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ALNY vs. NVO: Alnylam Pharmaceuticals vs. Novo Nordisk Stock Comparison

How do Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO) stack up? This page sets them side by side across company profile, performance and risk, profitability, growth, financial strength, dividends, and valuation, with selected fundamentals also measured against each stock's industry-group peers.

Company Profile

Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO) both fall under the Pharmaceuticals, Biotechnology & Life Sciences industry group, but ALNY is classified in Biotechnology while NVO is classified in Pharmaceuticals.

Alnylam Pharmaceuticals (ALNY) trades as ordinary local shares, while Novo Nordisk (NVO) trades as an ADR — compare with FX exposure, depositary-program fees, and dividend-withholding-tax differences in mind.

Company profile comparison for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO)
Profile ItemALNYNVO
NameAlnylam Pharmaceuticals, Inc.Novo Nordisk A/S Sponsored ADR
Country/RegionUnited StatesDenmark
GICS SectorHealth CareHealth Care
GICS Industry GroupPharmaceuticals, Biotechnology & Life SciencesPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnologyPharmaceuticals
GICS Sub-IndustryBiotechnologyPharmaceuticals
Market Capitalization20.89 billion USD177.74 billion USD
CurrencyUSDUSD
ExchangeNasdaqNYSE
Listing DateJune 1, 2004April 30, 1981
Security TypeCommon StockADR

Price Performance

Cumulative Growth

ALNY
NVO
GSPC
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO), with S&P 500 (GSPC) for reference: Growth of a $10,000 investment over the past five years. Adjusted for dividends and splits.

Trailing Returns

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Trailing total returns for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO). Returns over one year are annualized.

Calendar-Year Returns

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Calendar-year total returns for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO). Each bar is that year's total return, measured year-end to year-end.

Performance Metrics

Price performance metrics for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO)
MetricALNYNVO
Total Return (1Y)-64.57%-5.29%
Total Return (3Y, Annualized)-1.58%-23.41%
Total Return (5Y, Annualized)-3.13%-4.13%

Risk Profile

Drawdown History

ALNY
NVO
GSPC
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO), with S&P 500 (GSPC) for reference: Drawdown from the running peak over the past five years. Each line shows the decline from its prior peak; 0% marks a new high.

Return Distribution

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Distribution of monthly total returns for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO). Each bar is the share of months whose return fell in that 5% bucket.

Risk Metrics

Risk profile metrics for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO)
MetricALNYNVO
Volatility (1Y, Annualized)54.08%45.98%
Beta (5Y)0.450.67
Max Drawdown (5Y)-68.25%-74.70%
Avg. Volume (3M)1.90M12.11M

Risk-Adjusted Performance

Risk-Return Positioning

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ALNY and NVO are plotted by 1-year volatility (risk) and 1-year return. The dashed Capital Allocation Line runs from the risk-free rate through the shared industry median.

Risk-Adjusted Metrics

Risk-adjusted metrics for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO)
MetricALNYNVO
Sharpe Ratio (1Y)-1.27-0.21
Sortino Ratio (1Y)-1.45-0.28

Profitability

ROE (TTM)

Both companies show strong equity returns, but Alnylam Pharmaceuticals (ALNY) at 138.07% is the standout with ROE above its industry range; Novo Nordisk (NVO) at 58.38% also sits in the top quartile.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

138.07%

ALNY
138.07%
Max
109.18%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

58.38%

Max
109.18%
NVO
58.38%
Q3
6.23%
Median
-26.66%
Q1
-64.05%
Min
-167.77%
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their ROE against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Net Margin (TTM)

Both Alnylam Pharmaceuticals (ALNY) at 52.85% and Novo Nordisk (NVO) at 33.92% keep an unusually large share of revenue as bottom-line profit — each net margin clears its industry’s benchmark range.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

52.85%

ALNY
52.85%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

33.92%

NVO
33.92%
Max
18.05%
Q3
4.78%
Median
0.00%
Q1
-4.14%
Min
-17.05%
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their net margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Operating Margin (TTM)

Both Alnylam Pharmaceuticals (ALNY) at 23.72% and Novo Nordisk (NVO) at 40.05% convert sales into operating profit at a top-quartile rate, pointing to tighter cost discipline before financing and tax.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

23.72%

Max
83.12%
ALNY
23.72%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

40.05%

Max
83.12%
NVO
40.05%
Q3
14.77%
Median
0.00%
Q1
-78.82%
Min
-207.40%
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their operating margin against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Profitability Metrics

Profitability metrics for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO)
MetricALNYNVO
ROE (TTM)138.07%58.38%
ROA (TTM)9.51%19.05%
Net Margin (TTM)52.85%33.92%
Operating Margin (TTM)23.72%40.05%
Gross Margin (TTM)77.28%83.33%

Growth

Revenue Growth

Alnylam Pharmaceuticals (ALNY) at 65.19% sits in the top revenue growth quartile, while Novo Nordisk (NVO) at 6.43% is closer to the peer norm — faster top-line expansion for ALNY.

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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their Revenue Growth across different time periods.

