPharmaceuticals
GICS Sub-IndustryBiotechnologyPharmaceuticals
Market Capitalization20.89 billion USD307.00 billion USD
CurrencyUSDUSD
ExchangeNasdaqNYSE
Listing DateJune 1, 2004November 7, 1996
Security TypeCommon StockADR

Price Performance

Cumulative Growth

ALNY
NVS
GSPC
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS)
MetricALNYNVS
Total Return (1Y)-64.57%32.98%
Total Return (3Y, Annualized)-1.58%24.72%
Total Return (5Y, Annualized)-3.13%18.80%

Risk Profile

Drawdown History

ALNY
NVS
GSPC
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS)
MetricALNYNVS
Volatility (1Y, Annualized)54.08%27.12%
Beta (5Y)0.450.41
Max Drawdown (5Y)-68.25%-20.42%
Avg. Volume (3M)1.90M2.07M

Risk-Adjusted Performance

Risk-Return Positioning

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ALNY and NVS are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS)
MetricALNYNVS
Sharpe Ratio (1Y)-1.271.06
Sortino Ratio (1Y)-1.451.46

Profitability

ROE (TTM)

Both companies show strong equity returns, but Alnylam Pharmaceuticals (ALNY) at 138.07% is the standout with ROE above its industry range; Novartis (NVS) at 24.33% also sits in the top quartile.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

138.07%

ALNY
138.07%
Max
109.18%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

NVS

Pharmaceuticals, Biotechnology & Life Sciences industry group

24.33%

Max
109.18%
NVS
24.33%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Alnylam Pharmaceuticals (ALNY) at 52.85% keeps the most of each sales dollar — above its industry’s net margin range — and Novartis (NVS) at 17.49% also retains a top-quartile share.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

52.85%

ALNY
52.85%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%

NVS

Pharmaceuticals, Biotechnology & Life Sciences industry group

17.49%

Max
18.05%
NVS
17.49%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Alnylam Pharmaceuticals (ALNY) at 23.72% and Novartis (NVS) at 34.27% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

23.72%

Max
83.12%
ALNY
23.72%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

NVS

Pharmaceuticals, Biotechnology & Life Sciences industry group

34.27%

Max
83.12%
NVS
34.27%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS)
MetricALNYNVS
ROE (TTM)138.07%24.33%
ROA (TTM)9.51%10.86%
Net Margin (TTM)52.85%17.49%
Operating Margin (TTM)23.72%34.27%
Gross Margin (TTM)77.28%75.21%

Growth

Revenue Growth

Alnylam Pharmaceuticals (ALNY) at 65.19% sits in the top revenue growth quartile, while Novartis (NVS) at 9.57% is closer to the peer norm — faster top-line expansion for ALNY.

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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their Revenue Growth across different time periods.

EPS Growth

Only one side can be read here: Novartis (NVS) reports EPS growth of 21.81%, ranked against its industry; Alnylam Pharmaceuticals (ALNY) has no EPS growth figure this period.

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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS)
MetricALNYNVS
Revenue Growth (YoY)65.19%9.57%
Revenue Growth (3Y CAGR)52.98%9.25%
EPS Growth (YoY)--21.81%
EPS Growth (3Y CAGR)--31.14%

Financial Strength

Current Ratio (MRQ)

Alnylam Pharmaceuticals (ALNY) at 2.48 keeps current ratio within its industry’s typical mid-range, while Novartis (NVS) at 0.88 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for NVS.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.48

Max
25.13
Q3
12.13
Median
5.52
ALNY
2.48
Q1
2.47
Min
0.10

NVS

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.88

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
NVS
0.88
Min
0.10
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Both Alnylam Pharmaceuticals (ALNY) at 0.83 and Novartis (NVS) at 1.29 lean more heavily on debt funding than most peers, landing in the higher-leverage quartile of their industries.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.83

Max
1.42
ALNY
0.83
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00

NVS

Pharmaceuticals, Biotechnology & Life Sciences industry group

1.29

Max
1.42
NVS
1.29
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS)
MetricALNYNVS
Current Ratio (MRQ)2.480.88
Debt / Equity (MRQ)0.831.29
Net Debt / EBITDA-0.571.64

Dividends

Dividend Yield (TTM)

Alnylam Pharmaceuticals (ALNY) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Novartis (NVS) reports a yield of 2.88%, ranking against industry peers normally.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ALNY
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

NVS

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.88%

NVS
2.88%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Alnylam Pharmaceuticals (ALNY) pays no dividend (payout 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Novartis (NVS) reports a payout of 90.46%, ranking against industry peers normally.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ALNY
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

NVS

Pharmaceuticals, Biotechnology & Life Sciences industry group

90.46%

NVS
90.46%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS)
MetricALNYNVS
Dividend Yield (TTM)0.00%2.88%
Dividend Payout Ratio (TTM)0.00%90.46%

Valuation

P/E Ratio (TTM)

Alnylam Pharmaceuticals (ALNY) at 7.88 sits in the cheaper P/E ratio quartile, while Novartis (NVS) at 31.02 is closer to its industry’s usual earnings multiple — a discount for ALNY, though growth and earnings durability still matter.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.88

Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
ALNY
7.88
Min
0.07

NVS

Pharmaceuticals, Biotechnology & Life Sciences industry group

31.02

Max
85.34
Q3
43.46
NVS
31.02
Median
26.69
Q1
13.30
Min
0.07
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

On P/S ratio, both Alnylam Pharmaceuticals (ALNY) at 4.17 and Novartis (NVS) at 5.35 are priced roughly in line with their industries — neither looks cheap nor rich on a sales basis.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.17

Max
58.18
Q3
25.77
Median
7.30
ALNY
4.17
Q1
3.01
Min
0.01

NVS

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.35

Max
58.18
Q3
25.77
Median
7.30
NVS
5.35
Q1
3.01
Min
0.01
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

Alnylam Pharmaceuticals (ALNY) at 5.79 is valued about in line with its industry on P/B ratio, while Novartis (NVS) at 8.25 carries an above-peer premium to book — NVS is pricier on assets.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.79

Max
13.53
Q3
6.54
ALNY
5.79
Median
3.25
Q1
1.69
Min
-5.59

NVS

Pharmaceuticals, Biotechnology & Life Sciences industry group

8.25

Max
13.53
NVS
8.25
Q3
6.54
Median
3.25
Q1
1.69
Min
-5.59
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Alnylam Pharmaceuticals (ALNY) vs. Novartis (NVS): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Alnylam Pharmaceuticals (ALNY) and Novartis (NVS)
MetricALNYNVS
P/E Ratio (TTM)7.8831.02
P/S Ratio (TTM)4.175.35
P/B Ratio (MRQ)5.798.25
Free Cash Flow Yield (TTM)1.57%3.67%