EPS Growth

Only one side can be read here: Novo Nordisk (NVO) reports EPS growth of 1.77%, ranked against its industry; Alnylam Pharmaceuticals (ALNY) has no EPS growth figure this period.

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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their EPS Growth across different time periods.

Growth Metrics

Growth metrics for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO)
MetricALNYNVO
Revenue Growth (YoY)65.19%6.43%
Revenue Growth (3Y CAGR)52.98%20.43%
EPS Growth (YoY)--1.77%
EPS Growth (3Y CAGR)--23.52%

Financial Strength

Current Ratio (MRQ)

Alnylam Pharmaceuticals (ALNY) at 2.48 keeps current ratio within its industry’s typical mid-range, while Novo Nordisk (NVO) at 0.85 runs in the tighter-liquidity quartile — a thinner cushion against current liabilities for NVO.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

2.48

Max
25.13
Q3
12.13
Median
5.52
ALNY
2.48
Q1
2.47
Min
0.10

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.85

Max
25.13
Q3
12.13
Median
5.52
Q1
2.47
NVO
0.85
Min
0.10
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their current ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Debt / Equity (MRQ)

Novo Nordisk (NVO) at 0.62 carries an industry-typical debt-to-equity mix, while Alnylam Pharmaceuticals (ALNY) at 0.83 uses more debt funding than most peers.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.83

Max
1.42
ALNY
0.83
Q3
0.65
Median
0.15
Q1
0.02
Min
0.00

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.62

Max
1.42
Q3
0.65
NVO
0.62
Median
0.15
Q1
0.02
Min
0.00
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their debt-to-equity ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Financial Strength Metrics

Financial strength metrics for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO)
MetricALNYNVO
Current Ratio (MRQ)2.480.85
Debt / Equity (MRQ)0.830.62
Net Debt / EBITDA-0.570.49

Dividends

Dividend Yield (TTM)

Alnylam Pharmaceuticals (ALNY) pays no dividend (yield 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Novo Nordisk (NVO) reports a yield of 29.03%, ranking against industry peers normally.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ALNY
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

29.03%

NVO
29.03%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their dividend yield against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Payout Ratio (TTM)

Alnylam Pharmaceuticals (ALNY) pays no dividend (payout 0.00%) — it may be reinvesting, using buybacks, or simply not returning cash through dividends. Meanwhile Novo Nordisk (NVO) reports a payout of 45.36%, ranking against industry peers normally.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.00%

ALNY
0.00%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

45.36%

NVO
45.36%
Max
0.00%
Q3
0.00%
Median
0.00%
Q1
0.00%
Min
0.00%
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their payout ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Dividend Metrics

Dividend metrics for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO)
MetricALNYNVO
Dividend Yield (TTM)0.00%29.03%
Dividend Payout Ratio (TTM)0.00%45.36%

Valuation

P/E Ratio (TTM)

Both Alnylam Pharmaceuticals (ALNY) at 7.88 and Novo Nordisk (NVO) at 10.18 sit in the cheaper earnings-multiple quartile for P/E ratio, with the market paying less for a dollar of trailing earnings than it pays for typical peers.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

7.88

Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
ALNY
7.88
Min
0.07

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

10.18

Max
85.34
Q3
43.46
Median
26.69
Q1
13.30
NVO
10.18
Min
0.07
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their P/E ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/S Ratio (TTM)

Novo Nordisk (NVO) at 0.53 sits in the cheaper P/S ratio quartile while Alnylam Pharmaceuticals (ALNY) at 4.17 prices around its industry’s middle — NVO costs less per dollar of sales, though read it alongside growth and margins.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

4.17

Max
58.18
Q3
25.77
Median
7.30
ALNY
4.17
Q1
3.01
Min
0.01

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

0.53

Max
58.18
Q3
25.77
Median
7.30
Q1
3.01
NVO
0.53
Min
0.01
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their P/S ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

P/B Ratio (MRQ)

On P/B ratio, both Alnylam Pharmaceuticals (ALNY) at 5.79 and Novo Nordisk (NVO) at 5.43 are valued close to their industries’ norm against book — neither stands out from peers.

ALNY

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.79

Max
13.53
Q3
6.54
ALNY
5.79
Median
3.25
Q1
1.69
Min
-5.59

NVO

Pharmaceuticals, Biotechnology & Life Sciences industry group

5.43

Max
13.53
Q3
6.54
NVO
5.43
Median
3.25
Q1
1.69
Min
-5.59
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Alnylam Pharmaceuticals (ALNY) vs. Novo Nordisk (NVO): A comparison of their P/B ratio against the Pharmaceuticals, Biotechnology & Life Sciences industry group benchmark.

Valuation Metrics

Valuation metrics for Alnylam Pharmaceuticals (ALNY) and Novo Nordisk (NVO)
MetricALNYNVO
P/E Ratio (TTM)7.8810.18
P/S Ratio (TTM)4.170.53
P/B Ratio (MRQ)5.795.43
Free Cash Flow Yield (TTM)1.57%18.43%